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susceptibility and environmental factors [ 1 , 2 ]. Thyroid peroxidase antibody (TPOAb) concentrations are elevated in more than 90% patients with Hashimoto thyroiditis [ 3 , 4 ]. Furthermore, TPOAb is mostly related to heritability [ 5 ]. It was estimated that
Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
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Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
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Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
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Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
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( 10 , 11 ). It is commonly acknowledged that free thyroxine (FT4), thyroid-stimulating hormone (TSH) and thyroid peroxidase antibody (TPOAb) serve as the primary indicators of thyroid function. Moreover, maternal thyroid dysfunction has been
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-39). All women were healthy, had no history of thyroid disease, were using the recommended iodine prophylaxis, and had normal thyroid-peroxidase antibodies (anti-TPO <50 IU/mL). Anti-TPO was only measured as it is considered as a more sensitive marker of
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/93. Native Tg and recombinant human TPO were used in all assay systems for the detection of TgAb and TPOAb, respectively. Table 1. Prevalence of thyroglobulin antibodies (TgAb) and thyroid peroxidase antibodies (TPOAb) in patients with subacute
Department of Internal Medicine, Chung-Ang University Hospital, Seoul, Korea
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Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
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Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Integrated Major in Innovative Medical Science, Seoul National University College of Medicine, Seoul, Korea
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Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea
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Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
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impact on anti-thyroid peroxidase antibody (anti-TPO Ab) and thyroid-stimulating hormone (TSH) levels in pregnant women ( 10 ). Additionally, the relationship between selenium deficiency and poor pregnancy outcomes also remains controversial. Several
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miscarriage at 11 weeks’ gestation. She feels well in herself. Her serum TSH is 4.5 mU/l, with normal circulating free thyroxine concentration. Serum thyroid peroxidase antibodies were negative. The results of the participants’ opinion are shown in figure 3
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.5–6.4 pmol/l), free T 4 12.87 (11.33–22.14 pmol/l), TSH 3.82 (0.63–4.82 mlU/l). Levels of thyroid antibodies consisting of thyroid peroxidase antibody (anti-TPO) were 600 (5–34 kU/l), and levels of the thyroglobulin antibodies (anti-TG) were 180.1 (0–60 kU
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levels of anti-thyroid peroxidase antibodies; (b) change from baseline in LT 4 replacement dosage, and (c) economic costs. Data Extraction and Synthesis Three review authors (E.J.v.Z., A.Y.A. and Z.F.) extracted study details and data using a
Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China
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, including the accessibility of eligible participants during the study period and the feasibility of collecting data. Patients with elevated serum thyroid autoantibodies (thyroid peroxidase antibodies (TPOAb) >200 IU/mL and/or anti-thyroglobulin antibodies
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Departments of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden
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Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands
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controls, while levothyroxine treatment was only present in controls. Laboratory Measurements Levels of fT 4 , thyroid-stimulating hormone (TSH) and thyroid peroxidase antibodies (anti-TPO) were measured in the available citrated plasma samples (103