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Multidisciplinary Thyroid Eye Consultation, Department of Endocrinology, Larrey University Hospital, Toulouse, France
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. What Does This Case Report Add? We report severe inflammatory ophthalmopathy in a patient with a non-small-cell lung cancer treated with anti-PD-1 monoclonal antibody (nivolumab). The euthyroid patient had no detectable anti
Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, South Korea
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Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju, South Korea
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Biomedical Research Institute, Gyeongsang National University Hospital, Jinju, South Korea
Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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are a family of nicotinamide adenine dinucleotide (NAD + )-dependent deacetylases that are involved in numerous cellular processes, such as energy metabolism, chromosomal stability, DNA repair, cell cycle progression, and apoptosis ( 10 ). Seven
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Gustave Roussy, Villejuif, France
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UMR 9019 CNRS F-94805 Villejuif, France
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Gustave Roussy, Villejuif, France
Sorbonne Université, Paris, France
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Technologies, P0447). We then washed the membranes three more times with TBS-T and visualized the proteins using enhanced chemiluminescence. Cell cycle Cells were seeded in six-well plates at an optimal density and then irradiated. Four days post
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stability, DNA repair, cell cycle checkpoints, and suppression of cell growth [ 10 ]. Similarly, p53 protein is known to maintain genome stability in response to diverse stress signals by coordinating specific cellular responses that include cellular
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that differentiated C cells might be less responsive to oncogenic activation than C cell precursors. Notably, cell proliferation is abundant in the developing ultimobranchial bodies, but all cells cease to multiply and exit cell cycle as evidenced by
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Instituto Nacional de Cancer (INCA), Rio de Janeiro, Brazil
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.Then we investigated the cell cycle phase distribution of the miR-130b-3p-transfected cells. As shown in figure 5 b, the S and G2-M phases population increased in PC Cl 3 cells expressing miR-130b-3p with respect to the control scrambled oligonucleotide
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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Service of Hematology and Laboratory of Hematology, Institut Central des Hôpitaux, Hôpital du Valais, Av. du Grand-Champsec, Sion, Switzerland
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University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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Established facts Diagnosis of Langerhans cell histiocytosis (LCH) in patients presenting with a single suprasellar lesion is challenging and requires transcranial biopsy, which is associated with increased morbidity. Only a few case
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through immunogenic cell death. RT- and ICI-related toxicities were mostly mild (G1), and none of the patients discontinued treatment due to TRAEs. One patient experienced severe (G3) laryngeal oedema shortly after one cycle of pembrolizumab, which may be
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the immune response by acting as a negative co-stimulator. It engages non-MHC cell surface receptors on antigen-presenting cells (known as B7s) to give an inhibitory signal to T-lymphocyte activation [ 1 ]. It acts as an important immune checkpoint to
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an overnight fast for blood sample collection on days 2–5 of the next menstrual cycle. If the patient had irregular periods and the last menstrual period had occurred > 35 days prior to the date of examination, then, after confirming they were not