Search for other papers by Caiyan Mo in
Google Scholar
PubMed
Search for other papers by Han Chen in
Google Scholar
PubMed
Search for other papers by Qi Zhang in
Google Scholar
PubMed
Search for other papers by Ying Guo in
Google Scholar
PubMed
Search for other papers by Liyong Zhong in
Google Scholar
PubMed
binding of thyroid-stimulating hormone receptor antibodies (TRAb) to thyroid-stimulating hormone (TSH) receptors leads to unregulated thyroid hormone production independent of pituitary TSH, resulting in hyperthyroidism ( 1 ). Central hyperthyroidism is a
Search for other papers by Diana Grove-Laugesen in
Google Scholar
PubMed
Search for other papers by Sofie Malmstroem in
Google Scholar
PubMed
Search for other papers by Eva Ebbehoj in
Google Scholar
PubMed
Search for other papers by Anne Lene Riis in
Google Scholar
PubMed
Search for other papers by Torquil Watt in
Google Scholar
PubMed
Search for other papers by Lars Rejnmark in
Google Scholar
PubMed
Search for other papers by Klavs Würgler Hansen in
Google Scholar
PubMed
stiffness in terms of lower night-time PWV dipping and lower night-time central PP dipping. The existing literature on arterial stiffness in hyperthyroid patients with GD is sparse and shows conflicting results. This may be due to the use of different
Search for other papers by Irene Campi in
Google Scholar
PubMed
Search for other papers by Maura Agostini in
Google Scholar
PubMed
Search for other papers by Federica Marelli in
Google Scholar
PubMed
Search for other papers by Tiziana de Filippis in
Google Scholar
PubMed
Search for other papers by Beatriz Romartinez-Alonso in
Google Scholar
PubMed
Search for other papers by Odelia Rajanayagam in
Google Scholar
PubMed
Search for other papers by Giuditta Rurale in
Google Scholar
PubMed
Search for other papers by Ilaria Gentile in
Google Scholar
PubMed
Search for other papers by Federica Spagnolo in
Google Scholar
PubMed
Search for other papers by Massimiliano Andreasi in
Google Scholar
PubMed
Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
Search for other papers by Francesco Ferraù in
Google Scholar
PubMed
Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
Search for other papers by Salvatore Cannavò in
Google Scholar
PubMed
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
Search for other papers by Laura Fugazzola in
Google Scholar
PubMed
Search for other papers by Krishna V. Chatterjee in
Google Scholar
PubMed
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
Search for other papers by Luca Persani in
Google Scholar
PubMed
residues 234–264, 316–347, and 426–454 of thyroid hormone receptor beta. Spurious hyperthyroxinemia due to thyroid function assay interferences is a frequent pitfall in the differential diagnosis of central hyperthyroidism. Novel Insights
Search for other papers by Nelli Suonsyrjä in
Google Scholar
PubMed
Search for other papers by Saara Metso in
Google Scholar
PubMed
Search for other papers by Eeva Moilanen in
Google Scholar
PubMed
Search for other papers by Jukka Mustonen in
Google Scholar
PubMed
Search for other papers by Pia Jaatinen in
Google Scholar
PubMed
Search for other papers by Ilkka Pörsti in
Google Scholar
PubMed
Objective:
Hyperthyroidism increases cardiovascular morbidity and mortality, but the underlying mechanisms are not fully understood. In this study we compared non-invasive haemodynamics between 20 hyperthyroid patients and 60 euthyroid subjects.
Methods:
The measurements were performed median 6 days after the initiation of antithyroid medication when the patients were still hyperthyroid. Three controls matched for age, sex, body mass index, and smoking status were selected for each patient. Recordings were performed during rest and passive head-up tilt using whole-body impedance cardiography, radial pulse wave analysis, and finger blood pressure measurements.
Results:
Systolic and diastolic blood pressures in the aorta and radial artery were similar in hyperthyroid and euthyroid subjects, while finger blood pressure was 16/12 mmHg lower in hyperthyroidism (p<0.001). Pulse wave velocity and aortic pulse pressure were similar, but radial pulse pressure was ~5 mmHg higher in hyperthyroidism (p=0.040) due to augmented amplification (p=0.045). Systemic vascular resistance was reduced (-18%), whereas heart rate (+19 beats/min), cardiac index (+28%), and left cardiac work (+31%) were increased in hyperthyroidism (p<0.001). Subendocardial viability ratio, reflecting the balance between coronary perfusion and pressure load, was reduced by 19% in hyperthyroidism (p<0.001). Compared with euthyroid subjects, hyperthyroid patients presented with reductions in systolic and diastolic finger blood pressures (p<0.001), and higher increase in heart rate (p=0.014) during upright posture.
Conclusions:
Hyperthyroid patients exhibited hyperdynamic circulation, reduced vascular resistance, reduced peripheral but not central blood pressure, and higher pulse pressure amplification. Furthermore, left cardiac workload was increased in parallel with unfavourable changes in coronary perfusion conditions.
Search for other papers by Georgios Kostopoulos in
Google Scholar
PubMed
Search for other papers by Grigoris Effraimidis in
Google Scholar
PubMed
infarction, heart failure, and stroke are other common risk factors for AF ( 3 ). Today, the increased knowledge of the genetic causes of AF has revealed around 140 genetic loci associated with AF ( 4 ). Hyperthyroidism is also a common condition with an
Department of Clinical Medicine, Aalborg University, Aalborg, Aarhus, Denmark
Search for other papers by Stine Linding Andersen in
Google Scholar
PubMed
Search for other papers by Jørn Olsen in
Google Scholar
PubMed
Search for other papers by Chun Sen Wu in
Google Scholar
PubMed
Department of Clinical Medicine, Aalborg University, Aalborg, Aarhus, Denmark
Search for other papers by Peter Laurberg in
Google Scholar
PubMed
adverse outcome of pregnancy is less common than the early pregnancy loss but frequent enough to be of major concern [ 1 ]. Hyperthyroidism in women of reproductive age is most often caused by Graves' disease with autoimmunity against the thyroid
Search for other papers by Katarzyna Pelewicz in
Google Scholar
PubMed
Search for other papers by Rafał Wolny in
Google Scholar
PubMed
Search for other papers by Tomasz Bednarczuk in
Google Scholar
PubMed
Search for other papers by Piotr Miśkiewicz in
Google Scholar
PubMed
it can persist causing hypothyroidism. A pathologic response to the exogenous iodine load may lead to iodine-induced hyperthyroidism (IIH), known as the Jod-Basedow phenomenon. IIH is infrequent, but elderly patients and individuals with autonomously
Search for other papers by Kira Bang Bové in
Google Scholar
PubMed
Institute of Public Health, University of Copenhagen, Odense, Denmark
Search for other papers by Torquil Watt in
Google Scholar
PubMed
Search for other papers by Asmus Vogel in
Google Scholar
PubMed
Search for other papers by Laszlo Hegedüs in
Google Scholar
PubMed
National Research Centre for the Working Environment, Copenhagen, Odense, Denmark
Search for other papers by Jakob Bue Bjoerner in
Google Scholar
PubMed
Department of Palliative Medicine, Bispebjerg Hospital, Odense, Denmark
Search for other papers by Mogens Groenvold in
Google Scholar
PubMed
Search for other papers by Steen Joop Bonnema in
Google Scholar
PubMed
Search for other papers by Åse Krogh Rasmussen in
Google Scholar
PubMed
Search for other papers by Ulla Feldt-Rasmussen in
Google Scholar
PubMed
depression [ 2 , 3 , 4 , 5 , 6 ] but increased prevalence of anxiety and depression is also found in hyperthyroidism [ 7 ], particularly in the early phase of Graves' disease [ 8 , 9 , 10 , 11 ], compared with the general population or compared with patients
Search for other papers by P. Beck-Peccoz in
Google Scholar
PubMed
Search for other papers by A. Lania in
Google Scholar
PubMed
Search for other papers by A. Beckers in
Google Scholar
PubMed
Search for other papers by K. Chatterjee in
Google Scholar
PubMed
Search for other papers by J.-L. Wemeau in
Google Scholar
PubMed
Introduction The syndrome of ‘inappropriate secretion of TSH' was the term coined originally [ 1 ] to indicate two forms of central hyperthyroidism, i.e. thyrotropin (TSH)-secreting pituitary adenomas (TSHomas) and resistance to thyroid
Search for other papers by Peter Laurberg in
Google Scholar
PubMed
manifestations in each organ. It thus follows that patients with GO suffer from Graves' disease whether they are hyper-, hypo- or euthyroid. However, many authors narrow Graves' disease down to include patients with hyperthyroidism only and state that GO (or
