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results of the participants’ opinion are shown in figure 1 . Fig. 1 Case scenario 1, 53-year-old female, TSH 6.8 mU/l. Case 1b: As in case 1a, but she was also now noted to have dyslipidaemia, with a serum LDL cholesterol of 6
Royal Victoria Infirmary, Newcastle upon Tyne, UK
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Queen Elizabeth Hospital, Gateshead, UK
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through March 2013. For our Medline search, we entered in various combinations the terms thyrotropin (TSH), L -thyroxine, SCH, goitre, replacement therapy, CV risk, heart, dyslipidaemia, diabetes, obesity, mental health, quality of life, drugs. The
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developed severe hypothyroidism (TSH 201 mIU/ml and fT 4 of 2.3 pmol/L) with symptoms of fatigue, increasing weight, constipation, hoarse voice and cold intolerance. She also had abnormal liver function tests and dyslipidaemia. In her personal medical
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Department of Endocrinology, The Christie Manchester Academic Health Science Centre, Manchester, UK
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patients. This fits to previous studies were increased triglycerides were found in approximately 1/3 of all patients with overt hypothyroidism, mainly as part of dyslipidaemia type IIb but also of type IV. These relations are less clear in subclinical