Genfeng Yu
Genfeng Yu
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Siyang Liu
Siyang Liu
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Cheng Song
Cheng Song
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Qintao Ma
Qintao Ma
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Xingying Chen
Xingying Chen
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Yuqi Jiang
Yuqi Jiang
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Hualin Duan
Hualin Duan
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Yajun He
Yajun He
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Dongmei Wang
Dongmei Wang
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Heng Wan
Heng Wan
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Jie Shen
Jie Shen
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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central sensitivity indices include the thyrotroph thyroxine resistance index (TT4RI) and TSH index (TSHI). The FT3/FT4 ratio reflects deiodinase activity and is a proxy for peripheral thyroid hormone sensitivity ( 21 ). Central resistance phenomena affect
Jan Debeij
Jan Debeij
Departments of Clinical Epidemiology, Leiden University Medical Centre, Leiden
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Suzanne C. Cannegieter
Suzanne C. Cannegieter
Departments of Clinical Epidemiology, Leiden University Medical Centre, Leiden
Departments of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden
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Departments of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden
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Bregje van Zaane
Bregje van Zaane
Departments of Internal Medicine, Slotervaart Hospital
Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands
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Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands
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Anton P. van Zanten
Anton P. van Zanten
Departments of Clinical Biochemistry, Slotervaart Hospital
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Frits R. Rosendaal
Frits R. Rosendaal
Departments of Clinical Epidemiology, Leiden University Medical Centre, Leiden
Departments of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden
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Departments of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden
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Victor E.A. Gerdes
Victor E.A. Gerdes
Departments of Internal Medicine, Slotervaart Hospital
Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands
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Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands
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Pieter H. Reitsma
Pieter H. Reitsma
Departments of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden
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Olaf M. Dekkers
Olaf M. Dekkers
Departments of Clinical Epidemiology, Leiden University Medical Centre, Leiden
Departments of Endocrinology and Metabolism, Leiden University Medical Centre, Leiden
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Departments of Endocrinology and Metabolism, Leiden University Medical Centre, Leiden
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, such as comorbidities, older age and use of comedication [ 1 , 2 ]. Recently the relation between thyroid hormone and the coagulation system has gained interest as a focus of research [ 3 , 4 , 5 , 6 , 7 ]. High levels of free thyroxine (fT 4 ) are
Laura P.B. Elbers
Laura P.B. Elbers
Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam
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Departments of Vascular Medicine, University of Amsterdam, Amsterdam
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Hjalmar A. Boon
Hjalmar A. Boon
Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
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Maaike I. Moes
Maaike I. Moes
Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
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Bregje van Zaane
Bregje van Zaane
Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam
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Departments of Vascular Medicine, University of Amsterdam, Amsterdam
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Dees P.M. Brandjes
Dees P.M. Brandjes
Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam
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Departments of Vascular Medicine, University of Amsterdam, Amsterdam
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Eric Fliers
Eric Fliers
Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam
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Harry R. Büller
Harry R. Büller
Departments of Vascular Medicine, University of Amsterdam, Amsterdam
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Suzanne Cannegieter
Suzanne Cannegieter
Department of Clinical Epidemiology, Leiden University Medical Center
Einthoven Laboratory for Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Victor E.A. Gerdes
Victor E.A. Gerdes
Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam
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Departments of Vascular Medicine, University of Amsterdam, Amsterdam
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thromboembolism (VTE) or bleeding. Higher plasma levels of free thyroxine (FT 4 ) have been associated with an increased VTE risk [ 1 , 2 , 3 ]. Conversely, lower levels of FT 4 seem to be associated with a bleeding tendency [ 4 , 5 ]. An observational cohort
Salman Razvi
Salman Razvi
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK
Department of Endocrinology, Gateshead Health NHS Foundation Trust, Gateshead, UK
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Department of Endocrinology, Gateshead Health NHS Foundation Trust, Gateshead, UK
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Avais Jabbar
Avais Jabbar
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK
Department of Cardiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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Department of Cardiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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Arjola Bano
Arjola Bano
Department of Cardiology, Institute of Social and Preventive Medicine, University of Bern, Bern University Hospital, Bern, Switzerland
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Lorna Ingoe
Lorna Ingoe
Department of Endocrinology, Gateshead Health NHS Foundation Trust, Gateshead, UK
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Peter Carey
Peter Carey
Departments of Endocrinology and Cardiology, South Tyneside and Sunderland NHS Foundation Trust, Sunderland, UK
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Shahid Junejo
Shahid Junejo
Departments of Endocrinology and Cardiology, South Tyneside and Sunderland NHS Foundation Trust, Sunderland, UK
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Honey Thomas
Honey Thomas
Department of Cardiology, Northumbria Healthcare NHS Foundation Trust, Cramlington, UK
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Caroline Addison
Caroline Addison
Department of Biochemistry, Gateshead Health NHS Foundation Trust, Gateshead, UK
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David Austin
David Austin
Department of Cardiology, South Tees Health NHS Foundation Trust, Middlesbrough, UK
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John P Greenwood
John P Greenwood
Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK
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Azfar G Zaman
Azfar G Zaman
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK
Department of Cardiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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Department of Cardiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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in groups B (low FT3 and low CRP), C (medium FT3 and low, medium and high CRP) and D (high FT3 and high CRP) had an increased risk of subsequent mortality (hazard ratios between 1.42 and 1.52) compared to group E. Figure 4 T3 and CRP levels and
Rudolf Hoermann
Rudolf Hoermann
Department of Nuclear Medicine, Klinikum Luedenscheid, Luedenscheid, Germany
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John E.M. Midgley
John E.M. Midgley
North Lakes Clinical, Ilkley, UK
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Rolf Larisch
Rolf Larisch
Department of Nuclear Medicine, Klinikum Luedenscheid, Luedenscheid, Germany
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Johannes W. Dietrich
Johannes W. Dietrich
Medical Department I, Endocrinology and Diabetology, Bergmannsheil University Hospitals, Ruhr University of Bochum
Ruhr Center for Rare Diseases (CeSER), Ruhr University of Bochum and Witten/Herdecke University, Bochum, Germany
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Ruhr Center for Rare Diseases (CeSER), Ruhr University of Bochum and Witten/Herdecke University, Bochum, Germany
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ELISA (Anti-TSH-Receptor; EUROIMMUN AG, Luebeck, Germany). Interrelational Measures As a simple estimate of the conversion of T 4 to T 3 , we used the FT 3 -FT 4 ratio of the molar serum concentrations of the hormones. We divided FT 4 by TSH
Giulia Brigante
Giulia Brigante
Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Azienda USL, Modena, Italy
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Azienda USL, Modena, Italy
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Giorgia Spaggiari
Giorgia Spaggiari
Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Azienda USL, Modena, Italy
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Azienda USL, Modena, Italy
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Daniele Santi
Daniele Santi
Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Azienda USL, Modena, Italy
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Azienda USL, Modena, Italy
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Katia Cioni
Katia Cioni
Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Azienda USL, Modena, Italy
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Azienda USL, Modena, Italy
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Valentina Gnarini
Valentina Gnarini
Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Azienda USL, Modena, Italy
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Azienda USL, Modena, Italy
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Chiara Diazzi
Chiara Diazzi
Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Azienda USL, Modena, Italy
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Azienda USL, Modena, Italy
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Elisa Pignatti
Elisa Pignatti
Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Center of Genomic Research, University of Modena and Reggio Emilia
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Center of Genomic Research, University of Modena and Reggio Emilia
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Livio Casarini
Livio Casarini
Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Center of Genomic Research, University of Modena and Reggio Emilia
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Center of Genomic Research, University of Modena and Reggio Emilia
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Marco Marino
Marco Marino
Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Center of Genomic Research, University of Modena and Reggio Emilia
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Center of Genomic Research, University of Modena and Reggio Emilia
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Frank Tüttelmann
Frank Tüttelmann
Institute of Human Genetics, University of Munster, Munster, Germany
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Cesare Carani
Cesare Carani
Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Azienda USL, Modena, Italy
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Azienda USL, Modena, Italy
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Manuela Simoni
Manuela Simoni
Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Center of Genomic Research, University of Modena and Reggio Emilia
Azienda USL, Modena, Italy
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Center of Genomic Research, University of Modena and Reggio Emilia
Azienda USL, Modena, Italy
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, there were no differences among the three groups (respectively p = 0.71; p = 0.34). No significant differences were found in serum levels of fT 3 (p = 0.59), fT 4 (p = 0.16), Ab anti-TG (p = 0.48), fT 3 /fT 4 ratio (p = 0.76) and fT 3 /TSH ratio (p
Françoise Brucker-Davis
Françoise Brucker-Davis
Department of Endocrinology, Diabetology and Reproductive Medicine
Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France
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Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France
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Patricia Panaïa-Ferrari
Patricia Panaïa-Ferrari
Departments of Biochemistry, UMR U895, Université Nice-Sophia Antipolis, Nice, France
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Jocelyn Gal
Jocelyn Gal
Departments of Biostatistics, CHU de Nice, UMR U895, Université Nice-Sophia Antipolis, Nice, France
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Patrick Fénichel
Patrick Fénichel
Department of Endocrinology, Diabetology and Reproductive Medicine
Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France
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Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France
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Sylvie Hiéronimus
Sylvie Hiéronimus
Department of Endocrinology, Diabetology and Reproductive Medicine
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5th or 10th percentile of the reference range for FT4 associated with normal TSH [ 3 , 4 ]. There is, however, the question of threshold for normal values, linked in part to the lack of laboratory reference ranges in pregnancy. The association of
Veeravich Jaruvongvanich
Veeravich Jaruvongvanich
Department of Internal Medicine, University of Hawaii, Honolulu, HI, USA
Department of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
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Department of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
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Anawin Sanguankeo
Anawin Sanguankeo
Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA
Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
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Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
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Sikarin Upala
Sikarin Upala
Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA
Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
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Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
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F, Mamac RY, Yenigun M: FT 3 /FT 4 ratio predicts non-alcoholic fatty liver disease independent of metabolic parameters in patients with euthyroidism and hypothyroidism. Clinics (Sao Paulo) 2016;71:221-225. 10.6061/clinics/2016(04)08 27166773
Érique José F. Peixoto de Miranda
Érique José F. Peixoto de Miranda
Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil
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Márcio Sommer Bittencourt
Márcio Sommer Bittencourt
Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil
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Itamar S. Santos
Itamar S. Santos
Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil
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Paulo A. Lotufo
Paulo A. Lotufo
Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil
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Isabela M. Benseñor
Isabela M. Benseñor
Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil
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overnight fast. fT 4 levels were only evaluated in participants who presented altered TSH levels. In this study, reference range levels were 0.4-4.0 μIU/ml for TSH and 10.3-24.45 pmol/l for fT 4 , i.e. similar to those used in the National Health and
Tanja Diana
Tanja Diana
Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany
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Hans-Peter Holthoff
Hans-Peter Holthoff
AdvanceCor GmbH, Martinsried, Germany
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Julia Fassbender
Julia Fassbender
AdvanceCor GmbH, Martinsried, Germany
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Christian Wüster
Christian Wüster
Endocrine Laboratory and Practice Prof. Wüster, Mainz, Germany
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Michael Kanitz
Michael Kanitz
Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany
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George J. Kahaly
George J. Kahaly
Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany
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Martin Ungerer
Martin Ungerer
AdvanceCor GmbH, Martinsried, Germany
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week 27 (1.4 ng/mL [1.1; 1.7]), respectively. In contrast, in Ad-TSHR-immunized mice, fT4 concentrations were markedly higher at weeks 17 (4.4 ng/mL [3.9; 6]) and 27 (4.5 ng/mL [4.2; 6]) than in Ad-GFP-immunized mice (2 ng/mL [1.8; 2.1] and 1.4 ng/mL [1
