Department of Pathology, General University Hospital of Ciudad Real, Ciudad Real, Spain
Search for other papers by Ana Isabel Álvarez-Mancha in
Google Scholar
PubMed
Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Málaga, Spain
Search for other papers by Isabel Mancha-Doblas in
Google Scholar
PubMed
The Biomedical Research Institute of Malaga and Platform in Nanomedicine (IBIMA-BIONAND Platform), University of Malaga, Malaga, Spain
Search for other papers by María Molina-Vega in
Google Scholar
PubMed
Search for other papers by Diego Fernández-García in
Google Scholar
PubMed
The Biomedical Research Institute of Malaga and Platform in Nanomedicine (IBIMA-BIONAND Platform), University of Malaga, Malaga, Spain
Search for other papers by Ana María Gómez-Pérez in
Google Scholar
PubMed
Department of Pathology, Virgen de la Victoria University Hospital, Málaga, Spain
Search for other papers by Elena Gallego-Domínguez in
Google Scholar
PubMed
Department of Pathology, Virgen de la Victoria University Hospital, Málaga, Spain
Search for other papers by María Victoria Ortega-Jiménez in
Google Scholar
PubMed
Search for other papers by Isabel Hierro-Martín in
Google Scholar
PubMed
Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Málaga, Spain
The Biomedical Research Institute of Malaga and Platform in Nanomedicine (IBIMA-BIONAND Platform), University of Malaga, Malaga, Spain
Search for other papers by Francisco J Tinahones in
Google Scholar
PubMed
Introduction Clinical management of the thyroid nodules is based on a combination of clinical risk factors, functional status, ultrasound patterns, and cytologic findings when fine needle aspiration (FNA) is indicated ( 1 , 2 , 3 , 4 , 5
Search for other papers by Andrea Leoncini in
Google Scholar
PubMed
Search for other papers by Chiara Camponovo in
Google Scholar
PubMed
Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland
Search for other papers by Gaetano Paone in
Google Scholar
PubMed
Search for other papers by Elena Gamarra in
Google Scholar
PubMed
Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland
Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
Search for other papers by Giorgio Treglia in
Google Scholar
PubMed
Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland
Search for other papers by Pierpaolo Trimboli in
Google Scholar
PubMed
://doi.org/10.1111/cen.14204 ) 12 Noto B Eveslage M Pixberg M Gonzalez Carvalho JM Schäfers M Riemann B & Kies P . Prevalence of hyperfunctioning thyroid nodules among those in need of fine needle aspiration cytology according to ATA 2015, EU
Search for other papers by Tayyab S. Khan in
Google Scholar
PubMed
Search for other papers by Esha Sharma in
Google Scholar
PubMed
Search for other papers by Baldev Singh in
Google Scholar
PubMed
Search for other papers by Bikram Jammu in
Google Scholar
PubMed
Search for other papers by Amarinder Chadha in
Google Scholar
PubMed
Search for other papers by Divya Markanday in
Google Scholar
PubMed
Search for other papers by Yan Yan Wu in
Google Scholar
PubMed
Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
Search for other papers by Harpreet S. Bajaj in
Google Scholar
PubMed
Introduction Ultrasound-guided thyroid fine needle aspiration and biopsy (FNAB) has become the test of choice for evaluation of thyroid nodules. It combines ease of access and a high sensitivity and specificity to offer reliable results to aid
Search for other papers by Roberto Negro in
Google Scholar
PubMed
Search for other papers by Roberto Attanasio in
Google Scholar
PubMed
Search for other papers by Franco Grimaldi in
Google Scholar
PubMed
Search for other papers by Andrea Frasoldati in
Google Scholar
PubMed
Search for other papers by Rinaldo Guglielmi in
Google Scholar
PubMed
Search for other papers by Enrico Papini in
Google Scholar
PubMed
techniques reveals an epidemic of nonpalpable thyroid nodules that necessitate a complete workup, including US, testing for thyroid-stimulating hormone, and fine-needle aspiration (FNA) [ 3 ]. The first objective in thyroid nodule evaluation is to exclude
Search for other papers by Taha Yusuf Kuzan in
Google Scholar
PubMed
Search for other papers by Ceren Canbey Goret in
Google Scholar
PubMed
thyroid nodules are benign, and 5–15% of them are thyroid malignancies. Fine-needle aspiration biopsy (FNAB) is a reliable, minimally invasive diagnostic method with high sensitivity and specificity in the evaluation of thyroid nodules [ 2 , 4 - 7
Search for other papers by Chitra Choudhary in
Google Scholar
PubMed
Search for other papers by Leonard Wartofsky in
Google Scholar
PubMed
Search for other papers by Eshetu Tefera in
Google Scholar
PubMed
Search for other papers by Kenneth D. Burman in
Google Scholar
PubMed
can represent benign conditions such as neuromas, postoperative scar, suture granuloma, reactive lymphoid hyperplasia, benign thyroid tissue remnant or, instead, a malignant recurrence of thyroid cancer in which case fine-needle aspiration will show
Search for other papers by Catherine Brophy in
Google Scholar
PubMed
Search for other papers by Rania Mehanna in
Google Scholar
PubMed
Search for other papers by Julie McCarthy in
Google Scholar
PubMed
Search for other papers by Antoinette Tuthill in
Google Scholar
PubMed
Search for other papers by Matthew S. Murphy in
Google Scholar
PubMed
Search for other papers by Patrick Sheahan in
Google Scholar
PubMed
clinically apparent thyroid nodules is between 5 and 15% [ 2 ]. Fine-needle aspiration (FNA) cytology has demonstrated high utility in the diagnosis of thyroid nodules. In an effort to stratify thyroid nodules according to risk of malignancy in a consistent
Search for other papers by Mathieu Bergeron in
Google Scholar
PubMed
Search for other papers by Danielle Beaudoin in
Google Scholar
PubMed
What Is Known about This Topic So Far? • Although many authors recommend a core-needle biopsy as an alternative modality in cases of inconclusive cytology with fine-needle aspiration for thyroid nodule, it is not in the American Thyroid
Search for other papers by Catarina Silvestre in
Google Scholar
PubMed
Search for other papers by Joaquim Sampaio Matias in
Google Scholar
PubMed
Search for other papers by Helena Proença in
Google Scholar
PubMed
Search for other papers by Maria João Bugalho in
Google Scholar
PubMed
thyroid-stimulating hormone, colonoscopy, and mammography screening. In our series, the sensitivity of serum Ctn was higher than that of cytology by fine-needle aspiration, as reported by others [ 6 , 13 - 16 ]. As a matter of fact, on fine
Search for other papers by José I. López in
Google Scholar
PubMed
Search for other papers by Rosa Zabala in
Google Scholar
PubMed
Search for other papers by José Luís del Cura in
Google Scholar
PubMed
sensitivity and specificity of the technique [ 4 ], and makes it possible to take samples of the solid areas in cystic lesions. Despite fine-needle aspiration cytology (FNAC) being almost universally used to take thyroid samples and, accordingly, there being