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Enrico Papini Department of Endocrinology and Metabolism, Regina Apostolorum Hospital, Rome, Italy

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Hervé Monpeyssen Thyroid Unit, American Hospital, Paris, France

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Andrea Frasoldati Department of Endocrinology and Metabolism, Arcispedale Santa Maria Nuova IRCCS-ASL, Reggio Emilia, Italy

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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entire nodule or a large part of it [ 20 - 22 ]. The cost of MWA applicators is about EUR 600 in Europe. Treatment is performed on an outpatient basis and lasts 10–20 min (Table 2 ). High-Intensity Focused Ultrasound With HIFU, sparing of

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Giovanni Mauri Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy
Division of Interventional Radiology, European Institute of Oncology, IRCCS, Milan, Italy

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Laszlo Hegedüs Department of Endocrinology, Odense University Hospital, University of Southern Denmark, Odense, Denmark

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Steven Bandula Interventional Oncology Service, University College Hospital, London, United Kingdom

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Roberto Luigi Cazzato Department of Interventional Radiology, University Hospital of Strasbourg, Strasbourg, France

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Agnieszka Czarniecka The Oncologic and Reconstructive Surgery Clinic, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland

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Oliver Dudeck Center for Microtherapy, Klinik Hirslanden, Zurich, Switzerland

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Laura Fugazzola Department of Endocrinology and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Romana Netea-Maier Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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Gilles Russ Thyroid and Endocrine Tumors Unit, La Pitie-Salpetriere Hospital, Sorbonne University, Paris, France

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Göran Wallin Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden

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Enrico Papini Department of Endocrinology & Metabolism, Ospedale Regina Apostolorum, Albano, Italy

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the frequency of minor complications was 23% [ 34 ]. High-Intensity Focused Ultrasound Ablation High-intensity focused ultrasound ablation is the only completely noninvasive ablation technique. Ultrasonic energy, in the 20 kHz–200 Mhz range

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Andrea Frasoldati Division of Endocrinology, Arcispedale S. Maria Nuova, Reggio Emilia, Italy

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Roberto Negro Division of Endocrinology, “V. Fazzi” Hospital, Lecce, Italy

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Enrico Papini Division of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy

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0265-6736 12 Lang BH , Wong CK , Ma EP , Woo YC , Chiu KW . A propensity-matched analysis of clinical outcomes between open thyroid lobectomy and high-intensity focused ultrasound (HIFU) ablation of benign thyroid nodules

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Cosimo Durante Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

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Laszlo Hegedüs Department of Endocrinology, Odense University Hospital, Odense, Denmark

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Agnieszka Czarniecka M. Sklodowska-Curie National Research, Institute of Oncology Gliwice Branch, Gliwice, Poland

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Ralf Paschke Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Gilles Russ Thyroid and Endocrine Tumors Department, Pitié-Salpêtrière Hospital, Sorbonne University GRC N°16, Paris, France

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Fernando Schmitt Faculty of Medicine of University of Porto, CINTESIS@RISE and Institute of Molecular Pathology and Immunology, University of Porto (Ipatimup), Porto, Portugal

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Paula Soares Institute of Investigation and Innovation in Health (I3S), Faculty of Medicine of the University of Porto, Porto, Portugal

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Tamas Solymosi Endocrinology and Metabolism Clinic, Bugat Hospital, Gyöngyös, Hungary

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Enrico Papini Department of Endocrine and Metabolic Diseases, Regina Apostolorum Hospital, Albano, Rome, Italy

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, which use various energy sources: laser, radiofrequency, microwaves, or high-intensity focused ultrasound ( 17 ). MITs result in a relevant and long-lasting decrease of nodule volume (57–77% at 5 years) that is paralleled by improvement of local symptoms

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Rosa M. García-Moreno Endocrinology and Nutrition Department, Hospital Universitario La Paz, Madrid, Spain

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Cristina Escabias Nuclear Medicine Department, Hospital Universitario La Paz, Madrid, Spain

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Cristina Utrilla Radiology Department, Hospital Universitario La Paz, Madrid, Spain

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Elena Ruiz-Bravo Pathology Department, Hospital Universitario La Paz, Madrid, Spain

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Margarita Sánchez Ophthalmology Department, Hospital Universitario La Paz, Madrid, Spain

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Beatriz Lecumberri Endocrinology and Nutrition Department, Hospital Universitario La Paz, Madrid, Spain

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already present in the CT images of the two 18F-FDG PET/CT performed previously. Fig. 1. a WBI scintigraphy anterior view showing high focal uptake in the right facial region as well as physiological tracer distribution and a focus of uptake in

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Ziyu Wan Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China
Nursing Department, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China

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Ying Li Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Xiaoqian Dong Xiangya School of Nursing, Central South University, Changsha, Hunan, China

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Yue Kang Xiangya School of Nursing, Central South University, Changsha, Hunan, China

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Juan Luo Xiangya School of Nursing, Central South University, Changsha, Hunan, China

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Jiangang Wang Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Pingting Yang Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Yaqin Wang Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Yinglong Duan Nursing Department, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China

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Jianfei Xie Nursing Department, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China

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Andy S K Cheng Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong, China

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blood glucose (FBG), glycated hemoglobin (HbA1C), serum triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C). Ultrasound examination Subjects were placed in a supine position with the neck exposed, and thyroid ultrasonography was

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Chantal A Lebbink Wilhelmina Children’s Hospital and Princess Máxima Center, Utrecht, The Netherlands

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Thera P Links Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Agnieszka Czarniecka The Oncologic and Reconstructive Surgery Clinic, M. Sklodowska-Curie National Research Institute of Oncology Gliwice Branch, Gliwice, Poland

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Renuka P Dias Department of Paediatric Endocrinology and Diabetes, Birmingham Children's Hospital NHS Foundation Trust, Birmingham, United Kingdom

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Rossella Elisei Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Louise Izatt Department of Clinical Genetics, Guy's and St Thomas’ NHS Foundation Trust, London, United Kingdom

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Heiko Krude Institute of Experimental Pediatric Endocrinology, Charité - Universitätsmedizin, Berlin, Germany

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Kerstin Lorenz Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany

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Markus Luster Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany

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Kate Newbold Thyroid Therapy Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom

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Arnoldo Piccardo Department of Nuclear Medicine, EO Ospedali Galliera, Genoa, Italy

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Manuel Sobrinho-Simões University Hospital of São João, Medical Faculty and Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal

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Toru Takano Thyroid Center, Rinku General Medical Center, Osaka, Japan

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A S Paul van Trotsenburg Department of Pediatric Endocrinology, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands

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Frederik A Verburg Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

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Hanneke M van Santen Wilhelmina Children’s Hospital and Princess Máxima Center, Utrecht, The Netherlands

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children with DTC are stratified according to those who may benefit from higher-intensity treatment vs those for whom lower-intensity treatment will suffice. By stratification, the goals of therapy for pediatric DTC (to maintain the high survival rate with

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Hayri Bostan Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey

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Muhammed Erkam Sencar Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey

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Murat Calapkulu Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey

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Sema Hepsen Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey

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Hakan Duger Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey

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Ilknur Ozturk Unsal Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey

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Mustafa Ozbek Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey

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Erman Cakal Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey

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female-male ratio was approximately 3:1. The mean pain intensity score, which measures the severity of neck pain in the last 24 h, was high (7.74 ± 1.56). Neck pain radiating to the jaw/ear was seen in most patients (71.1%). The vast majority (93.4%) of

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Stan R Ursem Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands

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Anita Boelen Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands

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Eveline Bruinstroop Department of Endocrinology and Metabolism, Amsterdam UMC, Location University of Amsterdam, Amsterdam, The Netherlands

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Petra J M Elders Department of General Practice, Amsterdam UMC Location Vrije Universiteit, Amsterdam, The Netherlands
Amsterdam Public Health Research Institute, Amsterdam UMC, The Netherlands

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Jacobijn Gussekloo LUMC Center for Medicine for Older People, Leiden University Medical Center, Leiden, The Netherlands
Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands

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Rosalinde K E Poortvliet LUMC Center for Medicine for Older People, Leiden University Medical Center, Leiden, The Netherlands
Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands

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Annemieke C Heijboer Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location Vrije Universiteit Amsterdam, Boelelaan, Amsterdam, The Netherlands

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Wendy P J den Elzen Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Laboratory Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Public Health Research Institute, Meibergdreef, Amsterdam, The Netherlands

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diagnostic testing, threshold for starting therapy, and intensity of follow-up diagnostic between guidelines and between primary and secondary care, we scored these items as low, intermediate, or high. Concerning diagnostic testing, recommendations to perform

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Fahim U. Hassan Nuclear Medicine Department, Borough Wing, Guy's Hospital, London, UK

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Hosahalli K. Mohan Nuclear Medicine Department, Borough Wing, Guy's Hospital, London, UK

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differentiated thyroid cancer. Functional imaging using iodine-123 and iodine-131 ( 131 I), in particular, provides information regarding suitability for therapy and the comprehensive staging of disease. Ultrasound remains the first line of investigation for

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