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Dulani Kottahachchi
Dulani Kottahachchi
Department of Endocrinology and Diabetes, The Alfred Hospital, Australia
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Duncan J. Topliss
Duncan J. Topliss
Department of Endocrinology and Diabetes, The Alfred Hospital, Australia
Department of Medicine, Monash University, Melbourne, VIC, Australia
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Department of Medicine, Monash University, Melbourne, VIC, Australia
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Introduction Immunoglobulin G4-related disease (IgG4-RD) is a new clinical disease entity which is characterized by a dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells in the affected tissues, with a tendency to form
Christophe Ghys
Christophe Ghys
Department of Endocrinology, Universitair Ziekenhuis Brussel, Belgium
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Michel Depierreux
Michel Depierreux
Departments of Pathology, Brussels, Belgium
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Elçin Ozalp
Elçin Ozalp
Departments of Nuclear Medicine, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium
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Brigitte Velkeniers
Brigitte Velkeniers
Department of Endocrinology, Universitair Ziekenhuis Brussel, Belgium
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What Is Known about This Topic? • Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized fibroinflammatory process defined by a dense lymphoplasmacytic infiltrate rich in IgG4. Riedel's thyroiditis and a subclass of sclerosing
Asena Gökçay Canpolat
Asena Gökçay Canpolat
Department of Endocrinology and Metabolism, School of Medicine, Ankara University, Ankara, Turkey
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Murat Cinel
Murat Cinel
Department of Endocrinology and Metabolism, School of Medicine, Ankara University, Ankara, Turkey
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Serpil Dizbay Sak
Serpil Dizbay Sak
Department of Pathology, School of Medicine, Ankara University, Ankara, Turkey
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Işılay Taşkaldıran
Işılay Taşkaldıran
Department of Endocrinology and Metabolism, Ankara Training and Research Hospital, Ankara, Turkey
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Hakan Korkmaz
Hakan Korkmaz
Department of Endocrinology and Metabolism, School of Medicine, Süleyman Demirel University, Isparta, Turkey
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Özgür Demir
Özgür Demir
Department of Endocrinology and Metabolism, School of Medicine, Ankara University, Ankara, Turkey
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Reyhan Ersoy
Reyhan Ersoy
Department of Endocrinology and Metabolism, School of Medicine, Yıldırım Beyazıt University, Ankara, Turkey
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Selçuk Dağdelen
Selçuk Dağdelen
Department of Endocrinology and Metabolism, School of Medicine, Hacettepe University, Ankara, Turkey
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Dilek Berker
Dilek Berker
Department of Endocrinology and Metabolism, Ankara City Hospital, University of Health Sciences, Ankara, Turkey
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Klara Dalva
Klara Dalva
Department of Haematology, School of Medicine, Ankara University, Ankara, Turkey
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Adile Begüm Bahçecioğlu Mutlu
Adile Begüm Bahçecioğlu Mutlu
Department of Endocrinology and Metabolism, School of Medicine, Ankara University, Ankara, Turkey
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Murat Faik Erdoğan
Murat Faik Erdoğan
Department of Endocrinology and Metabolism, School of Medicine, Ankara University, Ankara, Turkey
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Introduction Immunoglobulin G4-related disease (IgG4-RD) is characterized by an immune-mediated fibroinflammatory process that can affect various organs [ 1 ]. Riedel thyroiditis (RT) is a rare form of thyroiditis, which may also occur as part
Kenneth Ka Hei Lai
Kenneth Ka Hei Lai
Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong Special Administrative Region, China
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
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Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
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Fatema Mohamed Ali Abdulla Aljufairi
Fatema Mohamed Ali Abdulla Aljufairi
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Department of Ophthalmology, Salmaniya Medical Complex, Government Hospitals, Bahrain
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Department of Ophthalmology, Salmaniya Medical Complex, Government Hospitals, Bahrain
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Jake Uy Sebastian
Jake Uy Sebastian
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Department of Ophthalmology, Vicente Sotto Memorial Medical Center, Cebu City, Philippines
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Department of Ophthalmology, Vicente Sotto Memorial Medical Center, Cebu City, Philippines
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Yingying Wei
Yingying Wei
Department of Statistics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
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Ruofan Jia
Ruofan Jia
Department of Statistics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
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Karen Kar Wun Chan
Karen Kar Wun Chan
Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong Special Administrative Region, China
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Elaine Yuen Ling Au
Elaine Yuen Ling Au
Division of Clinical Immunology, Department of Pathology, Queen Mary Hospital, Hong Kong Special Administrative Region, China
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Alan Chun Hong Lee
Alan Chun Hong Lee
Division of Endocrinology and Metabolism, Department of Medicine, Queen Mary Hospital, Hong Kong Special Administrative Region, China
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Chiu Ming Ng
Chiu Ming Ng
Department of Medicine, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China
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Hunter Kwok Lai Yuen
Hunter Kwok Lai Yuen
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Hong Kong Eye Hospital, Hong Kong Special Administrative Region, China
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Hong Kong Eye Hospital, Hong Kong Special Administrative Region, China
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Wilson Wai Kuen Yip
Wilson Wai Kuen Yip
Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong Special Administrative Region, China
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Alvin Lerrmann Young
Alvin Lerrmann Young
Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong Special Administrative Region, China
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George Pak Man Cheng
George Pak Man Cheng
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
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Clement Chee Yung Tham
Clement Chee Yung Tham
Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong Special Administrative Region, China
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Hong Kong Eye Hospital, Hong Kong Special Administrative Region, China
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Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Hong Kong Eye Hospital, Hong Kong Special Administrative Region, China
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Chi Pui Pang
Chi Pui Pang
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
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Kelvin Kam Lung Chong
Kelvin Kam Lung Chong
Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong Special Administrative Region, China
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Hong Kong Eye Hospital, Hong Kong Special Administrative Region, China
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Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Hong Kong Eye Hospital, Hong Kong Special Administrative Region, China
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inhibitor immunoglobulin (TBII) assay is the conventional method, and it does not differentiate between the TRAbs subtypes ( 10 ). TBII level is closely related to Graves’ disease; however, the relationship with TED is inconsistent ( 11 , 12 , 13
Liyuan Liu
Liyuan Liu
Department of Endocrinology, Peking University First Hospital, Beijing, People’s Republic of China
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Yang Yu
Yang Yu
Department of Endocrinology, Peking University First Hospital, Beijing, People’s Republic of China
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Lei Chen
Lei Chen
Department of Ultrasound, Peking University First Hospital, Beijing, People’s Republic of China
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Yang Zhang
Yang Zhang
Department of Endocrinology, Peking University First Hospital, Beijing, People’s Republic of China
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Guizhi Lu
Guizhi Lu
Department of Endocrinology, Peking University First Hospital, Beijing, People’s Republic of China
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Ying Gao
Ying Gao
Department of Endocrinology, Peking University First Hospital, Beijing, People’s Republic of China
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Junqing Zhang
Junqing Zhang
Department of Endocrinology, Peking University First Hospital, Beijing, People’s Republic of China
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Yoshino T Kloppel G Heathcote JG Khosroshahi A Ferry JA Consensus statement on the pathology of IgG4-related disease . Modern Pathology 2012 25 1181 – 1192 . ( https://doi.org/10.1038/modpathol.2012.72 ) 17 Yu Y Gao Y . Progress in
Zohar Steinberg Ben-Zeev
Zohar Steinberg Ben-Zeev
Pediatric Department A, Ha’Emek Medical Center, Afula, Israel
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Marina Peniakov
Marina Peniakov
Neonatal Intensive Care Unit, Ha’Emek Medical Center, Afula, Israel
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Clari Felszer
Clari Felszer
Neonatal Intensive Care Unit, Ha’Emek Medical Center, Afula, Israel
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Scott A Weiner
Scott A Weiner
Neonatal Intensive Care Unit, Ha’Emek Medical Center, Afula, Israel
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Avishay Lahad
Avishay Lahad
Pediatric Department A, Ha’Emek Medical Center, Afula, Israel
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Shlomo Almashanu
Shlomo Almashanu
The National Newborn Screening Program, Ministry of Health, Tel Hashomer, Ramat Gan, Israel
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Yardena Tenenbaum Rakover
Yardena Tenenbaum Rakover
Consulting Medicine in Pediatric Endocrinology, Clalit Health Services, Afula, Israel
The Rappaport Faculty of Medicine, Technion, Institute of Technology, Haifa, Israel
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The Rappaport Faculty of Medicine, Technion, Institute of Technology, Haifa, Israel
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Introduction Maternal thyroid diseases are considered a risk factor for abnormal thyroid function at birth ( 1 , 2 , 3 , 4 , 5 ), as well as for long-term morbidity in offspring ( 1 , 6 , 7 , 8 , 9 , 10 , 11 ). Maternal
Earn H. Gan
Earn H. Gan
Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, United Kingdom
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Anna L. Mitchell
Anna L. Mitchell
Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, United Kingdom
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Ruth Plummer
Ruth Plummer
Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, United Kingdom
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Simon Pearce
Simon Pearce
Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, United Kingdom
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Petros Perros
Petros Perros
Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, United Kingdom
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in this disease [ 4 , 5 ]. However, immune-related adverse events, including endocrinopathies, are common with these therapies [ 6 , 7 ]. Hypophysitis is among the most common dose-dependent endocrine adverse event in anti-CTLA-4 therapies, followed
Yuan Li
Yuan Li
Department of Endocrinology, Peking University First Hospital, Beijing, China
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Chenxu Zhao
Chenxu Zhao
Department of Endocrinology, Peking University First Hospital, Beijing, China
Department of Endocrinology, The First Hospital of Hebei Medical University, Shijiazhuang, China
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Department of Endocrinology, The First Hospital of Hebei Medical University, Shijiazhuang, China
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Keli Zhao
Keli Zhao
Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
College of Life Science, University of the Chinese Academy of Sciences, Beijing, China
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College of Life Science, University of the Chinese Academy of Sciences, Beijing, China
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Nan Yu
Nan Yu
Department of Endocrinology, Peking University First Hospital, Beijing, China
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Yan Li
Yan Li
Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
College of Life Science, University of the Chinese Academy of Sciences, Beijing, China
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College of Life Science, University of the Chinese Academy of Sciences, Beijing, China
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Yang Yu
Yang Yu
Department of Endocrinology, Peking University First Hospital, Beijing, China
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Yang Zhang
Yang Zhang
Department of Endocrinology, Peking University First Hospital, Beijing, China
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Zhijing Song
Zhijing Song
Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
College of Life Science, University of the Chinese Academy of Sciences, Beijing, China
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College of Life Science, University of the Chinese Academy of Sciences, Beijing, China
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Youyuan Huang
Youyuan Huang
Department of Endocrinology, Peking University First Hospital, Beijing, China
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Guizhi Lu
Guizhi Lu
Department of Endocrinology, Peking University First Hospital, Beijing, China
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Ying Gao
Ying Gao
Department of Endocrinology, Peking University First Hospital, Beijing, China
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Junqing Zhang
Junqing Zhang
Department of Endocrinology, Peking University First Hospital, Beijing, China
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Xiaohui Guo
Xiaohui Guo
Department of Endocrinology, Peking University First Hospital, Beijing, China
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IgG4 was detected. AAL, Aleuria aurantia lectin; ConA, concanavalin A lectin; CON, healthy controls; GD, Graves’ disease; HT, Hashimoto’s thyroiditis; IgG, immunoglobulin G; IRA, Iris hybrid lectin (Dutch iris); LCA, Lens culinaris agglutinin
Tanja Diana
Tanja Diana
Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany
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Hans-Peter Holthoff
Hans-Peter Holthoff
AdvanceCor GmbH, Martinsried, Germany
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Julia Fassbender
Julia Fassbender
AdvanceCor GmbH, Martinsried, Germany
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Christian Wüster
Christian Wüster
Endocrine Laboratory and Practice Prof. Wüster, Mainz, Germany
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Michael Kanitz
Michael Kanitz
Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany
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George J. Kahaly
George J. Kahaly
Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany
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Martin Ungerer
Martin Ungerer
AdvanceCor GmbH, Martinsried, Germany
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TBAb) profile, levels of TSHR-binding inhibitory immunoglobulins (TBII) and free thyroxine (fT4) serum levels were measured and evaluated in a novel, long-term murine model for human GD using 7 repeated immunizations over 27 weeks with Ad-TSHR. These
Tanja Diana
Tanja Diana
Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany
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Paul D. Olivo
Paul D. Olivo
Department of Molecular Microbiology, Washington University Medical School, St. Louis, Missouri, USA
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Yie-Hwa Chang
Yie-Hwa Chang
Mediomics, LLC, St. Louis, Missouri, USA
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Christian Wüster
Christian Wüster
Endocrine Laboratory and Practice Prof. Wüster, Mainz, Germany
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Michael Kanitz
Michael Kanitz
Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany
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George J. Kahaly
George J. Kahaly
Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany
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adenyl cyclase-stimulating activity in immunoglobulin G of patients with Graves’ disease . J Clin Endocrinol Metab . 1976 Feb ; 42 ( 2 ): 341 – 54 . 10.1210/jcem-42-2-341 946604 0021-972X 22 Macchia E , Carayon P , Fenzi GF
