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-associated antigen that is expressed in all stages of the cell proliferative cycle except the G0 phase [ 7 ]. The expression of Ki-67 is generally evaluated immunohistochemically as a labeling index (LI) in tissue specimens. A high Ki-67 LI was associated with poor
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countries but showing a very dire prognosis ( 55 ). Clinicians should treat patients diagnosed with such variants carefully, even if no other high-risk features can be detected. Cell proliferating activity (Ki-67 labeling index (LI)) In 2010, Ito
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.” Therefore, ultrasonography can provide useful information on the preoperative diagnosis of follicular carcinoma in some patients. The MIB-1 or Ki-67 labeling index is generally regarded as a proliferative marker of tumor and normal tissues. Many researchers
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Institute of Pathology, Medical University of Graz, Graz, Austria
Institute for Clinical Pathology, Johannes Kepler University, Linz, Austria
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Department of Neuropathology, Institute of Pathology, Medical University of Graz, Graz, Austria
Department of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria
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chromogranin A and synaptophysin. In addition, the tumor cells revealed immunoreactivity for TSH and LH, but not for FSH, prolactin, GH, ACTH, or CD56. There was no mitotic activity and the Ki67 labeling index was less than 1%. Postoperatively, the patient
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Istituto Oncologico del Mediterraneo, Viagrande, Italy
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Istituto Oncologico del Mediterraneo, Viagrande, Italy
Department of Surgery, McGill University, St. Mary Hospital, Montreal, Québec, Canada
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proliferative index. Independently of the malignant serum used, we observed over 90% positivity for Ki67 (Fig. 2 c). However, attempts to characterize these tumors immunohistochemically failed to show any more differentiating features as they were negative
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Department of Nuclear Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China
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Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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associations with thyroglobulin expression, histological variants and Ki-67 index . Cancers 2021 13 3627 . ( https://doi.org/10.3390/cancers13143627 ) 37 Lai WA Hang JF Liu CY Bai Y Liu Z Gu H Hong S Pyo JY Jung CK Kakudo K PAX8
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, may not be favoured [ 4 , 7 ]. As intake of fish or dairy products is discretionary, iodization of table salt with KI or KIO 3 at a level of 20–40 mg/kg provides a useful method of achieving population cover [ 6 ]. Use of iodized table salt is only
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
Endocrinology Division, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland, USA
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a,b Drug (ref) Composite outcome (%) Clinical activity score (%) Proptosis (%) Diplopia (%) Disease relapse (weeks) IVGC (67, 68, 71, 72) 23–53 45–83 0–46 0–19 21–40% (week 12) MMF+IVGC (68) 63 80 No
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been established [ 42 , 43 ]. In addition, there are no reports showing whether these events are associated with tumor progression during AS. The Ki-67 labeling index is reported to be associated with progression during AS [ 44 ]; however, it is