M. Schlumberger
M. Schlumberger
Department of Nuclear Medicine and Endocrine Oncology, Institute Gustave-Roussy and University Paris Sud, Villejuif, France
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L. Bastholt
L. Bastholt
Department of Oncology, Odense University Hospital, Odense, Denmark
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H. Dralle
H. Dralle
Department of Surgery, Martin Luther University, Halle-Wittenberg Medical Faculty, Halle/Saale, Germany
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B. Jarzab
B. Jarzab
MSC Memorial Cancer Center and Institute of Oncology, Gliwice, Poland
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F. Pacini
F. Pacini
Department of Endocrinologia, University of Siena, Siena, Italy
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J.W.A. Smit
J.W.A. Smit
Department of Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands
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for months or even years, but diarrhea may be debilitating. Slow tumor growth is common, and distant metastases limited to a single organ may be considered for curative surgical resection or another local treatment modality. Patients with distant
Daniela Cavaco
Daniela Cavaco
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Sara Carvalhal
Sara Carvalhal
Department of General Surgery, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Valeriano Leite
Valeriano Leite
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
NOVA Medical School/ Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
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NOVA Medical School
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treatment in cutaneous metastases of PTC with improvement of local symptoms. Introduction The vast majority of thyroid cancers of follicular origin have a very favorable outcome, but 5–10% of the cases will develop metastatic disease [ 1 ]. The
Luigi Bartalena
Luigi Bartalena
Department of Clinical and Experimental Medicine, University of Insubria, Endocrine Unit, Ospedale di Circolo, Varese, Italy
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Lelio Baldeschi
Lelio Baldeschi
Department of Ophthalmology, Hospital Saint Luc, Catholic University of Louvain, Brussels, Belgium
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Kostas Boboridis
Kostas Boboridis
Ophthalmology Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
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Anja Eckstein
Anja Eckstein
Zentrum für Augenheilkunde, Universitätsklinikum Essen, Essen
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George J. Kahaly
George J. Kahaly
Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany
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Claudio Marcocci
Claudio Marcocci
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Petros Perros
Petros Perros
Department of Endocrinology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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Mario Salvi
Mario Salvi
Graves' Orbitopathy Center, Endocrinology, Fondazione Ca' Granda IRCCS, University of Milan, Milan, Italy
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Wilmar M. Wiersinga
Wilmar M. Wiersinga
Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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be managed in patients with GO, though not on the treatment of GO itself [ 4 ]. A number of randomized clinical trials on the treatment of GO have been published in the last few years, and their outcome has influenced substantially the management of
Laura Fugazzola
Laura Fugazzola
Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Rossella Elisei
Rossella Elisei
Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Dagmar Fuhrer
Dagmar Fuhrer
Department of Endocrinology, Diabetes and Metabolism, Endocrine Tumour Center at West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany
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Barbara Jarzab
Barbara Jarzab
Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Institute, Oncology Center, Gliwice Branch, Gliwice, Poland
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Sophie Leboulleux
Sophie Leboulleux
Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Université Paris Saclay, Villejuif, France
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Kate Newbold
Kate Newbold
Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, United Kingdom
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Jan Smit
Jan Smit
Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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that continuation of RAI treatment in this situation is not beneficial. A combination of RAI therapy for RAI-avid lesions and local treatment for one or a limited number of RAI refractory lesions may be considered in certain patients. Progression
Giovanni Mauri
Giovanni Mauri
Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy
Division of Interventional Radiology, European Institute of Oncology, IRCCS, Milan, Italy
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Division of Interventional Radiology, European Institute of Oncology, IRCCS, Milan, Italy
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Laszlo Hegedüs
Laszlo Hegedüs
Department of Endocrinology, Odense University Hospital, University of Southern Denmark, Odense, Denmark
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Steven Bandula
Steven Bandula
Interventional Oncology Service, University College Hospital, London, United Kingdom
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Roberto Luigi Cazzato
Roberto Luigi Cazzato
Department of Interventional Radiology, University Hospital of Strasbourg, Strasbourg, France
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Agnieszka Czarniecka
Agnieszka Czarniecka
The Oncologic and Reconstructive Surgery Clinic, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland
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Oliver Dudeck
Oliver Dudeck
Center for Microtherapy, Klinik Hirslanden, Zurich, Switzerland
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Laura Fugazzola
Laura Fugazzola
Department of Endocrinology and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Romana Netea-Maier
Romana Netea-Maier
Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Gilles Russ
Gilles Russ
Thyroid and Endocrine Tumors Unit, La Pitie-Salpetriere Hospital, Sorbonne University, Paris, France
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Göran Wallin
Göran Wallin
Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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Enrico Papini
Enrico Papini
Department of Endocrinology & Metabolism, Ospedale Regina Apostolorum, Albano, Italy
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]. Most DTCs are not aggressive tumors, as the disease-specific mortality rate is 0.7 and 0.5% per 100,000 person-years for women and men, respectively [ 1 ]. After successful initial treatment, local recurrences of PTC were registered during a 10-year
Janice Ser Huey Tan
Janice Ser Huey Tan
Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Timothy Kwang Yong Tay
Timothy Kwang Yong Tay
Department of Pathology, Singapore General Hospital, Singapore
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Enya Hui Wen Ong
Enya Hui Wen Ong
Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Michael Fehlings
Michael Fehlings
ImmunoScape, 1 Scotts Road #24-10, Singapore
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Daniel Shao-Weng Tan
Daniel Shao-Weng Tan
Division of Medical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Nadiah Binte Sukma
Nadiah Binte Sukma
Department of Pathology, Singapore General Hospital, Singapore
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Eileen Xueqin Chen
Eileen Xueqin Chen
Department of Pathology, Singapore General Hospital, Singapore
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Jen-Hwei Sng
Jen-Hwei Sng
Department of Pathology, Singapore General Hospital, Singapore
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Connie Siew Poh Yip
Connie Siew Poh Yip
Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Kok Hing Lim
Kok Hing Lim
Department of Pathology, Singapore General Hospital, Singapore
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Darren Wan-Teck Lim
Darren Wan-Teck Lim
Division of Medical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Narayanan Gopalakrishna Iyer
Narayanan Gopalakrishna Iyer
Division of Surgical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Jacqueline Siok Gek Hwang
Jacqueline Siok Gek Hwang
Department of Pathology, Singapore General Hospital, Singapore
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Melvin Lee Kiang Chua
Melvin Lee Kiang Chua
Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Mei-Kim Ang
Mei-Kim Ang
Division of Medical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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baseline and at the 6-month timepoint from patient 1 showing complete response at both local and distant metastatic sites at 6 months after treatment initiation. A. Thyroid bed. B. Left hilar lymph node. C and D. Muscle. Table 2 Treatment
Lars Folkestad
Lars Folkestad
Department of Endocrinology, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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Frans Brandt
Frans Brandt
Department of Internal Medicine, Hospital of Southern Jutland, Sønderborg, Denmark
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Thomas Brix
Thomas Brix
Department of Endocrinology, Odense University Hospital, Odense, Denmark
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Marianne Vogsen
Marianne Vogsen
Department of Oncology, Odense University Hospital, Odense, Denmark
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Lars Bastholt
Lars Bastholt
Department of Oncology, Odense University Hospital, Odense, Denmark
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Peter Grupe
Peter Grupe
Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark
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Jeanette Krogh Petersen
Jeanette Krogh Petersen
Department of Clinical Pathology, Odense University Hospital, Odense, Denmark
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Laszlo Hegedüs
Laszlo Hegedüs
Department of Endocrinology, Odense University Hospital, Odense, Denmark
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thyroidectomy for TC are very rare. In the following we present a case of a 68-year-old male with GD and metastatic TC (papillary adenocarcinoma of follicular type), where the presence of TRAB complicated treatment of the latter. The case report is presented in
Jaume Capdevila
Jaume Capdevila
Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology (VHIO), IOB Quiron-Teknon, Barcelona, Spain
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Desiree’ Deandreis
Desiree’ Deandreis
Department of Medical Sciences, Nuclear Medicine Unit, University of Turin, AOU Città della Salute e della Scienza, Turin, Italy
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Cosimo Durante
Cosimo Durante
Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
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Sophie Leboulleux
Sophie Leboulleux
Service of Endocrinology, Diabetology, University Hospital Geneve, Geneve, Switzerland
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Markus Luster
Markus Luster
Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany
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Romana Netea-Maier
Romana Netea-Maier
Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands
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Kate Newbold
Kate Newbold
Royal Marsden Hospital, London, United Kingdom
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Susanne Singer
Susanne Singer
Institute of Medical Biostatistics Epidemiology and Informatics (IMBEI), University Medical Center of Johannes Gutenberg University, Mainz, Germany
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Gerasimos P Sykiotis
Gerasimos P Sykiotis
Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
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Beate Bartes
Beate Bartes
Association “Vivre sans Thyroïde”, Léguevin, France
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Kate Farnell
Kate Farnell
Butterfly Thyroid Cancer Trust, Rowlands Gill, Tyne & Wear, UK
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Laura Deborah Locati
Laura Deborah Locati
Medical Oncology Unit, IRCCS ICS Maugeri, Pavia, Italy
Department of Internal Medicine and Therapeutics, University of Pavia, Italy
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Department of Internal Medicine and Therapeutics, University of Pavia, Italy
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). Different approaches may be considered on a case-by-case basis in real-life practice. For example, potentially high-risk or life-threatening lesions (e.g. lesion close to cavitate organs or encasing blood vessels) may require local treatment or the start of
Irene Campi
Irene Campi
Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
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Marco Dell’Acqua
Marco Dell’Acqua
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Elisa Stellaria Grassi
Elisa Stellaria Grassi
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Maria Cristina Vigone
Maria Cristina Vigone
Department of Paediatrics, IRCCS San Raffaele Hospital, Milan, Italy
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Luca Persani
Luca Persani
Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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main causes include congenital hypothyroidism (CH), previous surgery/ablative treatments, neck radiotherapy, hypothyroid phase of subacute or silent thyroiditis, or drugs affecting thyroid function such as iodine-rich drugs, cytokines, tyrosine kinases
Laszlo Hegedüs
Laszlo Hegedüs
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
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Andrea Frasoldati
Andrea Frasoldati
Division of Endocrinology, Arcispedale S. Maria Nuova, Reggio Emilia, Italy
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Roberto Negro
Roberto Negro
Division of Endocrinology, “V. Fazzi” Hospital, Lecce, Italy
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Enrico Papini
Enrico Papini
Division of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy
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hypothyroidism. Thyroid Cancer and Lymph Node Metastases TA as well as EA have been reported to offer promising results in the treatment of local recurrent and and/or persistent DTC [ 48 ]. The results of the present survey are, to some extent
