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Mafalda Marcelino Department of Endocrinology, Armed Forces University Hospital, Lisbon, Portugal
Department of Endocrinology, Portuguese Institute of Oncology, Lisbon, Portugal

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Pedro Marques Department of Endocrinology, Portuguese Institute of Oncology, Lisbon, Portugal

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Luis Lopes Department of Endocrinology, Armed Forces University Hospital, Lisbon, Portugal

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Valeriano Leite Department of Endocrinology, Portuguese Institute of Oncology, Lisbon, Portugal

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João Jácome de Castro Department of Endocrinology, Armed Forces University Hospital, Lisbon, Portugal

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]. Larger and prospective studies are required to evaluate this issue. Moreover, there are some data reporting unusual toxic thyroid carcinomas [ 9 ], and recent studies suggest that the frequency of malignancy in toxic multinodular goiter (TMNG) is

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Rui Guo Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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Bowen Zheng Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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Tao Wu Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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Yufan Lian Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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Tinghui Yin Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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Yuting He Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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Jingya Qin Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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Zhicheng Yao Department of General Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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Wen Xu Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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Jie Ren Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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criteria, 29 patients were excluded due to their previous history of thyroid surgery or radioactive iodine treatment. Ultimately, 185 patients were included ( Fig. 2 ). Figure 2 Flowchart of the retrospective study. MNG, multinodular goiter; RFA

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Tumay Ozgur Departments of Pathology, Mustafa Kemal University Medical Faculty, Hatay, Turkey

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Hasan Gokce Departments of Pathology, Mustafa Kemal University Medical Faculty, Hatay, Turkey

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Ihsan Ustun Endocrinology and Metabolism, Mustafa Kemal University Medical Faculty, Hatay, Turkey

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Mehmet Yaldiz Departments of Pathology, Mustafa Kemal University Medical Faculty, Hatay, Turkey

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Mehmet Mustafa Akin Departments of Pathology, Mustafa Kemal University Medical Faculty, Hatay, Turkey

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Cumali Gokce Endocrinology and Metabolism, Mustafa Kemal University Medical Faculty, Hatay, Turkey

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. What This Case Report Adds • An unusual case of Riedel thyroiditis in a patient with asymptomatic multinodular goiter and thyroid autoantibodies. • The true nature of thyroid pathology in this case was suggested by ultrasonography (not by fine

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Hippolyte Dupuis Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France
University of Lille, Lille, France

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Emilie Merlen Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France

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Arnaud Jannin Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France
University of Lille, Lille, France

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Philippe Jamme University of Lille, Lille, France
Department of Dermatology, Lille University Hospital, Lille, France

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Alexandre Fagart Department of Nuclear Medicine, Valenciennes Hospital Center, Valenciennes, France

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Marie-Christine Vantyghem Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France
University of Lille, Lille, France

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Miriam Ladsous Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France

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, which may lead to thyroid atrophy. Novel insights ICI-induced destructive thyroiditis can cause a significant volume reduction of goiter and thyroid nodules and inactivation of toxic nodules. Pre-existent nodule or multinodular

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Mohamed E. Ahmed Khartoum Teaching Hospital, Khartoum, Sudan
Departments of Medicine, Khartoum, Sudan

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Mohamed A. Mahgoub Khartoum Teaching Hospital, Khartoum, Sudan

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Mohamed G. Alnedar Khartoum Teaching Hospital, Khartoum, Sudan

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Seif I. Mahadi Khartoum Teaching Hospital, Khartoum, Sudan
Departments of Medicine, Khartoum, Sudan

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Maha Alzubeir Surgery, Faculty of Medicine, Khartoum, Sudan

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Lamyaa A.M. El Hassan University of Ahfad, Khartoum, Sudan

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ElWaleed M. Elamin Alzaeim Alazhari University, Khartoum, Sudan

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Ahmed Mohammed El Hassan University of Khartoum, Khartoum, Sudan

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solids. Upper gastrointestinal endoscopy was normal. There was some degree of ptosis that was detected retrospectively after the final diagnosis was made. General examination was unremarkable. Cervical examination showed a simple multinodular goiter

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Marek Niedziela Department of Pediatric Endocrinology and Rheumatology, Poznan University of Medical Sciences, Poznan, Poland

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Nelly Sabbaghian Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Québec, Canada

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Leanne de Kock Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Québec, Canada
Department of Human Genetics, McGill University, Montreal, Québec, Canada

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William D. Foulkes Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Québec, Canada
Department of Human Genetics, McGill University, Montreal, Québec, Canada

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a similar ultrasonographic pattern to papillary thyroid carcinoma should be considered in the differential diagnosis of an apparent thyroid nodule [ 1 , 2 ]. Thyroid disease, particularly multinodular goiter (MNG), is the most frequent feature

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Thomas Szabo Yamashita Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA

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Fady J. Baky Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA

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Travis J. McKenzie Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA

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Geoffrey B. Thompson Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA

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David R. Farley Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA

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Melanie L. Lyden Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA

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Benzon M. Dy Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA

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. Preoperative ultrasound showed that 83% of patients who underwent thyroidectomy had multinodular goiter, with a minority presenting solitary nodules. There were 9 (19%) patients diagnosed with thyroid cancer at a mean age of 28.5 years (16–41 years) and all

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Marko Stojanović Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia

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Sandra Pekić Faculty of Medicine, University of Belgrade
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia

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Mirjana Doknić Faculty of Medicine, University of Belgrade
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia

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Dragana Miljić Faculty of Medicine, University of Belgrade
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia

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Slavica Ćirić Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia

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Aleksandar Diklić Faculty of Medicine, University of Belgrade
Endocrine Surgery Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia

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Svetislav Tatić Faculty of Medicine, University of Belgrade
Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia

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Miloje Joksimović Clinic for Neurosurgery, Clinical Center of Serbia, Belgrade, Serbia

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Emilija Manojlović-Gačić Faculty of Medicine, University of Belgrade
Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia

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Milica Skender-Gazibara Faculty of Medicine, University of Belgrade
Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia

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Vera Popović Faculty of Medicine, University of Belgrade
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia

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local lymphadenopathy, was found. Physical examination was otherwise unremarkable. The patient had a long-standing euthyroid multinodular goiter since the age of 20. She reported no compressive symptoms and no past ultrasound (US) reports were available

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Francesco Quaglino General Surgery Unit, Turin, Italy

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Valentina Marchese General Surgery Unit, Turin, Italy

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Enrico Mazza Endocrinology and Metabolism Unit, Turin, Italy

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Cristina Gottero Endocrinology and Metabolism Unit, Turin, Italy

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Riccardo Lemini General Surgery Unit, Turin, Italy

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Stefano Taraglio Pathology Unit, Maria Vittoria Hospital ASL TO2, Turin, Italy

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influenced in his interpretation. In cases in which more than 1 FNA was performed, the patient's worst FNA category was given. In multinodular goiters, we biopsied the nodule with an echographic pattern more suggestive for malignancy (tumor capsular invasion

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Bernard Goichot Department of Internal Medicine, Endocrinology and Nutrition, Hôpitaux Universitaires de Strasbourg
FMTS, Faculté de Médecine, Université de Strasbourg, Strasbourg

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Stéphane Bouée CEMKA, Bourg La Reine

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Claire Castello-Bridoux Medical Affairs Department, Merck Serono, Lyon

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Philippe Caron Department of Endocrinology, Metabolic Diseases and Nutrition, Pôle Cardio-Vasculaire et Métabolique, CHU Larrey
Inserm U1037, Université Paul Sabatier, Toulouse, France

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attested to by some recent controversies [ 1 , 2 , 3 ]. In addition, regardless of etiology, at least for the 3 main causes, i.e., Graves disease (GD) (autoimmune HT), toxic multinodular goiter (MNG), and toxic adenoma (TA), which account for over 90% of HT

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