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Peter Laurberg Department of Endocrinology, Aalborg Hospital, Aalborg

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Nils Knudsen Medical Clinic I, Bispebjerg Hospital, Copenhagen, Denmark

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Stig Andersen Department of Endocrinology, Aalborg Hospital, Aalborg

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Allan Carlé Department of Endocrinology, Aalborg Hospital, Aalborg

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Inge Bülow Pedersen Department of Endocrinology, Aalborg Hospital, Aalborg

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Jesper Karmisholt Department of Endocrinology, Aalborg Hospital, Aalborg

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The obesity epidemic is a major threat to health in most countries [ 1 ], although the increase in the prevalence of obesity seems to have stopped in some countries according to recent investigations [ 2 , 3 ]. The international focus on

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000342994
Volume/Issue:
Volume 1: Issue 3
Free access
Érique José F. Peixoto de Miranda Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil

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Márcio Sommer Bittencourt Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil

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Itamar S. Santos Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil

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Paulo A. Lotufo Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil

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Isabela M. Benseñor Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil

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individuals with TSH values exceeding 7.0 mIU/l, and particularly above 10 mIU/l [ 6 ]. In spite of this controversy, some studies have linked SCH with hypertension [ 7 ], obesity [ 8 ], dyslipidemia [ 9 ], metabolic syndrome [ 10 ], insulin resistance [ 10

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000448683
Volume/Issue:
Volume 5: Issue 4
Free access
K. Alexander Iwen Medizinische Klinik I, Experimentelle und Klinische Endokrinologie, Universität zu Lübeck, Lübeck, Germany

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Erich Schröder Medizinische Klinik I, Experimentelle und Klinische Endokrinologie, Universität zu Lübeck, Lübeck, Germany

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Georg Brabant Medizinische Klinik I, Experimentelle und Klinische Endokrinologie, Universität zu Lübeck, Lübeck, Germany
Department of Endocrinology, The Christie Manchester Academic Health Science Centre, Manchester, UK

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insulin resistance as an essential causative factor, has been defined as the presence of visceral obesity with at least two of the following disorders: (1) raised triglyceride level or specific treatment, (2) reduced HDL cholesterol or specific treatment

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000351249
Volume/Issue:
Volume 2: Issue 2
Free access
Carolina Castro Porto Silva Janovsky Hospital Israelita Albert Einstein, Sao Paulo, Brazil
Department of Medicine, Thyroid Outpatient Clinic, Division of Endocrinology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Sao Paulo, Brazil

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Fernando H. Cesena Hospital Israelita Albert Einstein, Sao Paulo, Brazil

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Viviane Arevalo Tabone Valente Hospital Israelita Albert Einstein, Sao Paulo, Brazil

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Raquel Dilguerian de Oliveira Conceição Hospital Israelita Albert Einstein, Sao Paulo, Brazil

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Raul D. Santos Hospital Israelita Albert Einstein, Sao Paulo, Brazil
Lipid Clinic Heart Institute (InCor), University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil

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Márcio Sommer Bittencourt Hospital Israelita Albert Einstein, Sao Paulo, Brazil
School of Medicine, Faculdade Israelita de Ciências da Saúde Albert Einstein, Sao Paulo, Brazil
Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo School of Medicine, Sao Paulo, Brazil

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demonstrate this independent association. NAFLD is the most common liver disorder in Western industrialized countries and shares the same risk factors as type 2 diabetes, dyslipidemia, obesity, and metabolic syndrome [ 34 ]. Indeed, it may often be

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000492324
Volume/Issue:
Volume 7: Issue 6
Free access
Laura P.B. Elbers Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam

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Hjalmar A. Boon Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam

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Maaike I. Moes Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam

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Bregje van Zaane Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam

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Dees P.M. Brandjes Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam

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Eric Fliers Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam

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Harry R. Büller Departments of Vascular Medicine, University of Amsterdam, Amsterdam

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Suzanne Cannegieter Department of Clinical Epidemiology, Leiden University Medical Center
Einthoven Laboratory for Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Victor E.A. Gerdes Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam

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), former bleeding and obesity-associated comorbidities (diabetes, hypertension, dyslipidemia, obstructive sleep apnea), presence of other established risk factors for bleeding (heart failure, renal insufficiency, bleeding disorder, prior abdominal surgery

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000446431
Volume/Issue:
Volume 5: Issue 2
Open access
Mario Rotondi Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri I.R.C.C.S., ISPESL Laboratory for Endocrine Disruptors and Chair of Endocrinology, University of Pavia, Pavia

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Maria Grazia Castagna Departments of Medical, Surgical and Neurological Sciences, Siena

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Carlo Cappelli Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy

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Cristina Ciuoli Departments of Medical, Surgical and Neurological Sciences, Siena

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Francesca Coperchini Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri I.R.C.C.S., ISPESL Laboratory for Endocrine Disruptors and Chair of Endocrinology, University of Pavia, Pavia

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Francesco Chiofalo Departments of Medical, Surgical and Neurological Sciences, Siena

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Fabio Maino Departments of Medical, Surgical and Neurological Sciences, Siena

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Paola Palmitesta Departments of Social, Political and Cognitive Sciences, University of Siena, Siena

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Luca Chiovato Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri I.R.C.C.S., ISPESL Laboratory for Endocrine Disruptors and Chair of Endocrinology, University of Pavia, Pavia

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Furio Pacini Departments of Medical, Surgical and Neurological Sciences, Siena

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/or lifestyle factors [ 2 , 3 ]. Among well-recognized risk factors for thyroid cancer (previous radiation exposure, iodine intake, family history of thyroid disease and TSH levels), obesity has been added to the list of potential risk factors [ 4 ]. In the USA

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000445054
Volume/Issue:
Volume 5: Issue 2
Free access
Laura Croce Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy
Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy

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Fausta Beneventi Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia (PV), Italy

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Federica Ripepi Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy

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Irene De Maggio Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia (PV), Italy

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Alberto Malovini Istituti Clinici Scientifici Maugeri IRCCS, Laboratory of Informatics and Systems Engineering for Clinical Research, Pavia (PV), Italy

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Camilla Bellingeri Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia (PV), Italy

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Francesca Coperchini Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy

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Marsida Teliti Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy
Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy

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Mario Rotondi Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy
Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy

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Arsenio Spinillo Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia (PV), Italy

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Flavia Magri Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy
Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy

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iodine deficiency ( 13 ). Moreover, patients living with morbid obesity frequently experience a raised serum TSH, in the absence of positivity for thyroid autoantibodies and/or abnormal findings at thyroid ultrasound ( 14 ). The physiopathology and

Article Type:
Research Article
Collections:
Thyroid and reproduction
DOI:
https://doi.org/10.1530/ETJ-23-0213
Volume/Issue:
Volume 13: Issue 2
Open access
Hicham Benabdelkamel Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia

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Malak A Jaber Pharmaceutical Medicinal Chemistry & Pharmacognosy, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan

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Lina A Dahabiyeh Division of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Amman, Jordan

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Afshan Masood Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia

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Reem H Almalki Metabolomics Section, Department of Clinical Genomics, Center for Genome Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia

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Mohthash Musambil Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia

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Anas M Abdel Rahman Metabolomics Section, Department of Clinical Genomics, Center for Genome Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
Department of Medicine, College of Medicine and King Saud Medical City, King Saud University, Riyadh, Saudi Arabia

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Assim A Alfadda Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia
Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia

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(registration no. E-10-172). The recruited patients, referred to the KKUH Obesity Research Center, were asked to sign a written informed consent form before enrolment. Eighteen overweight patients (10 women and 8 men) with BMI ranging from 25 to 27 kg/m 2 who

Article Type:
Research Article
Collections:
Hypothyroidism
DOI:
https://doi.org/10.1530/ETJ-23-0062
Volume/Issue:
Volume 12: Issue 4
Open access
Victor J M Pop Department of Medical Psychology, Tilburg University, The Netherlands

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Johannes G Krabbe Department of Clinical Chemistry and Laboratory Medicine, Medisch Spectrum Twente, Medlon BV, Enschede, The Netherlands

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Maarten Broeren Department of Clinical Chemistry, Maxima Medical Centre, Veldhoven, The Netherlands

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Wilmar Wiersinga Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands

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Margaret P Rayman Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK

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/L ( Table 1 ). There were 222 (9.9%) obese women with a BMI >30 (WHO criteria). In Table 2 , the characteristics of the IH group are compared with that of the reference group. Table 2 Characteristics at 12 weeks gestation of 122 women with IH (FT4

Article Type:
Research Article
Collections:
Thyroid and reproduction
DOI:
https://doi.org/10.1530/ETJ-23-0163
Volume/Issue:
Volume 13: Issue 2
Open access
Lisa Volke Medical Department III-Endocrinology, Nephrology, and Rheumatology, University of Leipzig Medical Center, Leipzig, Germany
Department of Medicine, University of Leipzig, Leipzig, Germany

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Kerstin Krause Medical Department III-Endocrinology, Nephrology, and Rheumatology, University of Leipzig Medical Center, Leipzig, Germany
Department of Medicine, University of Leipzig, Leipzig, Germany

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a study of Reinehr et al. [ 11 ], TSH and T3 were reversibly related to body weight in patients before and after weight loss (obese patients) and weight gain (anorectic patients). However, treatment of obesity and related metabolic diseases with TH

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000508483
Volume/Issue:
Volume 10: Issue 1
Open access