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C. Mari Aparici Nuclear Medicine, Radiology Department, University of California San Francisco, UCSF
Nuclear Medicine, Radiology Department, San Francisco VA Medical Center, San Francisco, Calif., USA

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T. Liu Nuclear Medicine, Radiology Department, University of California San Francisco, UCSF

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cancer to a distant, nonregional lymphatic nodal station. Introduction Most thyroid cancers are differentiated, and are classified pathologically as papillary or follicular or variants of these. In the US, papillary thyroid cancer is the most

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Diana Borges Duarte Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal

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Vânia Benido Silva Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal

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Guilherme Assunção Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal

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André Couto Carvalho Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal

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Cláudia Freitas Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal

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patient. Electronic Health Registry and Primary Care data were used to determine the causes of death. Papillary thyroid cancer treatment and follow-up All patients underwent surgical treatment (total thyroidectomy or totalization of previous sub

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Andrea Palermo Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy

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Andrea Napolitano Department of Medical Oncology, Campus Bio-Medico University, Rome, Italy

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Daria Maggi Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy

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Anda Mihaela Naciu Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy

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Gaia Tabacco Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy

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Silvia Manfrini Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy

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Anna Crescenzi Department of Anatomic Pathology, Campus Bio-Medico University, Rome, Italy

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Chiara Taffon Department of Anatomic Pathology, Campus Bio-Medico University, Rome, Italy

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Francesco Pantano Department of Medical Oncology, Campus Bio-Medico University, Rome, Italy

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Bruno Vincenzi Department of Medical Oncology, Campus Bio-Medico University, Rome, Italy

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Guiseppe Tonini Department of Medical Oncology, Campus Bio-Medico University, Rome, Italy

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Daniele Santini Department of Medical Oncology, Campus Bio-Medico University, Rome, Italy

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Established Facts It is already known that papillary thyroid cancer arising in a background of Hashimoto thyroiditis shows increased programmed cell death-1 (PD-L1). It is already known that metastases to the thyroid gland are

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Chi-Yu Kuo Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan

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Po-Sheng Yang Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan

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Ming-Nan Chien Division of Endocrinology and Metabolism, Department of Internal Medicine, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan

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Shih-Ping Cheng Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan
Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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Introduction Papillary thyroid cancer (PTC) is the most common endocrine malignancy, and its incidence is rising worldwide. Although PTC generally follows an indolent course, an increase in the mortality rate for advanced-stage PTC has been

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Lan Wu State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

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Salvatore Vaccarella International Agency for Research on Cancer (IARC/WHO), Lyon, France

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Chen-Yang Feng Information Technology Center, Sun Yat-sen University Cancer Center, Guangzhou, China

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Luigino Dal Maso Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy

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Yu Chen State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

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Wei-Wei Liu Department of Head and Neck, Sun Yat-sen University Cancer Center, Guangzhou, China

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Miao-Bian Liang State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

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Zike Zhang Department of Laboratory Medicine, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China

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Jun Yang School of Public Health, Guangzhou Medical University, Guangzhou, China

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Su-Mei Cao State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

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Mengmeng Li State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

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not have caused them harm if it was left undiscovered ( 4 ). The progressive introduction and wide use of new diagnostic techniques have likely led to increased detection of low-risk tumors ( 5 ), particularly papillary thyroid cancer (PTC) subtypes

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Helmi Khadra Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana, USA

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Ahmed Deniwar Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana, USA

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Khuzema Mohsin Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana, USA

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Dominique Monlezun Tulane University School of Medicine, New Orleans, Louisiana, USA

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Emad Kandil Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana, USA

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Introduction The incidence of thyroid cancer has been steadily increasing in the United States. This has been attributed in part due to the increased detection of small papillary thyroid cancer (PTC) [ 1 ]. As most thyroid cancers initially

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Giacomo Sturniolo Department of Human Pathology of the Adult and Developmental Age “G. Barresi”

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Carles Zafon Department of Endocrinology, Diabetes, and Metabolism Research Unit, Vall d'Hebron Institut de Recerca (VHIR)

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Mariacarla Moleti Department of Experimental Medicine, University of Messina, Messina, Italy

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Josep Castellví Department of Pathology, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain

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Francesco Vermiglio Department of Experimental Medicine, University of Messina, Messina, Italy

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Jordi Mesa Department of Endocrinology, Diabetes, and Metabolism Research Unit, Vall d'Hebron Institut de Recerca (VHIR)

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Dong W, Zhang H, Li J, Guan H, He L, Wang Z, Shan Z, Teng W: Estrogen induces metastatic potential of papillary thyroid cancer cells through estrogen receptor α and β. Int J Endocrinol 2013;2013:941568. 10.1155/2013/941568 24222765 9 Hiasa Y

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Luca Damiani Department of Medical Sciences, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy

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Sabrina Lupo Endocrine Unit, Azienda Ospedaliero-Universitaria di Ferrara, Cona/Ferrara, Italy

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Roberta Rossi Endocrine Unit, Azienda Ospedaliero-Universitaria di Ferrara, Cona/Ferrara, Italy

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Stefania Bruni Endocrine Unit, Azienda Ospedaliero-Universitaria di Ferrara, Cona/Ferrara, Italy

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Mirco Bartolomei Nuclear Medicine Unit, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italy

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Stefano Panareo Nuclear Medicine Unit, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italy

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Paola Franceschetti Endocrine Unit, Azienda Ospedaliero-Universitaria di Ferrara, Cona/Ferrara, Italy

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Paolo Carcoforo Department of Morphology, Section of Surgery, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy

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Giovanni Lanza Department of Medical Sciences, Pathology Unit, University of Ferrara, Ferrara, Italy

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Stefano Pelucchi Department of Biomedical and Surgical Specialization Sciences, University of Ferrara, Ferrara, Italy

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Ettore Degli Uberti Department of Medical Sciences, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy
Endocrine Unit, Azienda Ospedaliero-Universitaria di Ferrara, Cona/Ferrara, Italy

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Maria Chiara Zatelli Department of Medical Sciences, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy
Endocrine Unit, Azienda Ospedaliero-Universitaria di Ferrara, Cona/Ferrara, Italy

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alternative events in the etiopathogenesis of PTC. Oncogene 2003; 22: 4578–4580. 4 Omry-Orbach G: Risk stratification in differentiated thyroid Cancer: an ongoing process. Rambam Maimonides Med J 2016; 7. 5 Xing M: BRAF mutation in papillary

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Neslihan Kurtulmus Endocrinology and Thyroid Clinic, Acibadem Maslak Hospital, Istanbul, Turkey

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Burak Ertas Departments of Otorhinolaryngology, Istanbul, Turkey

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Yesim Saglican Pathology, Medical Faculty, Acibadem University, Istanbul, Turkey

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Hakan Kaya Endocrinology and Thyroid Clinic, Acibadem Maslak Hospital, Istanbul, Turkey

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Umit Ince Pathology, Medical Faculty, Acibadem University, Istanbul, Turkey

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Mete Duren Endocrinology and Thyroid Clinic, Acibadem Maslak Hospital, Istanbul, Turkey

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Introduction Papillary thyroid cancer (PTC) is the most common type of endocrine cancer [ 1 ]. It originates from follicular epithelial cells and usually has a slow progression with a good prognosis. However, of note, it presents with a high

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Saleha Babli Division of Endocrinology and Metabolism, Department of Medicine, Montreal General Hospital, McGill University, Montreal, Québec, Canada
Department of Endocrinology and Diabetes, Prince Sultan Military Medical City, Riyadh, Saudi Arabia

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Richard J.  Payne Department of Otolaryngology, Royal Victoria Hospital, McGill University, Montreal, Québec, Canada

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Elliot Mitmaker Department of Surgery, Montreal General Hospital, McGill University, Montreal, Québec, Canada

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Juan Rivera Division of Endocrinology and Metabolism, Department of Medicine, Montreal General Hospital, McGill University, Montreal, Québec, Canada

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Introduction Papillary thyroid cancer (PTC) is the most common form of thyroid cancer, comprising approximately 80% of all thyroid cancers [ 1 , 2 ]. Chronic lymphocytic thyroiditis (CLT) is an autoimmune disease characterized by widespread

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