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Min Ji Jeon Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Won Gu Kim Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Ki-Wook Chung Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Jung Hwan Baek Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Won Bae Kim Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Young Kee Shong Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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carcinomas (PTCs) including papillary thyroid microcarcinomas (PTMCs) [ 1 , 2 ]. For the last several decades, we did not have sufficient knowledge of the biological behavior of PTMCs, and were surprised to find that many of these PTMCs have similar

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F. Cecoli Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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E.M. Ceresola Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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V. Altrinetti Endocrinology and Nuclear Medicine, Galliera Hospital, Genoa

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M. Cabria Endocrinology and Nuclear Medicine, Galliera Hospital, Genoa

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M. Cappagli Endocrine Unit, Sant'Andrea Hospital, La Spezia

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A. Montepagani Endocrine Unit, Sant'Andrea Hospital, La Spezia

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C.M. Cuttica Endocrinology and Nuclear Medicine, Galliera Hospital, Genoa

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U. Filippi Evangelico Internazionale Hospital, Genoa

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D. Saverino Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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M. Raffa Endocrine-Metabolic Center, ASL 1, Imperia, Italy

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M. Caputo Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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F. Minuto Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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M. Giusti Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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M. Bagnasco Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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Introduction The incidence of papillary thyroid cancer (PTC) has almost doubled over the last three decades mainly due to the higher incidence of papillary thyroid microcarcinoma (MPTC) [ 1 , 2 ]. In Italy, a remarkably high PTC incidence has

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Ho-Ryun Won Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea
Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University Sejong Hospital, Sejong, Republic of Korea

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Min Gyu Kim Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea

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Min Soo Kim Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea

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Jae Won Chang Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea
Department of Otolaryngology-Head and Neck Surgery, Chungnam National University Hospital, Daejeon, Republic of Korea

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Bon Seok Koo Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea
Department of Otolaryngology-Head and Neck Surgery, Chungnam National University Hospital, Daejeon, Republic of Korea

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increase in papillary thyroid microcarcinoma (PTMC), defined as papillary thyroid carcinoma less than 1 cm; accordingly, concerns have been raised regarding overdiagnosis ( 6 , 7 ). Another characteristic of thyroid cancer is indolent progression

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Pedro Weslley Souza Rosario Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Gabriela Franco Mourão Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Pedro Henrique Lopes Oliveira Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Tulio Henrique Silva Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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shows that surgery can detect features associated with a poor prognosis in adults with a preoperative diagnosis of “nonaggressive papillary microcarcinoma restricted to the thyroid,” and thus potential candidates for AS [ 1 - 5 ]. How often this occurs

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Maria Rossing Department of Endocrinology, Herlev University Hospital, Herlev
Center of Genomic Medicine, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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Birte Nygaard Department of Endocrinology, Herlev University Hospital, Herlev

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Finn Cilius Nielsen Center of Genomic Medicine, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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Finn Noe Bennedbæk Department of Endocrinology, Herlev University Hospital, Herlev

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Frates et al. [ 7 ] the accumulated predicted value of US characteristics and basic clinical features ranged between 3 and 48%. The papillary thyroid microcarcinoma (PTMC) is a papillary thyroid carcinoma with a size of ≤1 cm. The overall incidence of

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Pedro Weslley Souza Rosario Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Dear Editor, Recently, Russ et al. [ 1 ] endorsed active surveillance for low-risk papillary microcarcinoma of the thyroid (PMT). It is also reasonable to imagine that, if immediate treatment is not necessary, fine-needle aspiration (FNA) of

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Haggi Mazeh Department of Surgery, Jerusalem, Israel

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Amir Orlev Department of Surgery, Jerusalem, Israel

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Ido Mizrahi Department of Surgery, Jerusalem, Israel

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David J. Gross Endocrinology and Metabolism Service Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Herbert R. Freund Department of Surgery, Jerusalem, Israel

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case for all micromedullary tumors. In one study, calcitonin levels were only elevated in tumors larger than 0.5 cm [ 14 ]. In contrast to MTC, the incidence of incidental papillary thyroid microcarcinoma is common, well documented and investigated

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Dillwyn Williams Department of Public Health, University of Cambridge, Cambridge, UK

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to the progression of papillary microcarcinoma of the thyroid under observation. Thyroid 2014;24:27-34. 10.1089/thy.2013.0367 24001104 40 So YK, Son YI, Hong SD: Subclinical lymph node metastasis in papillary thyroid microcarcinoma: a study of

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Amanda La Greca Endocrinology Service, Department of Medicine, New York, N.Y., USA

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Bin Xu Department of Pathology, Memorial Sloan-Kettering Cancer Center and Weill-Cornell College of Medicine, New York, N.Y., USA

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Ronald Ghossein Department of Pathology, Memorial Sloan-Kettering Cancer Center and Weill-Cornell College of Medicine, New York, N.Y., USA

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R. Michael Tuttle Endocrinology Service, Department of Medicine, New York, N.Y., USA

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Mona M. Sabra Endocrinology Service, Department of Medicine, New York, N.Y., USA

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[ 1 , 2 , 3 ]. Multifocal papillary thyroid carcinomas (PTC) can be divided into 2 categories depending on the tumor size: multifocal papillary microcarcinoma (all of the lesions sized <1 cm) and multifocal macroscopic papillary thyroid cancer

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Marta Nascimento Soares Faculty of Medicine of the University of Porto, Porto, Portugal

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Marta Borges-Canha Faculty of Medicine of the University of Porto, Porto, Portugal
Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, Porto, Portugal
Department of Surgery and Physiology, Cardiovascular Research Unit, Faculty of Medicine from the University of Porto, Porto, Portugal

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Celestino Neves Faculty of Medicine of the University of Porto, Porto, Portugal
Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, Porto, Portugal
Institute for Research Innovation in Health, University of Porto, Porto, Portugal

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João Sérgio Neves Faculty of Medicine of the University of Porto, Porto, Portugal
Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, Porto, Portugal
Department of Surgery and Physiology, Cardiovascular Research Unit, Faculty of Medicine from the University of Porto, Porto, Portugal

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Davide Carvalho Faculty of Medicine of the University of Porto, Porto, Portugal
Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, Porto, Portugal
Institute for Research Innovation in Health, University of Porto, Porto, Portugal

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papillary carcinomas, and 1 (5.6%) was NIFTP (non-invasive follicular thyroid neoplasm with papillary-like nuclear features). Of the 10 microcarcinomas, 3 were discovered on preoperatory FNA, 1 discovered by FNA of a cervical lymph node, and 6 were an

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