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Kevin Stroek Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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Annemieke C. Heijboer Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands

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Marja van Veen-Sijne Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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Annet M. Bosch Division of Metabolic Disorders, Department of Pediatrics, Emma Children’s Hospital, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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Catharina P.B. van der Ploeg Department of Child Health, Netherlands Organization for Applied Scientific Research TNO, Leiden, The Netherlands

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Nitash Zwaveling-Soonawala Department of Paediatric Endocrinology, Emma Children’s Hospital, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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Robert de Jonge Department of Clinical Chemistry, Amsterdam UMC, Vrije Universiteit & University of Amsterdam, Amsterdam, The Netherlands

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A.S. Paul van Trotsenburg Department of Paediatric Endocrinology, Emma Children’s Hospital, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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Anita Boelen Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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[ 6 ], optimization of the Dutch NBS for detection of CH-C is warranted to improve its specificity. Reference intervals (RIs) for diagnostic tests are crucial for the interpretation of the measurements. A RI is based on measurement of a laboratory test

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000513516
Volume/Issue:
Volume 10: Issue 3
Open access
Marta Kostecka-Matyja Chair and Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow

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Anna Fedorowicz Chair and Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow

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Ewa Bar-Andziak Department of Internal Medicine and Endocrinology, Medical University, Warsaw

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Tomasz Bednarczuk Department of Internal Medicine and Endocrinology, Medical University, Warsaw

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Monika Buziak-Bereza Chair and Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow

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Paulina Dumnicka Department of Medical Diagnostics, Jagiellonian University, Collegium Medicum, Krakow

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Maria Górska Department of Endocrinology, Diabetology and Internal Medicine, Medical University, Bialystok

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Małgorzata Krasnodębska Department of Internal Medicine and Endocrinology, Medical University, Warsaw

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Beata Niedźwiedzka Department of Internal Medicine and Endocrinology, Medical University, Warsaw

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Dorota Pach Chair and Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow

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Marek Ruchała Department of Endocrinology, Metabolism and Internal Medicine, University of Medical Sciences, Poznan

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Katarzyna Siewko Department of Endocrinology, Diabetology and Internal Medicine, Medical University, Bialystok

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Bogdan Solnica Department of Diagnostics, Chair of Clinical Biochemistry, Jagiellonian University, Collegium Medicum, Krakow, Poland

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Jerzy Sowiński Department of Endocrinology, Metabolism and Internal Medicine, University of Medical Sciences, Poznan

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Małgorzata Szelachowska Department of Endocrinology, Diabetology and Internal Medicine, Medical University, Bialystok

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Małgorzata Trofimiuk-Müldner Chair and Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow

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Katarzyna Wachowiak-Ochmańska Department of Endocrinology, Metabolism and Internal Medicine, University of Medical Sciences, Poznan

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Alicja Hubalewska-Dydejczyk Chair and Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow

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secretion peak corresponds to the decrease in TSH secretion [ 11 ]. TSH levels during late pregnancy stay within the reference intervals determined for the general population, but in the first trimester it tends to be lower. The lowest TSH concentrations

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000453061
Volume/Issue:
Volume 6: Issue 2
Free access
Lise Husted Department of Clinical Biochemistry, Viborg Regional Hospital, Viborg, Denmark

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Sidsel Rødgaard-Hansen Department of Clinical Biochemistry, Viborg Regional Hospital, Viborg, Denmark

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Maja Hjelm Lundgaard Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

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Nanna Maria Uldall Torp Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

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Stine Linding Andersen Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

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shows considerable dynamics within the first trimester of a pregnancy which necessitates the use of pregnancy-specific reference intervals in the assessment of maternal thyroid function ( 3 ). In the kidney, an increase in renal plasma flow and the

Article Type:
Research Article
Collections:
Thyroid and reproduction
DOI:
https://doi.org/10.1530/ETJ-23-0157
Volume/Issue:
Volume 12: Issue 6
Open access
Simon H.S. Pearce Institute of Genetic Medicine, Newcastle University
Royal Victoria Infirmary, Newcastle upon Tyne, UK

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Georg Brabant Medizinische Klinik I, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany

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Leonidas H. Duntas Endocrine Unit, Evgenidion Hospital, University of Athens, Athens, Greece

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Fabio Monzani Department of Clinical and Experimental Medicine, Università di Pisa, Pisa, Italy

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Robin P. Peeters Rotterdam Thyroid Center, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Salman Razvi Institute of Genetic Medicine, Newcastle University
Queen Elizabeth Hospital, Gateshead, UK

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Jean-Louis Wemeau Clinique Endocrinologique Marc Linquette, CHU, Lille, France

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concentrations in a healthy individual have a much smaller variation over time, approximating to a third of the reference interval [ 14 ]. This can be conceptualised as an individual's ‘TSH setpoint'. Furthermore, follow-up of individuals using sequential TSH

Article Type:
Guideline
DOI:
https://doi.org/10.1159/000356507
Volume/Issue:
Volume 2: Issue 4
Free access
Stine Linding Andersen Department of Endocrinology, Aalborg University Hospital, Aarhus, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Aarhus, Denmark

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Jørn Olsen Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark

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Chun Sen Wu Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark

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Peter Laurberg Department of Endocrinology, Aalborg University Hospital, Aarhus, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Aarhus, Denmark

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interval (95% CI) for spontaneous abortion and stillbirth in pregnancies exposed to maternal hyperthyroidism versus the reference group with no maternal thyroid dysfunction registered up to 2 years after the pregnancy. In all analyses, robust standard error

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000365101
Volume/Issue:
Volume 3: Issue 3
Free access
Bernadette Biondi Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy

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Luigi Bartalena Department of Clinical and Experimental Medicine, University of Insubria, Endocrine Unit, Ospedale di Circolo, Varese, Italy

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David S. Cooper Division of Endocrinology, Diabetes, and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Md., USA

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Peter Laurberg Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark

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George J. Kahaly Department of Medicine I, Johannes Gutenberg University Medical Center, Mainz, Germany

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files and references of relevant articles and textbooks were also included. The task force critically assessed the literature and identified high-quality studies on SHyper. They evaluated study designs, the quality and consistency of the results, and the

Article Type:
Guideline
DOI:
https://doi.org/10.1159/000438750
Volume/Issue:
Volume 4: Issue 3
Free access
Heleen I Jansen Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands

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Antonius E van Herwaarden Radboud University Medical Center, Department of Laboratory Medicine, Nijmegen, The Netherlands

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Henk J Huijgen Department of Clinical Chemistry, Red Cross Hospital, Beverwijk, The Netherlands

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Rebecca C Painter Department of Obstetrics and Gynaecology, Amsterdam UMC Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands

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Jacquelien J Hillebrand Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands

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Anita Boelen Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands

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Annemieke C Heijboer Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands

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comparability of the fT4 assays enabling worldwide generalized reference intervals, will improve interpretation and will prevent miscommunication regarding fT4 results. However, there are other methodological quality aspects (like matrix effects in a pregnant

Article Type:
Research Article
Collections:
Thyroid and reproduction
DOI:
https://doi.org/10.1530/ETJ-22-0145
Volume/Issue:
Volume 11: Issue 6
Open access
Véronique Raverot Hospices Civils de Lyon, Groupement Hospitalier Est, LBMMS, Centre de biologie et de pathologie Est, Lyon, France

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Stéphanie Metrat Hospices Civils de Lyon, Groupement Hospitalier Est, LBMMS, Centre de biologie et de pathologie Est, Lyon, France

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Pauline Perrin Hospices Civils de Lyon, Groupement Hospitalier Est, LBMMS, Centre de biologie et de pathologie Est, Lyon, France

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Juliette Abeillon Hospices Civils de Lyon, Groupement Hospitalier Est, Fédération d’Endocrinologie, Lyon, France

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Hélène Lasolle Hospices Civils de Lyon, Groupement Hospitalier Est, Fédération d’Endocrinologie, Lyon, France

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context of constitutional thinness (TSH: 63.9 mUI/L (reference interval (RI): 0.27–4.2 mUI/L), free T4: 16 pmol/L (RI: 12.51–21.39 pmol/L), and free T3: 5.8 pmol/L (RI: 3.10–6.8 pmol/L); cobas analyser, Roche Diagnostics). Anti-thyroid peroxidase and anti

Article Type:
Case Report
Collections:
Thyroid function tests
DOI:
https://doi.org/10.1530/ETJ-24-0013
Volume/Issue:
Volume 13: Issue 3
Open access
Linda M. Thienpont Mass Spectrometry Reference Laboratory, Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium

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James D. Faix Clinical Chemistry and Immunology, Montefiore Medical Center, New York, N.Y., USA
Department of Pathology, Albert Einstein School of Medicine, New York, N.Y., USA

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Graham Beastall International Federation of Clinical Chemistry and Laboratory Medicine, Milan, Italy

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assays to use common reference intervals or decision limits for interpretation of results. However, in view of the Committee's approach to standardization/harmonization with clinically relevant patient samples, this recalibration basis will uniquely be

Article Type:
Letter
DOI:
https://doi.org/10.1159/000440614
Volume/Issue:
Volume 4: Issue 4
Free access
Wilmar M. Wiersinga Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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-called ‘reference population', the median TSH was 1.39 mU/l with a reference interval of 0.45-4.12 mU/l (P2.5-P97.5). However, a clear age-dependent effect on TSH values was observed: median TSH values and their reference ranges in the age groups 20-29, 60-69, 70

Article Type:
Editorial
DOI:
https://doi.org/10.1159/000438909
Volume/Issue:
Volume 4: Issue 3
Free access