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Yulia P. Sych Department of Endocrinology 1 at I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation

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Valentin V. Fadeev Department of Endocrinology 1 at I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation

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Elena P. Fisenko Laboratory of Ultrasound Diagnostics, Federal State Research Institution “B.V. Petrovsky National Research Centre of Surgery”, Moscow, Russian Federation

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Marina Kalashnikova Department of Endocrinology 1 at I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation

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. This further corresponds with the results of good reproducibility and interobserver agreement. Like a previous meta-analysis [ 16 ], the present study demonstrated that sensitivity of both Kw-TIRADS and EU-TIRADS for the diagnosis of thyroid

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Gilles Russ Thyroid and Endocrine Tumors, Institute of Endocrinology, Pitié Salpêtrière Hospital, Pierre and Marie Curie University, Paris, France

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Steen J. Bonnema Department of Endocrinology, Odense University Hospital, Odense, Denmark

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Murat Faik Erdogan Department of Endocrinology and Metabolism, University of Ankara School of Medicine, İbni Sina Hastanesi, Ankara, Turkey

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Cosimo Durante Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy

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Rose Ngu Head Neck and Thyroid Imaging, Department of Radiology, Guy’s and St Thomas’ Hospitals NHS Foundation Trust, London, United Kingdom

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Laurence Leenhardt Thyroid and Endocrine Tumors, Institute of Endocrinology, Pitié Salpêtrière Hospital, Pierre and Marie Curie University, Paris, France

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initial evaluation and follow-up of thyroid nodules and cancer. In order to enhance the interobserver reproducibility of descriptions and to simplify communication of the results, the ETA task force has issued a new simplified TIRADS, to be called EU

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Dorinda Mullen Department of Pathology, St. Vincent’s University Hospital, Dublin 4, Ireland

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Sarah Mullins Department of Pathology, St. Vincent’s University Hospital, Dublin 4, Ireland

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Aoife Doyle Department of Pathology, St. Vincent’s University Hospital, Dublin 4, Ireland

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Rachel K. Crowley Department of Endocrinology, St. Vincent’s University Hospital, Dublin 4, Ireland
School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland

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Stephen Skehan Department of Radiology, St. Vincent’s University Hospital, Dublin 4, Ireland
School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland

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Enda W. McDermott Department of Surgery, St. Vincent’s University Hospital, Dublin 4, Ireland
School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland

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Ruth S. Prichard Department of Surgery, St. Vincent’s University Hospital, Dublin 4, Ireland
School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland

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David Gibbons Department of Pathology, St. Vincent’s University Hospital, Dublin 4, Ireland
School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland

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cytomorphological features seen in AUS/FLUS (follicular lesion of undetermined significance) reporting and concluded that there is marked heterogeneity within the atypia category with resultant questionable reproducibility. Repeat FNA resulted in the

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Camille Galy-Bernadoy Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Hospital of Nîmes, Nîmes, France

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Benjamin Lallemant Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Hospital of Nîmes, Nîmes, France

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Guillaume Chambon Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Hospital of Nîmes, Nîmes, France

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Huy Trang Pham Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Hospital of Nîmes, Nîmes, France

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Christophe Reynaud Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Hospital of Nîmes, Nîmes, France

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Caroline Alovisetti Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Hospital of Nîmes, Nîmes, France

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Quentin Bonduelle Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Hospital of Nîmes, Nîmes, France

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Anne Marie Guedj Department of Endocrinology and Metabolic Diseases, University Hospital of Nîmes, Nîmes, France

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Serge Lumbroso Department of Biochemistry and Molecular Biology, University Hospital of Nîmes, Nîmes, France

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David-Paul De Brauwere Department of Biochemistry and Molecular Biology, University Hospital of Nîmes, Nîmes, France

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the adverse effects and limit the resulting additional costs. The value of determining serum parathyroid hormone (PTH) levels as a biological risk marker for hypoPTH occurrence is largely recognized, and the realization of this early assay (at the

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Daniel Rathmann Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Eddy Rijntjes Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Julika Lietzow Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Josef Köhrle Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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the alanine side chain [ 2 ]. Side chain deamination results in thyroacetic acids, whereas side chain decarboxylation generates the novel class of biologically active metabolites called thyronamines (TAM; see table 1 ). So far, only two

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Dong Gyu Na Department of Radiology, Human Medical Imaging and Intervention Center, Seoul, South Korea

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Hye Sook Min Departments of Pathology, Seoul, South Korea

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Hunkyung Lee Department of Pathology, Ewha Clinical Laboratory, Seoul, South Korea

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Jae-Kyung Won Departments of Pathology, Seoul, South Korea

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Hyo Bin Seo Department of Radiology, Seoul National University Hospital Kangnam Center, Seoul, South Korea

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Ji-Hoon Kim Radiology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea

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]. However, the role of RFNA for AUS/FLUS nodules is controversial. First, RFNA also reproduce significant inconclusive results. The rate of repeated AUS/FLUS results by RFNA is estimated to approximately be up to 67% [ 3 , 4 , 5 , 6 ]. Second, RFNA may not

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Ralf Paschke
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Silvia Cantara
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Anna Crescenzi
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Barbara Jarzab
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Thomas J. Musholt
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Manuel Sobrinho Simoes
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diagnostic performance of FNA cytology in the setting of indeterminate results has led to the search for diagnostic biomarkers, and several recently introduced molecular tests [ 9 ], such as gene expression classifier (GEC) [ 10 ], gene mutational panel [ 11

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Kassia B. Reuters Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil

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Maria C.O.C. Mamone Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil

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Elsa S. Ikejiri Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil

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Cleber P. Camacho Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil

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Claudia C.D. Nakabashi Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil

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Carolina C.P.S. Janovsky Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil

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Ji H. Yang Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil

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Danielle M. Andreoni Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil

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Rosalia Padovani Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
Santa Casa de São Paulo, São Paulo, Brazil

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Rui M.B. Maciel Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
Fleury Medicina e Saúde, São Paulo, Brazil

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Felipe A.B. Vanderlei Head and Neck Division, Department of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil

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Rosa P.M. Biscolla Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
Fleury Medicina e Saúde, São Paulo, Brazil

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near the thyroid gland in 0.7% (1/140). Discussion Prior to the Bethesda System for Reporting Thyroid Cytopathology, there was no standard classification and no application of reproducible cytological reporting of thyroid nodule FNA results

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Anke Schlüter Molecular Ophthalmology, Department of Ophthalmology, University Hospital Essen, Essen, Germany
Department of Oto-Rhino-Laryngology – Head and Neck Surgery, University Hospital Essen, Essen, Germany

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Anja K. Eckstein Molecular Ophthalmology, Department of Ophthalmology, University Hospital Essen, Essen, Germany
Department of Ophthalmology, University Hospital Essen, Essen, Germany

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Alexandra Brenzel Imaging Center Essen (IMCES), Institute for Experimental Immunology and Imaging, University Hospital Essen, Essen, Germany

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Mareike Horstmann Molecular Ophthalmology, Department of Ophthalmology, University Hospital Essen, Essen, Germany

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Stephan Lang Department of Oto-Rhino-Laryngology – Head and Neck Surgery, University Hospital Essen, Essen, Germany

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Utta Berchner-Pfannschmidt Molecular Ophthalmology, Department of Ophthalmology, University Hospital Essen, Essen, Germany

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J. Paul Banga Molecular Ophthalmology, Department of Ophthalmology, University Hospital Essen, Essen, Germany

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Salvador Diaz-Cano Department of Histopathology, King’s College Hospital NHS, London, United Kingdom

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of hyperplastic and autoimmune diseases are invaluable investigative tools for complex pathological conditions such as GD and autoimmune thyroiditis [ 5 - 7 ]. We have recently reported the development of a robust and reproducible model of

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Benjamin Lallemant Departments of Head and Neck Surgery, University Hospital of Nîmes, Nîmes
University of Montpellier I, Sud de France, Montpellier, France

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Guillaume Chambon Departments of Head and Neck Surgery, University Hospital of Nîmes, Nîmes

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Camille Galy-Bernadoy Departments of Head and Neck Surgery, University Hospital of Nîmes, Nîmes
University of Montpellier I, Sud de France, Montpellier, France

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Héliette Chapuis Departments of Pathology, University Hospital of Nîmes, Nîmes

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Anne-Marie Guedj Endocrinology, University Hospital of Nîmes, Nîmes

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Huy Trang Pham Departments of Head and Neck Surgery, University Hospital of Nîmes, Nîmes
University of Montpellier I, Sud de France, Montpellier, France

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Jean-Gabriel Lallemant Departments of Head and Neck Surgery, University Hospital of Nîmes, Nîmes
University of Montpellier I, Sud de France, Montpellier, France

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Damien Rupp Departments of Head and Neck Surgery, University Hospital of Nîmes, Nîmes
University of Montpellier I, Sud de France, Montpellier, France

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, surgical indications, surgeons training, number of thyroid surgery centre as well as the morphology of Korean people raise some questions concerning the reproducibility of these remarkable results elsewhere in the world. To date, only 9 reports of

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