Lei Xu
Lei Xu
Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, China
Xi’an Hospital of Traditional Chinese Medicine, Xi’an, China
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Xi’an Hospital of Traditional Chinese Medicine, Xi’an, China
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Junling Gao
Junling Gao
Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, China
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Quan Wang
Quan Wang
Laboratory of Surgical Oncology, Peking University People’s Hospital, Peking University, Beijing, China
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Jichao Yin
Jichao Yin
Xi’an Hospital of Traditional Chinese Medicine, Xi’an, China
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Pengfei Yu
Pengfei Yu
Xijing Hospital, Fourth Military Medical University, Xi’an, China
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Bin Bai
Bin Bai
Xijing Hospital, Fourth Military Medical University, Xi’an, China
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Ruixia Pei
Ruixia Pei
Xi’an Hospital of Traditional Chinese Medicine, Xi’an, China
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Dingzhang Chen
Dingzhang Chen
Xijing Hospital, Fourth Military Medical University, Xi’an, China
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Guochun Yang
Guochun Yang
Xi’an Hospital of Traditional Chinese Medicine, Xi’an, China
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Shiqi Wang
Shiqi Wang
Xijing Hospital, Fourth Military Medical University, Xi’an, China
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Mingxi Wan
Mingxi Wan
Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, China
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constructed. The pooled sensitivity, specificity, diagnostic odds ratio (DOR), and AUC with 95% CI were calculated using the bivariate model. Meta-regression analysis was not conducted, due to the small number of included studies. Publication bias was
Giorgio Grani
Giorgio Grani
Department of Translational and Precision Medicine, “Sapienza” University of Rome, Rome, Italy
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Livia Lamartina
Livia Lamartina
Department of Translational and Precision Medicine, “Sapienza” University of Rome, Rome, Italy
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Valeria Ramundo
Valeria Ramundo
Department of Translational and Precision Medicine, “Sapienza” University of Rome, Rome, Italy
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Rosa Falcone
Rosa Falcone
Department of Translational and Precision Medicine, “Sapienza” University of Rome, Rome, Italy
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Cristiano Lomonaco
Cristiano Lomonaco
Department of Translational and Precision Medicine, “Sapienza” University of Rome, Rome, Italy
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Laura Ciotti
Laura Ciotti
Department of Translational and Precision Medicine, “Sapienza” University of Rome, Rome, Italy
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Martina Barone
Martina Barone
Department of Translational and Precision Medicine, “Sapienza” University of Rome, Rome, Italy
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Marianna Maranghi
Marianna Maranghi
Department of Translational and Precision Medicine, “Sapienza” University of Rome, Rome, Italy
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Vito Cantisani
Vito Cantisani
Diagnostic and Ultrasound Innovations Unit, Azienda Ospedaliera Universitaria Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy
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Sebastiano Filetti
Sebastiano Filetti
Department of Translational and Precision Medicine, “Sapienza” University of Rome, Rome, Italy
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Cosimo Durante
Cosimo Durante
Department of Translational and Precision Medicine, “Sapienza” University of Rome, Rome, Italy
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system, the indication for FNAC under each of the test conditions (i.e., current vs. proposed definition of TTW) was defined as a test positivity. We assessed sensitivity, specificity, and the proportion of nodules classified as FNAC-deferrable (test
Nooshin Zargari
Nooshin Zargari
Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran
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Maral Mokhtari
Maral Mokhtari
Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran
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were recorded as negative. Only membranous staining of > 5% of the cells was considered positive: 1+ (5–25%), 2+ (26–50%), 3+ (51–75%), and 4+ (> 75%). Data analysis was done using SPSS 22. The sensitivity, specificity, positive predictive value (PPV
Zhaoqi Zhang
Zhaoqi Zhang
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
Department of Nuclear Medicine, The Fourth hospital of Hebei Medical University, Shijiazhuang, Hebei, China
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Department of Nuclear Medicine, The Fourth hospital of Hebei Medical University, Shijiazhuang, Hebei, China
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Josef Yu
Josef Yu
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Eva Rainer
Eva Rainer
Department of Biomedical Imaging and Image-guided Therapy, Division of General and Pediatric Radiology, Medical University of Vienna, Vienna, Austria
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Lindsay Hargitai
Lindsay Hargitai
Department of General Surgery, Medical University of Vienna, Vienna, Austria
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Zewen Jiang
Zewen Jiang
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Georgios Karanikas
Georgios Karanikas
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Tatjana Traub-Weidinger
Tatjana Traub-Weidinger
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Richard Crevenna
Richard Crevenna
Department of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna, Vienna, Austria.
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Marcus Hacker
Marcus Hacker
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Shuren Li
Shuren Li
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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patient-related sensitivity of 95% (77/81), specificity of 93% (26/28), and accuracy of 94% (103/109) ( Table 1 ). Table 1 Diagnostic efficiency of [ 18 F]F-DOPA PET. TP TN Sensitivity Specificity Accuracy PPV NPV
Tanja Diana
Tanja Diana
Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany
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Christian Wüster
Christian Wüster
Endocrine Laboratory Prof. Wüster, Mainz, Germany
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Paul D. Olivo
Paul D. Olivo
Department of Microbiology, Washington University, St. Louis, Missouri, USA
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Angelica Unterrainer
Angelica Unterrainer
Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany
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Jochem König
Jochem König
Endocrine Laboratory Prof. Wüster, Mainz, Germany
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Michael Kanitz
Michael Kanitz
Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany
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Artur Bossowski
Artur Bossowski
Department of Pediatrics, Endocrinology, and Diabetology, Medical University of Byalistok, Bialystok, Poland
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Brigitte Decallonne
Brigitte Decallonne
Division of Clinical and Experimental Endocrinology, UZ Leuven, Leuven, Belgium
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George J. Kahaly
George J. Kahaly
Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany
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sensitivity for the TSAb bioassay. Table 2. TBII binding assay and TSAb/TBAb bioassay values in 40 undiluted serum samples from patients with autoimmune thyroid disease Functional TSHR Antibody Specificity Ten TBAb-Positive AITD
Roussanka D. Kovatcheva
Roussanka D. Kovatcheva
Department of Endocrinology, Medical University of Sofia, Sofia, Bulgaria
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Alexander D. Shinkov
Alexander D. Shinkov
Department of Endocrinology, Medical University of Sofia, Sofia, Bulgaria
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Inna D. Dimitrova
Inna D. Dimitrova
Department of Endocrinology, Medical University of Sofia, Sofia, Bulgaria
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Ralitsa B. Ivanova
Ralitsa B. Ivanova
Department of Endocrinology, Medical University of Sofia, Sofia, Bulgaria
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Kalin N. Vidinov
Kalin N. Vidinov
Department of Endocrinology, Medical University of Sofia, Sofia, Bulgaria
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Radina S. Ivanova
Radina S. Ivanova
Department of Endocrinology, Medical University of Sofia, Sofia, Bulgaria
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to discriminate benign from malignant nodules, since cancer prevalence is 7–15% of all nodules [ 2 ]. US-guided fine-needle aspiration biopsy (FNAB) with cytology has high sensitivity and specificity in differentiating benign from malignant nodules
Yulia P. Sych
Yulia P. Sych
Department of Endocrinology 1 at I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation
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Valentin V. Fadeev
Valentin V. Fadeev
Department of Endocrinology 1 at I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation
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Elena P. Fisenko
Elena P. Fisenko
Laboratory of Ultrasound Diagnostics, Federal State Research Institution “B.V. Petrovsky National Research Centre of Surgery”, Moscow, Russian Federation
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Marina Kalashnikova
Marina Kalashnikova
Department of Endocrinology 1 at I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation
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moderate sensitivity (76.19–79.49%) and higher specificity (56.76–57.89%). The rate of unnecessary FNAB comprised 64.04–53.51% with EU-TIRADS and 42.11% with Kw-TIRADS (online suppl. Table 2). Discussion Ultrasound examination traditionally is
Kristine Z Swan
Kristine Z Swan
Department of ORL, Head- and Neck Surgery, Aarhus University Hospital, Aarhus, Denmark
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Johnson Thomas
Johnson Thomas
Department of Endocrinology, Mercy Hospital, Springfield, Missouri, USA
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Viveque E Nielsen
Viveque E Nielsen
Department of ORL, Head- and Neck Surgery, Odense University Hospital, Odense, Denmark
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Marie Louise Jespersen
Marie Louise Jespersen
Department of Pathology, Aarhus University Hospital, Aarhus, Denmark
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Steen J Bonnema
Steen J Bonnema
Department of Endocrinology, Odense University Hospital, Odense, Denmark
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similar to the test image, and the associated diagnosis is displayed to the physician for decision-making. In the initial internal validation study of AIBx, the negative predictive value (NPV) of the AIBx was 93.2%, while sensitivity, specificity, PPV, and
Luca Persani
Luca Persani
Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milano, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milano, Italy
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milano, Italy
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Patrice Rodien
Patrice Rodien
Service d’Endocrinologie-Diabétologie-Nutrition, Centre de référence des maladies rares de la Thyroïde et des récepteurs hormonaux, CHU d’Angers, Angers, France.
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Carla Moran
Carla Moran
Institute of Metabolic Science, University of Cambridge, Cambridge, UK
Endocrine Section, Beacon Hospital, Dublin, Ireland.
School of Medicine, University College Dublin, Ireland
Endocrinology Department, St Vincent’s University Hospital, Dublin, Ireland
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Endocrine Section, Beacon Hospital, Dublin, Ireland.
School of Medicine, University College Dublin, Ireland
Endocrinology Department, St Vincent’s University Hospital, Dublin, Ireland
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W Edward Visser
W Edward Visser
Department of Internal Medicine and Rotterdam Thyroid Center, Erasmus University Medical Center, Rotterdam, The Netherlands
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Stefan Groeneweg
Stefan Groeneweg
Department of Internal Medicine and Rotterdam Thyroid Center, Erasmus University Medical Center, Rotterdam, The Netherlands
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Robin Peeters
Robin Peeters
Department of Internal Medicine and Rotterdam Thyroid Center, Erasmus University Medical Center, Rotterdam, The Netherlands
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Samuel Refetoff
Samuel Refetoff
Departments of Medicine and Paediatrics and Committee on Genetics, The University of Chicago, Chicago, Illinois, USA
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Mark Gurnell
Mark Gurnell
Institute of Metabolic Science, University of Cambridge, Cambridge, UK
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Paolo Beck-Peccoz
Paolo Beck-Peccoz
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milano, Italy
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Krishna Chatterjee
Krishna Chatterjee
Institute of Metabolic Science, University of Cambridge, Cambridge, UK
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; altered color vision sensitivity Audiometry; AABR tests; Farnsworth–Munsell 100 Hue test with calculation of total error score; light- and darkness-adapted electroretinograms (ERG), with cone-specific chromatic stimuli. Neurological and cognitive
Tamas Solymosi
Tamas Solymosi
Endocrinology and Metabolism Clinic, Bugat Hospital, Gyöngyös, Hungary
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Laszlo Hegedüs
Laszlo Hegedüs
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
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Steen Joop Bonnema
Steen Joop Bonnema
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
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Andrea Frasoldati
Andrea Frasoldati
Endocrinology Unit of Arcispedale S. Maria Nuova, Reggio Emilia, Italy
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Laszlo Jambor
Laszlo Jambor
Department of Radiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
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Gabor Laszlo Kovacs
Gabor Laszlo Kovacs
1st Department of Medicine, Flohr Ferenc Hospital, Kerepestarcsa, Hungary
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Enrico Papini
Enrico Papini
Regina Apostolorum Hospital in Albano, Rome, Italy
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Karoly Rucz
Karoly Rucz
1st Department of Medicine, University of Pecs, Pecs, Hungary
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Gilles Russ
Gilles Russ
Unité Thyroïde et Tumeurs Endocrines – Pr Leenhardt Hôpital La Pitie Salpetriere, Sorbonne Université, Paris, France
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Zsolt Karanyi
Zsolt Karanyi
Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
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Endre V. Nagy
Endre V. Nagy
Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
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of PERS and TIRSYS methodologies in relation to the largest diameter of the nodules. Statistical Methods Sensitivities, specificities, and the 95% confidence intervals of the approaches tested (TIRSYS and PERS) were calculated against the 3
