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Carolina Castro Porto Silva Janovsky Hospital Israelita Albert Einstein, Sao Paulo, Brazil
Department of Medicine, Thyroid Outpatient Clinic, Division of Endocrinology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Sao Paulo, Brazil

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Fernando H. Cesena Hospital Israelita Albert Einstein, Sao Paulo, Brazil

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Viviane Arevalo Tabone Valente Hospital Israelita Albert Einstein, Sao Paulo, Brazil

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Raquel Dilguerian de Oliveira Conceição Hospital Israelita Albert Einstein, Sao Paulo, Brazil

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Raul D. Santos Hospital Israelita Albert Einstein, Sao Paulo, Brazil
Lipid Clinic Heart Institute (InCor), University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil

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Márcio Sommer Bittencourt Hospital Israelita Albert Einstein, Sao Paulo, Brazil
School of Medicine, Faculdade Israelita de Ciências da Saúde Albert Einstein, Sao Paulo, Brazil
Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo School of Medicine, Sao Paulo, Brazil

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disease (NAFLD) or non-alcoholic steatohepatitis [ 10 , 11 ]. In fact, NAFLD has long been recognized as the hepatic feature of the metabolic syndrome [ 12 ]. This condition may lead to hepatic fibrosis, cirrhosis, and hepatocellular carcinoma if not

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Haggi Mazeh Department of Surgery, Jerusalem, Israel

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Amir Orlev Department of Surgery, Jerusalem, Israel

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Ido Mizrahi Department of Surgery, Jerusalem, Israel

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David J. Gross Endocrinology and Metabolism Service Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Herbert R. Freund Department of Surgery, Jerusalem, Israel

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ectoderm [ 6 ]. MTCs comprise 4-8% of all thyroid cancers. Most cases are sporadic (75%). However, 25% are due to autosomal dominant inheritance as part of the MEN 2 syndrome or familial MTC. These inherited tumors are caused by germline point mutations

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Thomas Szabo Yamashita Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA

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Fady J. Baky Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA

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Travis J. McKenzie Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA

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Geoffrey B. Thompson Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA

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David R. Farley Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA

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Melanie L. Lyden Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA

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Benzon M. Dy Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA

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of a distinct entity . Thyroid . 2011 Feb ; 21 ( 2 ): 135 – 44 . 10.1089/thy.2010.0226 21190448 1050-7256 8 Hall JE , Abdollahian DJ , Sinard RJ . Thyroid disease associated with Cowden syndrome: A meta-analysis . Head Neck

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Ilaria Muller Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Italy

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Anita Daturi Department of Clinical Sciences and Community Health, University of Milan, Italy

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Matteo Varallo Department of Clinical Sciences and Community Health, University of Milan, Italy

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Tiziana E Re Internal Medicine - High Intensity of Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Davide Dazzi Casa di Cura Val Parma SRL, Langhirano (Parmigiano: Langhiràn), Italy

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Sara Maioli Department of Clinical Sciences and Community Health, University of Milan, Italy

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Erica Crivicich Department of Clinical Sciences and Community Health, University of Milan, Italy

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Francesco Di Marco Department of Clinical Sciences and Community Health, University of Milan, Italy

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Virgilio Longari Nuclear Medicine Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Beatrice Dazzi Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Massimo Castellani Nuclear Medicine Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Giovanna Mantovani Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Italy

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Maura Arosio Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Italy

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Mario Salvi Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Introduction The pandemic of coronavirus disease 2019 (Covid-19), determined by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), originated in Wuhan (Hubei, China) in December 2019 and later spread worldwide ( 1 ). One of the

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Marek Niedziela Department of Pediatric Endocrinology and Rheumatology, Poznan University of Medical Sciences, Poznan, Poland

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Nelly Sabbaghian Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Québec, Canada

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Leanne de Kock Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Québec, Canada
Department of Human Genetics, McGill University, Montreal, Québec, Canada

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William D. Foulkes Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Québec, Canada
Department of Human Genetics, McGill University, Montreal, Québec, Canada

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, apart from MNG, it generally includes rare-to-very-rare entities [ 7 ]. DICER1 syndrome is caused by loss-of-function germline DICER1 alterations on chromosome 14q32.13 and exhibits an autosomal dominant pattern of inheritance [ 8 ]. Thyroid disease is

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Hirosuke Danno Division of Internal Medicine, Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan

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Eijun Nishihara Division of Internal Medicine, Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan

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Kazuyoshi Kousaka Division of Internal Medicine, Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan

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Tomohiko Nakamura Division of Internal Medicine, Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan

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Toshihiko Kasahara Division of Internal Medicine, Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan

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Takumi Kudo Division of Internal Medicine, Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan

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Mitsuru Ito Division of Internal Medicine, Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan

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Shuji Fukata Division of Internal Medicine, Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan

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Mitsushige Nishikawa Division of Internal Medicine, Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan

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Akira Miyauchi Division of Surgery and Director, Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan

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Introduction The Marine-Lenhart syndrome (MLS), first described by Charkes in 1972 [ 1 ], is now commonly defined as “a combination of Graves’ disease and autonomous functioning thyroid nodule(s) (AFTN)” [ 2 - 4 ]. Typical scintigraphic images

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Veeravich Jaruvongvanich Department of Internal Medicine, University of Hawaii, Honolulu, HI, USA
Department of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand

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Anawin Sanguankeo Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA
Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

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Sikarin Upala Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA
Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

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hormones also have a role in hepatic lipid metabolism and hepatic insulin resistance [ 8 ]. Thyroid dysfunction can lead to hyperlipidemia, obesity, and insulin resistance, which are components of metabolic syndrome [ 9 ]. Given the hepatic manifestation

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Zoe A. Efstathiadou Department of Endocrinology, ‘Hippokration' General Hospital of Thessaloniki, Thessaloniki, Greece

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Albana Sykja Department of Endocrinology, ‘Hippokration' General Hospital of Thessaloniki, Thessaloniki, Greece

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Panagiotis Anagnostis Department of Endocrinology, ‘Hippokration' General Hospital of Thessaloniki, Thessaloniki, Greece

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Athanasios Panagiotou Department of Endocrinology, ‘Hippokration' General Hospital of Thessaloniki, Thessaloniki, Greece

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Marina Kita Department of Endocrinology, ‘Hippokration' General Hospital of Thessaloniki, Thessaloniki, Greece

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What Is Known about This Topic? • New onset and exacerbation of autoimmune thyroid disease have been described after successful treatment of endogenous hypercortisolism. What Does This Case Report Add? • It seems that correction of

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Martina Tavarelli Unité Thyroïde Tumeurs Endocrines, Paris, France

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Julie Sarfati Unité Thyroïde Tumeurs Endocrines, Paris, France

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Christian De Gennes Service de Médecine Interne Immuno-clinique, Paris, France

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Julien Haroche Service de Médecine Interne 2, Paris, France

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Camille Buffet Unité Thyroïde Tumeurs Endocrines, Paris, France

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Cécile Ghander Unité Thyroïde Tumeurs Endocrines, Paris, France

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Jean Marc Simon Service de Radiothérapie, Paris, France

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Fabrice Ménégaux Service de Chirurgie Générale et Digestive, Groupe Hospitalier et Faculté de Médecine Pitié-Salpêtrière, Institut du Cancer, Université Pierre et Marie Curie, Paris, France

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Laurence Leenhardt Unité Thyroïde Tumeurs Endocrines, Paris, France

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What Is Known about This Topic? • Reported cases of hypertrophic osteoarthropathy (HOA) as a paraneoplastic syndrome associated with thyroid cancer are very rare. We report the first case of an unusual presentation of HOA and follicular

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L.A. Jonker Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands

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C.A. Lebbink Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

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M.C.J. Jongmans Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands

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R.A.J. Nievelstein Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Pediatric Radiology and Nuclear Medicine, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands

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J.H.M. Merks Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

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E.J.M. Nieveen van Dijkum Department of Surgery, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands

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T.P. Links Department of Endocrinology, University Medical Center Groningen, Groningen, The Netherlands

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N. Hoogerbrugge Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands

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A.S.P. van Trotsenburg Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Center, Amsterdam, The Netherlands

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H.M. van Santen Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

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diagram of extensive literature results. Search strategy, Pubmed, search terms: (Cowden syndrome OR Cowden disease OR Bannayan Riley Ruvalcaba syndrome OR PTEN hamartoma syndrome) AND (thyroid cancer OR thyroid carcinoma OR thyroid nodule OR thyroid

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