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  • TSH receptor stimulating antibodies x
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Bengt Hallengren Departments of Endocrinology, Skåne University Hospital, Malmö
Department of Clinical Sciences, Lund University, Lund, Sweden

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Tereza Planck Departments of Endocrinology, Skåne University Hospital, Malmö
Department of Clinical Sciences, Lund University, Lund, Sweden

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Peter Åsman Departments of Ophthalmology, Skåne University Hospital, Malmö
Department of Clinical Sciences, Lund University, Lund, Sweden

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Mikael Lantz Departments of Endocrinology, Skåne University Hospital, Malmö
Department of Clinical Sciences, Lund University, Lund, Sweden

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positive for TSH receptor blocking antibodies, followed by hyperthyroidism positive for TSH receptor-stimulating antibodies, after an episode of SAT. This was similar to our patient who developed TSH receptor antibodies and hypothyroidism, which remained

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000435915
Volume/Issue:
Volume 4: Issue 3
Free access
Caiyan Mo Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Han Chen Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Qi Zhang Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Ying Guo Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Liyong Zhong Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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binding of thyroid-stimulating hormone receptor antibodies (TRAb) to thyroid-stimulating hormone (TSH) receptors leads to unregulated thyroid hormone production independent of pituitary TSH, resulting in hyperthyroidism ( 1 ). Central hyperthyroidism is a

Article Type:
Review Article
Collections:
Hyperthyroidism and thyrotoxicosis
DOI:
https://doi.org/10.1530/ETJ-22-0223
Volume/Issue:
Volume 12: Issue 4
Open access
Tanja Diana Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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Paul D. Olivo Department of Molecular Microbiology, Washington University Medical School, St. Louis, Missouri, USA

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Yie-Hwa Chang Mediomics, LLC, St. Louis, Missouri, USA

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Christian Wüster Endocrine Laboratory and Practice Prof. Wüster, Mainz, Germany

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Michael Kanitz Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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George J. Kahaly Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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receptors per cell. In contrast, studies with the stimulating human monoclonal antibody (M22) [ 39 ] allow for comparison of the signal transduction of the two TSH-R. When stimulating with M22 MAb, the CHO-MC4 cells produced higher levels of cAMP and

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000504509
Volume/Issue:
Volume 9: Issue 2
Free access
Naohiro Araki Diagnostic Division, Otsuka Pharmaceutical Co. Ltd., Tokushima, Japan

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Mitsuru Iida Diagnostic Division, Otsuka Pharmaceutical Co. Ltd., Tokushima, Japan

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Nobuyuki Amino Department of Internal Medicine, Kuma Hospital, Kobe, Japan

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Shinji Morita Department of Internal Medicine, Kuma Hospital, Kobe, Japan

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Akane Ide Department of Internal Medicine, Kuma Hospital, Kobe, Japan

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Eijun Nishihara Department of Internal Medicine, Kuma Hospital, Kobe, Japan

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Mitsuru Ito Department of Internal Medicine, Kuma Hospital, Kobe, Japan

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Jun Saito Department of Medicine, Yokohama Rosai Hospital, Yokohama, Japan

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Tetsuo Nishikawa Department of Medicine, Yokohama Rosai Hospital, Yokohama, Japan

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Kiyonori Katsuragi Diagnostic Division, Otsuka Pharmaceutical Co. Ltd., Tokushima, Japan

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Akira Miyauchi Department of Internal Medicine, Kuma Hospital, Kobe, Japan

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-vitro conversion of blocking type anti-TSH receptor antibody to the stimulating type by anti-human IgG antibodies. Clin Endocrinol (Oxf) 1987;27:615-624. 10.1111/j.1365-2265.1987.tb01192.x 2897263 20 Tamaki H, Amino N, Iwatani Y, Tachi J, Kimura M, Mitsuda

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000371740
Volume/Issue:
Volume 4: Issue 1
Open access
Yasmine Abdellaoui Department of Internal Medicine, Foch Hospital, Suresnes, France

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Dimitra Magkou Department of Endocrinology and Nutrition, Ambroise Paré Universitary Hospital, Assistance Publique Hôpitaux de Paris, Boulogne, France

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Sofia Bakopoulou Department of Endocrinology and Nutrition, Ambroise Paré Universitary Hospital, Assistance Publique Hôpitaux de Paris, Boulogne, France

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Ramona Zaharia Department of Endocrinology and Nutrition, Ambroise Paré Universitary Hospital, Assistance Publique Hôpitaux de Paris, Boulogne, France

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Marie-Laure Raffin-Sanson Department of Endocrinology and Nutrition, Ambroise Paré Universitary Hospital, Assistance Publique Hôpitaux de Paris, Boulogne, France
EA 4340, Université Versailles Saint Quentin en Yvelines, UFR Simone Veil Santé, Montigny le Bretonneux, France

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Laure Cazabat Department of Endocrinology and Nutrition, Ambroise Paré Universitary Hospital, Assistance Publique Hôpitaux de Paris, Boulogne, France
EA 4340, Université Versailles Saint Quentin en Yvelines, UFR Simone Veil Santé, Montigny le Bretonneux, France

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tested for thyroid function. THRB , thyroid hormone receptor beta; FT3, free triiodothyronine; FT4, free thyroxine; TSH, thyrotropin; TG, thyroglobulin; TPO, thyroperoxidase; Ab, autoantibodies; TRAb, TSH receptor antibodies; wt, wild-type sequence; N

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000506424
Volume/Issue:
Volume 9: Issue 5
Free access
N. Papanikolaou Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK

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P. Perros Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK

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for free thyroid hormones) with positive TSH receptor antibodies (5 IU/l, upper limit of normal 1.5 IU/l, measured by an RIA-coated tube kit (RSR Ltd., Pentwyn, Cardiff) and negative thyroid peroxidase antibodies (7 IU/ml, normal range 0–34, Roche

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000343826
Volume/Issue:
Volume 1: Issue 4
Free access
Jan Calissendorff Department of Clinical Science and Education, Section of Endocrinology, Karolinska Institutet, Södersjukhuset, Sweden

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Emil Mikulski Department of Medicine, Mälarsjukhuset, Eskilstuna, Sweden
Centre for Clinical Research in Sörmland, Uppsala University, Uppsala, Sweden

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Erik H. Larsen National Food Institute, Technical University of Denmark, Søborg, Denmark

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Marika Möller Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden
Centre for Clinical Research in Sörmland, Uppsala University, Uppsala, Sweden

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factors, smoking and female gender increase the risk [ 2 ]. Thyroid receptor antibodies (TRAb) activate the thyroid hormone receptors and thereby enhance thyroxine synthesis. This antibody is also a marker for the disease, together with elevated thyroid

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000381768
Volume/Issue:
Volume 4: Issue 2
Free access
Tetsuya Hiraiwa Hiraiwa Thyroid Clinic, Ibaraki City
Department of Internal Medicine (I), Osaka Medical College, Takatsuki City

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Naoyuki Tsujimoto Department of Internal Medicine (I), Osaka Medical College, Takatsuki City

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Keiji Tanimoto Department of Internal Medicine (I), Osaka Medical College, Takatsuki City

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Jungo Terasaki Department of Internal Medicine (I), Osaka Medical College, Takatsuki City

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Nobuyuki Amino Kuma Hospital, Kobe, Japan

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Toshiaki Hanafusa Department of Internal Medicine (I), Osaka Medical College, Takatsuki City

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laboratory tests showing high values of free thyroxine (FT 4 ) and free tri-iodothyronine (FT 3 ), low levels of thyrotropin-stimulating hormone (TSH), increased TSH receptor antibody (TRAb) titer and/or thyroid-associated ophthalmopathy. PT was diagnosed by

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000350560
Volume/Issue:
Volume 2: Issue 2
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Camilla Bøgelund Larsen Department of Endocrinology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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Eva Rabing Brix Petersen Department of Clinical Biochemistry and Immunology, Hospital of Southern Jutland, Aabenraa, Denmark

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Martin Overgaard Department of Clinical Research, University of Southern Denmark, Odense, Denmark
Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark

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Steen Joop Bonnema Department of Endocrinology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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antibodies – mostly immunoglobulin G [ 1 , 2 ]. Macro-hormones, including macro-TSH, are considered biologically inactive, and only a small fraction of the total amount of TSH in plasma remains free [ 3 ]. Although being bound into such complexes, TSH is

Article Type:
Case Report
Collections:
Hypothyroidism
DOI:
https://doi.org/10.1159/000509184
Volume/Issue:
Volume 10: Issue 1
Free access
Mahdi Kamoun Endocrinology and Metabolism Department

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Michèle d'Herbomez Department of Nuclear Medicine, Lille University Hospital, Lille

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Christine Lemaire Department of Endocrinology, Regional Hospital of Béthune, Béthune

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Armelle Fayard Endocrinology and Metabolism Department

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Rachel Desailloud Endocrinology and Metabolism Department, Amiens University Hospital, Amiens, France

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Damien Huglo Department of Nuclear Medicine, Lille University Hospital, Lille

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Jean-Louis Wemeau Endocrinology and Metabolism Department

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, intercellular adhesion molecule-1, MHC class II) on thyrocytes [ 8 ]. In line with these hypotheses, Kageyama et al. [ 19 ] reported the case of a 21-year-old woman with TSHoma who had increases in both anti-TSH receptors antibody and thyroid-stimulating

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000355386
Volume/Issue:
Volume 3: Issue 1
Free access