Genfeng Yu
Genfeng Yu
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Siyang Liu
Siyang Liu
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Cheng Song
Cheng Song
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Qintao Ma
Qintao Ma
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Xingying Chen
Xingying Chen
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Yuqi Jiang
Yuqi Jiang
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Hualin Duan
Hualin Duan
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Yajun He
Yajun He
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Dongmei Wang
Dongmei Wang
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Heng Wan
Heng Wan
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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Jie Shen
Jie Shen
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China
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central sensitivity indices include the thyrotroph thyroxine resistance index (TT4RI) and TSH index (TSHI). The FT3/FT4 ratio reflects deiodinase activity and is a proxy for peripheral thyroid hormone sensitivity ( 21 ). Central resistance phenomena affect
Ying Sun
Ying Sun
Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China
Department of Endocrinology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China
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Department of Endocrinology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China
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Di Teng
Di Teng
Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China
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Lei Zhao
Lei Zhao
Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China
Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Heping District, Shenyang, Liaoning, China
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Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Heping District, Shenyang, Liaoning, China
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Xiaoguang Shi
Xiaoguang Shi
Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China
Department of Endocrinology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China
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Department of Endocrinology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China
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Yongze Li
Yongze Li
Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China
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Zhongyan Shan
Zhongyan Shan
Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China
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Weiping Teng
Weiping Teng
Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China
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sensitivity index (TT4RI) was calculated as: fT4 (pmol/L) · TSH (mIU/L) ( 11 ). The TSH index (TSHI) was calculated as: ln TSH (mIU/L) + 0.1345 · fT4 (pmol/L) ( 14 ). The TFQI is achieved by applying the population empirical cumulative distribution
Federica D’Aurizio
Federica D’Aurizio
Department of Laboratory Medicine, Institute of Clinical Pathology, University Hospital of Udine, Udine, Italy
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Alessia Biasotto
Alessia Biasotto
Department of Medicine, University of Udine, Udine, Italy
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Claudia Cipri
Claudia Cipri
Endocrinology, Metabolism and Clinical Nutrition Unit, University Hospital of Udine, Udine, Italy
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Franco Grimaldi
Franco Grimaldi
Endocrinology, Metabolism and Clinical Nutrition Unit, University Hospital of Udine, Udine, Italy
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Jessica Zucco
Jessica Zucco
Department of Laboratory Medicine, Institute of Clinical Pathology, University Hospital of Udine, Udine, Italy
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Stefania Marzinotto
Stefania Marzinotto
Department of Laboratory Medicine, Institute of Clinical Pathology, University Hospital of Udine, Udine, Italy
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Francesco Curcio
Francesco Curcio
Department of Laboratory Medicine, Institute of Clinical Pathology, University Hospital of Udine, Udine, Italy
Department of Medicine, University of Udine, Udine, Italy
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Department of Medicine, University of Udine, Udine, Italy
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Salvatore Benvenga
Salvatore Benvenga
Department of Clinical and Experimental Medicine, Endocrinology Section, University of Messina, Messina, Italy
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(DiaSorin S.p.A., Saluggia, Italy) obtaining normal values (TT3 = 1.42 and 2.50 nmol/L for the mother and the daughter, respectively; RI: 1.18–3.40; TT4 = 78.33 and 90.30 nmol/L for the mother and the daughter, respectively; RI: 57.6–161.3 nmol/L). These
Irene Campi
Irene Campi
Division of Endocrine and Metabolic Diseases and Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy
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Maura Agostini
Maura Agostini
Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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Federica Marelli
Federica Marelli
Division of Endocrine and Metabolic Diseases and Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy
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Tiziana de Filippis
Tiziana de Filippis
Division of Endocrine and Metabolic Diseases and Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy
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Beatriz Romartinez-Alonso
Beatriz Romartinez-Alonso
Department of Molecular and Cell Biology, Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, United Kingdom
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Odelia Rajanayagam
Odelia Rajanayagam
Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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Giuditta Rurale
Giuditta Rurale
Division of Endocrine and Metabolic Diseases and Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy
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Ilaria Gentile
Ilaria Gentile
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Federica Spagnolo
Federica Spagnolo
Unit of Endocrinology, University Hospital “G. Martino”, Messina, Italy
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Massimiliano Andreasi
Massimiliano Andreasi
Laboratorio Analisi Cliniche, Centro di Ricerche e Tecnologie Biomediche, IRCCS Istituto Auxologico Italiano, Cusano Milanino, Italy
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Francesco Ferraù
Francesco Ferraù
Unit of Endocrinology, University Hospital “G. Martino”, Messina, Italy
Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
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Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
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Salvatore Cannavò
Salvatore Cannavò
Unit of Endocrinology, University Hospital “G. Martino”, Messina, Italy
Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
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Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
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Laura Fugazzola
Laura Fugazzola
Division of Endocrine and Metabolic Diseases and Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Krishna V. Chatterjee
Krishna V. Chatterjee
Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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Luca Persani
Luca Persani
Division of Endocrine and Metabolic Diseases and Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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the TTR gene, encoding for transthyretin to exclude a familial dysalbuminemic hyperthyroxinemia, and we did not find any variant. We did not sequence the SERPINA7 as TT4 levels were increased (243.7 nmol/L, normal reference 69-141), thus excluding
Janice Ser Huey Tan
Janice Ser Huey Tan
Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Timothy Kwang Yong Tay
Timothy Kwang Yong Tay
Department of Pathology, Singapore General Hospital, Singapore
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Enya Hui Wen Ong
Enya Hui Wen Ong
Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Michael Fehlings
Michael Fehlings
ImmunoScape, 1 Scotts Road #24-10, Singapore
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Daniel Shao-Weng Tan
Daniel Shao-Weng Tan
Division of Medical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Nadiah Binte Sukma
Nadiah Binte Sukma
Department of Pathology, Singapore General Hospital, Singapore
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Eileen Xueqin Chen
Eileen Xueqin Chen
Department of Pathology, Singapore General Hospital, Singapore
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Jen-Hwei Sng
Jen-Hwei Sng
Department of Pathology, Singapore General Hospital, Singapore
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Connie Siew Poh Yip
Connie Siew Poh Yip
Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Kok Hing Lim
Kok Hing Lim
Department of Pathology, Singapore General Hospital, Singapore
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Darren Wan-Teck Lim
Darren Wan-Teck Lim
Division of Medical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Narayanan Gopalakrishna Iyer
Narayanan Gopalakrishna Iyer
Division of Surgical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Jacqueline Siok Gek Hwang
Jacqueline Siok Gek Hwang
Department of Pathology, Singapore General Hospital, Singapore
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Melvin Lee Kiang Chua
Melvin Lee Kiang Chua
Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Mei-Kim Ang
Mei-Kim Ang
Division of Medical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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; TT, total thyroidectomy; ; ; TPS, tumour proportion score. Outcome of treatment and adverse effects As of October 2022, with a median follow-up of 32.6 (IQR: 26.4–38.8) months, no patients were on active treatment. We observed an ORR
Bushra Shahida
Bushra Shahida
Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmö, Sweden
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Tereza Planck
Tereza Planck
Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes and Endocrinology, Skåne University Hospital, Malmö, Sweden
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Department of Diabetes and Endocrinology, Skåne University Hospital, Malmö, Sweden
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Peter Åsman
Peter Åsman
Department of Clinical Sciences, Ophthalmology, Lund University, Malmö, Sweden
Department of Ophthalmology, Skåne University Hospital, Malmö, Sweden
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Department of Ophthalmology, Skåne University Hospital, Malmö, Sweden
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Mikael Lantz
Mikael Lantz
Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes and Endocrinology, Skåne University Hospital, Malmö, Sweden
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Department of Diabetes and Endocrinology, Skåne University Hospital, Malmö, Sweden
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Introduction Deiodinase type 2 (DIO2) is an enzyme that catalyzes the production of the active form of thyroid hormone triiodothyronine (T3) from thyroxine (T4) and is important for maintaining intracellular T3 levels [ 1 ]. DIO2 is also
Ola Lindgren
Ola Lindgren
Department of Endocrinology, Lund University, Malmö, Sweden
Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden
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Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden
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Pernilla Asp
Pernilla Asp
Department of Oncology, Skåne University Hospital, Lund, Sweden
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Anna Sundlöv
Anna Sundlöv
Department of Oncology, Lund University, and Department of Clinical Sciences, Skåne University Hospital, Lund, Sweden
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Jan Tennvall
Jan Tennvall
Department of Oncology, Lund University, and Department of Clinical Sciences, Skåne University Hospital, Lund, Sweden
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Bushra Shahida
Bushra Shahida
Department of Clinical Sciences Malmö, and Diabetes and Endocrinology, Lund University, Malmö, Sweden
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Tereza Planck
Tereza Planck
Department of Endocrinology, Lund University, Malmö, Sweden
Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden
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Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden
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Peter Åsman
Peter Åsman
Department of Clinical Sciences Malmö, Ophthalmology, Lund University, and Department of Ophthalmology, Skåne University Hospital, Malmö, Sweden
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Mikael Lantz
Mikael Lantz
Department of Endocrinology, Lund University, Malmö, Sweden
Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden
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Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden
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[ 1 , 2 ] and environmental factors [ 3 ]. One strong risk factor is tobacco smoking, which results in higher TRAb at diagnosis of GD and during treatment with thiamazole than in nonsmokers [ 4 ]. It has also been shown that smokers treated with
Jandee Lee
Jandee Lee
Department of Surgery, Eulji University College of Medicine
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Woong Youn Chung
Woong Youn Chung
Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea
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and framework described for the indication, as well as on surgical tips [ 1 , 2 , 3 , 4 ]. The first step taken to improve robotic thyroid surgery was characterized by the rapid evolution of robotic surgical techniques and training programs [ 1 , 2 , 3
George J. Kahaly
George J. Kahaly
Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany
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Luigi Bartalena
Luigi Bartalena
Department of Medicine and Surgery, University of Insubria, Varese, Italy
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Lazlo Hegedüs
Lazlo Hegedüs
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
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Laurence Leenhardt
Laurence Leenhardt
Thyroid and Endocrine Tumors Unit, Pitié Salpêtrière Hospital, Sorbonne University, Paris, France
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Kris Poppe
Kris Poppe
Endocrine Unit, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Simon H. Pearce
Simon H. Pearce
Department of Endocrinology, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
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increased the recurrence risk after ATD withdrawal [ 146 , 147 ]. Maternal FT4 (or TT4) values should be maintained at the upper limit of the pregnancy-specific thyroid function tests [ 148 ]. During the third trimester, discontinuation of ATD is often
