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Department of Emergency Medicine, Maastricht University Medical Center, Maastricht, the Netherlands
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( 11 ) and lower compared to our currently used Tg IRMA. This study has two aims. Our first aim is to compare the Tg-IRMA and Tg-LC-MS/MS analytically in the presence of TgAbs. Our secondary aim is to compare the clinical interpretation based on the
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immunoradiometric assay kit (Thyroglobuline IRMA®; CISbio) was used for serum Tg measurement with a functional sensitivity level of 0.7 ng/mL. Automated anti-Tg Ab assays (Elecsys®; Roche diagnostics) were used to detect the presence of anti-Tg antibodies. All
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Institut National de la Recherche Médicale, UMR U895, University Nice-Sophia-Antipolis, Nice, France
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Institut National de la Recherche Médicale, UMR U895, University Nice-Sophia-Antipolis, Nice, France
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IRMA, Cis bio International, Gif-sur-Yvette, France). fT4, fT3, total T4, TSH and anti-Tg antibodies were measured by chemiluminescence (ADVIA Centaur, Siemens Healthcare Diagnostics, France), while rT3 was measured by radioimmunoassay (Pasteur
Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France
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Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France
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iodine deficiency (ID), with special attention to women of childbearing age [ 3 , 8 , 9 ]. One important issue is to determine to what extent the drop in maternal FT4 is caused by insufficient iodine intake. Based on maternal thyroglobulin (Tg) levels and
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The Rappaport Faculty of Medicine, Technion, Institute of Technology, Haifa, Israel
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for FT4, 10–20 pmol/L. Normal references for the first week of life in our laboratory were 0.4–10 mIU/L for TSH and 10–26.8 pmol/L for FT4. Tg and TPO antibodies (Ab) were measured by direct automated chemiluminescent IRMA using an Immulite 2000