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  • Thyroid remnant ablation x
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Ian D Hay Department of Medicine 1, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA

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Suneetha Kaggal Department of Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA

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Geoffrey B Thompson Department of Surgery, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA

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thyroidectomy; PTC, papillary thyroid carcinoma; RNM, regional nodal metastases; RRA, radioiodine remnant ablation; Categorical variables are presented as number (%); a Kruskal–Wallis test P -value; b Chi-square test P -value. Details of the

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Nianting Ju Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Liying Hou Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Hongjun Song Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Zhongling Qiu Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Yang Wang Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Zhenkui Sun Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Quanyong Luo Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Chentian Shen Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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international literature, including many guidelines ( 6 , 7 , 8 ), as the minimum level of TSH stimulation for radioiodine therapy including thyroid remnant ablation. However, there is no definite evidence yet that TSH level ≥ 30 mU/L is necessary for

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Fabián Pitoia Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina

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Erika Abelleira Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina

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Graciela Cross Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina

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Introduction Remnant ablation is a traditional procedure that is usually performed after total thyroidectomy in patients with differentiated thyroid cancer (DTC) tumors >1 cm in diameter [ 1 , 2 ]. Numerous studies have confirmed that

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Carolina C.P.S. Janovsky Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Rui M.B. Maciel Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Cleber P. Camacho Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Rosalia P. Padovani Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Claudia C. Nakabashi Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Ji H. Yang Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Eduardo Z. Malouf Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Elza S. Ikejiri Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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M. Conceição O.C. Mamone Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Jairo Wagner Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Danielle M. Andreoni Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Rosa Paula M. Biscolla Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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follow-up care [ 2 , 7 , 8 ]. The treatment of differentiated thyroid cancer usually consists of total thyroidectomy (TT) and radioiodine remnant ablation (RRA) [ 4 , 8 ]. The rationale for the use of RRA comprises: remnant ablation, to facilitate the

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Furio Pacini Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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131 I. The aim of postsurgical ablation of the thyroid remnant with RAI is to facilitate the early detection of recurrence based on serum thyroglobulin (Tg) measurement and RAI whole body scan. In addition, RAI ablation may represent an adjuvant

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Beng Khiong Yap The Christie NHS Foundation Trust

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Jarrod Homer Central Manchester NHS Foundation Trust

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Neil Parrott Central Manchester NHS Foundation Trust

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Sean Loughran Central Manchester NHS Foundation Trust

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Brian Murby The Christie NHS Foundation Trust

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Ric Swindell The Christie NHS Foundation Trust

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Ashu Gandhi University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK

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remove the primary tumour and thyroid tissue to facilitate post-operative remnant ablation with radioactive iodine-131 (RAI). The role of RAI is twofold: firstly to ablate the residual normal thyroid remaining after total thyroidectomy, thus facilitating

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Nicholas S. Andresen Department of Radiation Oncology, University of Iowa, Iowa City, Iowa, USA

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John M. Buatti Department of Radiation Oncology, University of Iowa, Iowa City, Iowa, USA

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Hamed H. Tewfik Iowa City Cancer Treatment Center, Iowa City, Iowa, USA

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Nitin A. Pagedar Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA

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Carryn M. Anderson Department of Radiation Oncology, University of Iowa, Iowa City, Iowa, USA

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John M. Watkins Department of Radiation Oncology, University of Iowa, Iowa City, Iowa, USA

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not be indicated [ 7 , 8 ], and recent phase III trials have demonstrated equivalent rates of thyroid remnant ablation with 30 versus 100 mCi doses of RAI [ 9 , 10 ], practice patterns remain highly variable by individual practitioner [ 11 ]. The

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Laura Agate Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Francesca Bianchi Unit of Endocrine and Oncological Nuclear Medicine Therapy, Diagnostic and Imaging Department, University of Pisa, Pisa, Italy

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Federica Brozzi Unit of Endocrine and Oncological Nuclear Medicine Therapy, Diagnostic and Imaging Department, University of Pisa, Pisa, Italy

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Pierina Santini Unit of Endocrine and Oncological Nuclear Medicine Therapy, Diagnostic and Imaging Department, University of Pisa, Pisa, Italy

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Eleonora Molinaro Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Valeria Bottici Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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David Viola Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Loredana Lorusso Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Paolo Vitti Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Rossella Elisei Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Introduction Until a few years ago, the standard therapy of well-differentiated thyroid cancer (DTC) consisted of total or near total thyroidectomy followed by radioiodine (RAI) remnant ablation (RRA) and TSH suppressive levothyroxine (LT4

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Germán A. Jimenez Londoño Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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Ana Maria Garcia Vicente Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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Julia Sastre Marcos Department of Endocrinology, Complejo Hospitalario de Toledo, Toledo, Spain

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Francisco Jose Pena Pardo Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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Mariano Amo-Salas Department of Mathematics, University of Castilla-La Mancha, Ciudad Real, Spain

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Manuel Moreno Caballero Department of Nuclear Medicine, Hospital Universitario Infanta Cristina Badajoz, Badajoz, Spain

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Maria Prado Talavera Rubio  Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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Beatriz Gonzalez Garcia Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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Niletys Dafne Disotuar Ruiz Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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Angel Maria Soriano Castrejón Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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many patients undergo radioiodine remnant ablation (RRA) to eliminate the residual normal thyroid tissue after total thyroidectomy (TT) or near TT (NTT). Previous works [ 3 - 5 ] have shown that a low dose of 131-I is as effective as a high dose for

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F. Cecoli Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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E.M. Ceresola Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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V. Altrinetti Endocrinology and Nuclear Medicine, Galliera Hospital, Genoa

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M. Cabria Endocrinology and Nuclear Medicine, Galliera Hospital, Genoa

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M. Cappagli Endocrine Unit, Sant'Andrea Hospital, La Spezia

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A. Montepagani Endocrine Unit, Sant'Andrea Hospital, La Spezia

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C.M. Cuttica Endocrinology and Nuclear Medicine, Galliera Hospital, Genoa

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U. Filippi Evangelico Internazionale Hospital, Genoa

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D. Saverino Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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M. Raffa Endocrine-Metabolic Center, ASL 1, Imperia, Italy

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M. Caputo Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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F. Minuto Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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M. Giusti Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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M. Bagnasco Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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Practice for the Diagnosis and Management of Thyroid Nodules. Endocr Pract 2010;16:1-43. 10.4158/10024.GL 20497938 22 Lamartina L, Durante C, Filetti S, Cooper DS: Low-risk differentiated thyroid cancer and radioiodine remnant ablation: a systematic

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