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  • Thyroid-binding inhibitory immunoglobulins x
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Hiroyuki Iwaki Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Kenji Ohba Medical Education Center, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Eisaku Okada Department of Community Health and Preventive Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Takeshi Murakoshi Obstetrics and Gynecology, Maternal and Perinatal Care Center, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Yumiko Kashiwabara Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Chiga Hayashi Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Akio Matsushita Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Shigekazu Sasaki Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Takafumi Suda Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Yutaka Oki Department of Metabolism and Endocrinology, Hamamatsu-Kita Hospital, Hamamatsu, Japan

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Rieko Gemma Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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, ophthalmopathy, and/or signs of thyrotoxicosis (e.g., tachycardia), (2) elevated free triiodothyronine (FT3) and/or FT4 levels, (3) suppressed thyroid-stimulating hormone (TSH) level, and (4) a positive thyrotropin receptor-binding inhibitory immunoglobulin (TBII

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000509324
Volume/Issue:
Volume 10: Issue 5
Free access
Tanja Diana Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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Christian Wüster Endocrine Laboratory Prof. Wüster, Mainz, Germany

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Paul D. Olivo Department of Microbiology, Washington University, St. Louis, Missouri, USA

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Angelica Unterrainer Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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Jochem König Endocrine Laboratory Prof. Wüster, Mainz, Germany

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Michael Kanitz Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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Artur Bossowski Department of Pediatrics, Endocrinology, and Diabetology, Medical University of Byalistok, Bialystok, Poland

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Brigitte Decallonne Division of Clinical and Experimental Endocrinology, UZ Leuven, Leuven, Belgium

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George J. Kahaly Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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diagnosis of GD, serum samples were measured for thyroid-binding inhibitory immunoglobulins (TBII) with the Cobas e411 analyzer, Elecsys (Roche Diagnostics, Mannheim, Germany). For the dilution analysis, TBII concentrations were measured with 4 different

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000478522
Volume/Issue:
Volume 6: Issue 5
Free access
George J. Kahaly Johannes Gutenberg University Medical Center, Mainz, Germany

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12 Ponto KA, Kanitz M, Olivo PD, Pitz S, Pfeiffer N, Kahaly GJ: Clinical relevance of thyroid-stimulating immunoglobulins in Graves' ophthalmopathy. Ophthalmology 2011;118:2279-2285. 10.1016/j.ophtha.2011.03.030 21684605 13 Giuliani C

Article Type:
Editorial
DOI:
https://doi.org/10.1159/000375445
Volume/Issue:
Volume 4: Issue 1
Free access
Tanja Diana Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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Paul D. Olivo Department of Molecular Microbiology, Washington University Medical School, St. Louis, Missouri, USA

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Yie-Hwa Chang Mediomics, LLC, St. Louis, Missouri, USA

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Christian Wüster Endocrine Laboratory and Practice Prof. Wüster, Mainz, Germany

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Michael Kanitz Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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George J. Kahaly Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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thyroid-binding inhibitory immunoglobulins (TBII; Cobas e411 analyzer; Roche Diagnostics, Mannheim, Germany) and an enlarged gland with a typical “thyroid storm pattern” on Doppler ultrasound. Dilutions of Forskolin, M22 MAb Bovine TSH, and Patient

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000504509
Volume/Issue:
Volume 9: Issue 2
Free access
Tanja Diana Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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Hans-Peter Holthoff AdvanceCor GmbH, Martinsried, Germany

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Julia Fassbender AdvanceCor GmbH, Martinsried, Germany

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Christian Wüster Endocrine Laboratory and Practice Prof. Wüster, Mainz, Germany

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Michael Kanitz Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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George J. Kahaly Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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Martin Ungerer AdvanceCor GmbH, Martinsried, Germany

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TBAb) profile, levels of TSHR-binding inhibitory immunoglobulins (TBII) and free thyroxine (fT4) serum levels were measured and evaluated in a novel, long-term murine model for human GD using 7 repeated immunizations over 27 weeks with Ad-TSHR. These

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000508790
Volume/Issue:
Volume 9: Issue 1_Suppl
Free access
Naohiro Araki Diagnostic Division, Otsuka Pharmaceutical Co. Ltd., Tokushima, Japan

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Mitsuru Iida Diagnostic Division, Otsuka Pharmaceutical Co. Ltd., Tokushima, Japan

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Nobuyuki Amino Department of Internal Medicine, Kuma Hospital, Kobe, Japan

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Shinji Morita Department of Internal Medicine, Kuma Hospital, Kobe, Japan

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Akane Ide Department of Internal Medicine, Kuma Hospital, Kobe, Japan

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Eijun Nishihara Department of Internal Medicine, Kuma Hospital, Kobe, Japan

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Mitsuru Ito Department of Internal Medicine, Kuma Hospital, Kobe, Japan

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Jun Saito Department of Medicine, Yokohama Rosai Hospital, Yokohama, Japan

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Tetsuo Nishikawa Department of Medicine, Yokohama Rosai Hospital, Yokohama, Japan

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Kiyonori Katsuragi Diagnostic Division, Otsuka Pharmaceutical Co. Ltd., Tokushima, Japan

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Akira Miyauchi Department of Internal Medicine, Kuma Hospital, Kobe, Japan

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Hashimoto's thyroiditis [ 3 ]. The amount of TSHR antibodies can be measured with competitive binding assays, the so-called thyrotropin-binding inhibitory immunoglobulin/TSHR antibodies (TRAb) assay, using either labeled thyroid-stimulating hormone (TSH

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000371740
Volume/Issue:
Volume 4: Issue 1
Open access
Solène Castellnou Hospices Civils de Lyon, Groupement Hospitalier Est, Fédération d’Endocrinologie, Bron, France

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Patricia Bretones Service d’Endocrinologie Pédiatrique, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France

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Juliette Abeillon Hospices Civils de Lyon, Groupement Hospitalier Est, Fédération d’Endocrinologie, Bron, France

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Myriam Moret Hospices Civils de Lyon, Groupement Hospitalier Est, Fédération d’Endocrinologie, Bron, France

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Pauline Perrin Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, Groupement Hospitalier Est, LBMMS, Bron, France

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Karim Chikh Centre de Biologie et de Pathologie Sud, Hospices Civils de Lyon, Groupement Hospitalier Sud, LBMMS, Saint Genis Laval, France

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Véronique Raverot Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, Groupement Hospitalier Est, LBMMS, Bron, France

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): 76 – 94 . 10.1159/000362597 25114871 2235-0640 24 Abeillon-du Payrat J , Chikh K , Bossard N , Bretones P , Gaucherand P , Claris O , et al. Predictive value of maternal second-generation thyroid-binding inhibitory

Article Type:
Case Report
Collections:
Hypothyroidism
DOI:
https://doi.org/10.1159/000509015
Volume/Issue:
Volume 10: Issue 2
Free access
Anke Schlüter Molecular Ophthalmology, Department of Ophthalmology, University Hospital Essen, Essen, Germany
Department of Oto-Rhino-Laryngology – Head and Neck Surgery, University Hospital Essen, Essen, Germany

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Anja K. Eckstein Molecular Ophthalmology, Department of Ophthalmology, University Hospital Essen, Essen, Germany
Department of Ophthalmology, University Hospital Essen, Essen, Germany

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Alexandra Brenzel Imaging Center Essen (IMCES), Institute for Experimental Immunology and Imaging, University Hospital Essen, Essen, Germany

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Mareike Horstmann Molecular Ophthalmology, Department of Ophthalmology, University Hospital Essen, Essen, Germany

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Stephan Lang Department of Oto-Rhino-Laryngology – Head and Neck Surgery, University Hospital Essen, Essen, Germany

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Utta Berchner-Pfannschmidt Molecular Ophthalmology, Department of Ophthalmology, University Hospital Essen, Essen, Germany

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J. Paul Banga Molecular Ophthalmology, Department of Ophthalmology, University Hospital Essen, Essen, Germany

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Salvador Diaz-Cano Department of Histopathology, King’s College Hospital NHS, London, United Kingdom

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A; for all online suppl. material, see online Supplementary Materials). Evaluation of serum for anti-TSHR antibodies showed all TSHR-immunized animals to be positive for TSH binding inhibitory immunoglobulins, while none of the control animals were

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000488079
Volume/Issue:
Volume 7: Issue 3
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Ola Lindgren Department of Endocrinology, Lund University, Malmö, Sweden
Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden

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Pernilla Asp Department of Oncology, Skåne University Hospital, Lund, Sweden

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Anna Sundlöv Department of Oncology, Lund University, and Department of Clinical Sciences, Skåne University Hospital, Lund, Sweden

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Jan Tennvall Department of Oncology, Lund University, and Department of Clinical Sciences, Skåne University Hospital, Lund, Sweden

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Bushra Shahida Department of Clinical Sciences Malmö, and Diabetes and Endocrinology, Lund University, Malmö, Sweden

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Tereza Planck Department of Endocrinology, Lund University, Malmö, Sweden
Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden

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Peter Åsman Department of Clinical Sciences Malmö, Ophthalmology, Lund University, and Department of Ophthalmology, Skåne University Hospital, Malmö, Sweden

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Mikael Lantz Department of Endocrinology, Lund University, Malmö, Sweden
Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden

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Teng CS , Yeung RT , Khoo RK , Alagaratnam TT . A prospective study of the changes in thyrotropin binding inhibitory immunoglobulins in Graves’ disease treated by subtotal thyroidectomy or radioactive iodine . J Clin Endocrinol Metab . 1980

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000495504
Volume/Issue:
Volume 8: Issue 2
Free access
Susanne Neumann Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda, Bethesda, Maryland, USA

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Christine C. Krieger Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda, Bethesda, Maryland, USA

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Marvin C. Gershengorn Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda, Bethesda, Maryland, USA

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TSH/IGF-1 Receptor Crosstalk in Graves’ Orbital Fibroblasts in Primary Culture The discovery of thyroid-stimulating hormone receptor (TSHR) expression in orbital fat tissue and extra-ocular muscles [ 1 ] suggested that TSHR is one of the

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000511538
Volume/Issue:
Volume 9: Issue 1_Suppl
Free access