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  • Thyrotropin receptor x
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Tanja Diana Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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Hans-Peter Holthoff AdvanceCor GmbH, Martinsried, Germany

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Julia Fassbender AdvanceCor GmbH, Martinsried, Germany

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Christian Wüster Endocrine Laboratory and Practice Prof. Wüster, Mainz, Germany

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Michael Kanitz Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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George J. Kahaly Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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Martin Ungerer AdvanceCor GmbH, Martinsried, Germany

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mice were also studied. Free Thyroxine Levels and Thyrotropin Receptor Antibodies Serum fT4 and TSHR-binding inhibiting autoantibodies (TBII) levels were measured with Immulite 2000 XPi (Siemens, Erlangen, Germany) according to the

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000508790
Volume/Issue:
Volume 9: Issue 1_Suppl
Free access
Tanja Diana Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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Paul D. Olivo Department of Molecular Microbiology, Washington University Medical School, St. Louis, Missouri, USA

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Yie-Hwa Chang Mediomics, LLC, St. Louis, Missouri, USA

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Christian Wüster Endocrine Laboratory and Practice Prof. Wüster, Mainz, Germany

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Michael Kanitz Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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George J. Kahaly Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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Introduction Autoantibodies against the thyrotropin receptor (TSH-R-Ab) play an important role in the pathogenesis of autoimmune thyroid diseases [ 1 - 5 ]. These functional antibodies demonstrate different effects on the TSH-R and can either

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000504509
Volume/Issue:
Volume 9: Issue 2
Free access
Lars Folkestad Department of Endocrinology, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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Frans Brandt Department of Internal Medicine, Hospital of Southern Jutland, Sønderborg, Denmark

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Thomas Brix Department of Endocrinology, Odense University Hospital, Odense, Denmark

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Marianne Vogsen Department of Oncology, Odense University Hospital, Odense, Denmark

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Lars Bastholt Department of Oncology, Odense University Hospital, Odense, Denmark

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Peter Grupe Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark

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Jeanette  Krogh Petersen Department of Clinical Pathology, Odense University Hospital, Odense, Denmark

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Laszlo Hegedüs Department of Endocrinology, Odense University Hospital, Odense, Denmark

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What Is Known about This Topic? The prevalence of thyrotoxicosis in patients with thyroid cancer is unknown. In view of the sparse reports, it is most likely very low. Thyrotropin receptor antibodies are seldom measured or found in

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000479061
Volume/Issue:
Volume 6: Issue 5
Free access
Solène Castellnou Hospices Civils de Lyon, Groupement Hospitalier Est, Fédération d’Endocrinologie, Bron, France

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Patricia Bretones Service d’Endocrinologie Pédiatrique, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France

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Juliette Abeillon Hospices Civils de Lyon, Groupement Hospitalier Est, Fédération d’Endocrinologie, Bron, France

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Myriam Moret Hospices Civils de Lyon, Groupement Hospitalier Est, Fédération d’Endocrinologie, Bron, France

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Pauline Perrin Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, Groupement Hospitalier Est, LBMMS, Bron, France

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Karim Chikh Centre de Biologie et de Pathologie Sud, Hospices Civils de Lyon, Groupement Hospitalier Sud, LBMMS, Saint Genis Laval, France

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Véronique Raverot Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, Groupement Hospitalier Est, LBMMS, Bron, France

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-9972 2 Diana T , Olivo PD , Kahaly GJ . Thyrotropin Receptor Blocking Antibodies . Horm Metab Res . 2018 Dec ; 50 ( 12 ): 853 – 62 . 10.1055/a-0723-9023 30286485 0018-5043 3 Kanike N , Davis A , Shekhawat PS

Article Type:
Case Report
Collections:
Hypothyroidism
DOI:
https://doi.org/10.1159/000509015
Volume/Issue:
Volume 10: Issue 2
Free access
J. Lüblinghoff Department of Endocrinology and Nephrology, Leipzig University, Leipzig, Germany

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I.T. Nebel Department of Endocrinology and Nephrology, Leipzig University, Leipzig, Germany

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S. Huth Department of Endocrinology and Nephrology, Leipzig University, Leipzig, Germany

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H. Jäschke Department of Endocrinology and Nephrology, Leipzig University, Leipzig, Germany

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J. Schaarschmidt Department of Endocrinology and Nephrology, Leipzig University, Leipzig, Germany

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M. Eszlinger Department of Endocrinology and Nephrology, Leipzig University, Leipzig, Germany

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R. Paschke Department of Endocrinology and Nephrology, Leipzig University, Leipzig, Germany

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Article Type:
Letter
DOI:
https://doi.org/10.1159/000342918
Volume/Issue:
Volume 1: Issue 3
Free access
Tanvir Rizvi Nuclear Medicine Division, Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Va., USA

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Patrice K. Rehm Nuclear Medicine Division, Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Va., USA

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to promiscuous activation of the thyrotropin receptor by chorionic gonadotropin [ 21 ]. Follicle-stimulating hormone (FSH), luteinizing hormone, chorionic gonadotropin and TSH constitute the glycoprotein hormones made of a common α-subunit and

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000360852
Volume/Issue:
Volume 3: Issue 2
Free access
Alan Chun Hong Lee Division of Endocrinology and Metabolism, Department of Medicine, Queen Mary Hospital, Hong Kong, China
Department of Medicine I, Johannes Gutenberg University Medical Center, Mainz, Germany

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George J. Kahaly Department of Medicine I, Johannes Gutenberg University Medical Center, Mainz, Germany

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mechanisms. Although the levels of thyrotropin receptor autoantibody (TSH-R-Ab), which is the specific biomarker of GD [ 11 , 12 ], decline during ATD therapy, ATDs primarily inhibit thyroid hormone biosynthesis only, and whether they directly target thyroid

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000508789
Volume/Issue:
Volume 9: Issue 1_Suppl
Free access
Gerd Krause Structural Biology, Leibniz-Forschungsinstitut für molekulare Pharmakologie (FMP), Berlin, Germany

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Anja Eckstein Department of Ophthalmology, University Hospital Essen, Essen, Germany

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Ralf Schülein Protein Trafficking, Leibniz-Forschungsinstitut für molekulare Pharmakologie (FMP), Berlin, Germany

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Introduction TSH-Receptor, Graves’ Disease and Graves’ Orbitopathy The thyrotropin receptor or thyroid-stimulating hormone (TSH) receptor (TSHR) is mainly expressed in follicular epithelial cells of the thyroid gland [ 1 ]. TSHR activation

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000511871
Volume/Issue:
Volume 9: Issue 1_Suppl
Free access
Emilie Brûlé Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada

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Xiang Zhou Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada

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Ying Wang Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada

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Evan R S Buddle Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada

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Luisina Ongaro Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada

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Mary Loka Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada

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Anita Boelen Endocrine Laboratory, Department of Laboratory Medicine, University of Amsterdam, Amsterdam Gastroenterology, Endocrinology & Metabolism Research Institute, Amsterdam, The Netherlands

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Daniel J Bernard Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada

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genes generally lead to milder forms of the disease. TSH secretion is regulated by thyrotropin-releasing hormone (TRH) from the paraventricular nucleus (PVN) of the hypothalamus, which acts on the TRH receptor (TRHR) on pituitary thyrotropes

Article Type:
Research Article
Collections:
Hypothalamus-pituitary-thyroid axis
DOI:
https://doi.org/10.1530/ETJ-23-0054
Volume/Issue:
Volume 13: Issue 1
Open access
Ringo Manta Department of Nuclear Medicine, CHU Saint Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Charlotte Martin Department of Infectious Diseases, CHU Saint Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Vinciane Muls Department of Gastroenterology and Endoscopy, CHU Saint-Pierre, University Libre de Bruxelles (ULB), Brussels, Belgium

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Kris G Poppe Department of Endocrinology, CHU Saint Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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vedolizumab, oral budesonide and mycophenolic acid. In April 2020, the patient presented a mild COVID-19 and received hydroxychloroquine. Concomitantly, he developed transient hypothyroidism with negative thyroid peroxidase antibody (TPOAb) and thyrotropin-receptor

Article Type:
Case Report
Collections:
Hyperthyroidism and thyrotoxicosis
DOI:
https://doi.org/10.1530/ETJ-22-0049
Volume/Issue:
Volume 11: Issue 4
Open access