Lars C. Moeller
Lars C. Moeller
Department of Endocrinology and Metabolism, University of Duisburg-Essen, Essen, Germany
Search for other papers by Lars C. Moeller in
Google Scholar
PubMed
Search for other papers by Lars C. Moeller in
Google Scholar
PubMed
Yaw Appiagyei-Dankah
Yaw Appiagyei-Dankah
Medical University of South Carolina, Charleston, S.C., USA
Search for other papers by Yaw Appiagyei-Dankah in
Google Scholar
PubMed
Search for other papers by Yaw Appiagyei-Dankah in
Google Scholar
PubMed
Birgit Köhler
Birgit Köhler
Institut für Experimentelle Pädiatrische Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany
Search for other papers by Birgit Köhler in
Google Scholar
PubMed
Search for other papers by Birgit Köhler in
Google Scholar
PubMed
Heike Biebermann
Heike Biebermann
Institut für Experimentelle Pädiatrische Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany
Search for other papers by Heike Biebermann in
Google Scholar
PubMed
Search for other papers by Heike Biebermann in
Google Scholar
PubMed
Onno E. Janssen
Onno E. Janssen
Department of Endocrinology and Metabolism, University of Duisburg-Essen, Essen, Germany
Search for other papers by Onno E. Janssen in
Google Scholar
PubMed
Search for other papers by Onno E. Janssen in
Google Scholar
PubMed
Dagmar Führer
Dagmar Führer
Department of Endocrinology and Metabolism, University of Duisburg-Essen, Essen, Germany
Search for other papers by Dagmar Führer in
Google Scholar
PubMed
Search for other papers by Dagmar Führer in
Google Scholar
PubMed
Introduction In serum, thyroid hormone (TH) is mainly bound to transport proteins. The major proportion of circulating TH, 75% of T 4 and 70% of T 3 is bound to thyroxine-binding globulin [TBG; HUGO Gene Nomenclature Committee approved name
Theodora Pappa
Theodora Pappa
Departments of Medicine, Chicago, IL, USA
Search for other papers by Theodora Pappa in
Google Scholar
PubMed
Search for other papers by Theodora Pappa in
Google Scholar
PubMed
Lars C. Moeller
Lars C. Moeller
Department of Endocrinology and Division of Laboratory Research, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Search for other papers by Lars C. Moeller in
Google Scholar
PubMed
Search for other papers by Lars C. Moeller in
Google Scholar
PubMed
Deborah V. Edidin
Deborah V. Edidin
Department of Pediatrics, Feinberg School of Medicine Northwestern University, Chicago, IL, USA
Search for other papers by Deborah V. Edidin in
Google Scholar
PubMed
Search for other papers by Deborah V. Edidin in
Google Scholar
PubMed
Silvana Pannain
Silvana Pannain
Departments of Medicine, Chicago, IL, USA
Search for other papers by Silvana Pannain in
Google Scholar
PubMed
Search for other papers by Silvana Pannain in
Google Scholar
PubMed
Samuel Refetoff
Samuel Refetoff
Departments of Medicine, Chicago, IL, USA
Departments of Pediatrics, Chicago, IL, USA
Departments of Committee on Genetics, The University of Chicago, Chicago, IL, USA
Search for other papers by Samuel Refetoff in
Google Scholar
PubMed
Departments of Pediatrics, Chicago, IL, USA
Departments of Committee on Genetics, The University of Chicago, Chicago, IL, USA
Search for other papers by Samuel Refetoff in
Google Scholar
PubMed
What Is Known about This Topic? • Partial thyroxine-binding globulin deficiency (TBG-PD) is an X-linked inherited TBG defect, which produces alterations in thyroid function tests, but no metabolic abnormality. • Clinical awareness is needed
Kevin Stroek
Kevin Stroek
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
Search for other papers by Kevin Stroek in
Google Scholar
PubMed
Search for other papers by Kevin Stroek in
Google Scholar
PubMed
Annemieke C. Heijboer
Annemieke C. Heijboer
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands
Search for other papers by Annemieke C. Heijboer in
Google Scholar
PubMed
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands
Search for other papers by Annemieke C. Heijboer in
Google Scholar
PubMed
Marja van Veen-Sijne
Marja van Veen-Sijne
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
Search for other papers by Marja van Veen-Sijne in
Google Scholar
PubMed
Search for other papers by Marja van Veen-Sijne in
Google Scholar
PubMed
Annet M. Bosch
Annet M. Bosch
Division of Metabolic Disorders, Department of Pediatrics, Emma Children’s Hospital, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
Search for other papers by Annet M. Bosch in
Google Scholar
PubMed
Search for other papers by Annet M. Bosch in
Google Scholar
PubMed
Catharina P.B. van der Ploeg
Catharina P.B. van der Ploeg
Department of Child Health, Netherlands Organization for Applied Scientific Research TNO, Leiden, The Netherlands
Search for other papers by Catharina P.B. van der Ploeg in
Google Scholar
PubMed
Search for other papers by Catharina P.B. van der Ploeg in
Google Scholar
PubMed
Nitash Zwaveling-Soonawala
Nitash Zwaveling-Soonawala
Department of Paediatric Endocrinology, Emma Children’s Hospital, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
Search for other papers by Nitash Zwaveling-Soonawala in
Google Scholar
PubMed
Search for other papers by Nitash Zwaveling-Soonawala in
Google Scholar
PubMed
Robert de Jonge
Robert de Jonge
Department of Clinical Chemistry, Amsterdam UMC, Vrije Universiteit & University of Amsterdam, Amsterdam, The Netherlands
Search for other papers by Robert de Jonge in
Google Scholar
PubMed
Search for other papers by Robert de Jonge in
Google Scholar
PubMed
A.S. Paul van Trotsenburg
A.S. Paul van Trotsenburg
Department of Paediatric Endocrinology, Emma Children’s Hospital, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
Search for other papers by A.S. Paul van Trotsenburg in
Google Scholar
PubMed
Search for other papers by A.S. Paul van Trotsenburg in
Google Scholar
PubMed
Anita Boelen
Anita Boelen
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
Search for other papers by Anita Boelen in
Google Scholar
PubMed
Search for other papers by Anita Boelen in
Google Scholar
PubMed
concentrations, and in order to detect CH-C, thyroxine-binding globulin (TBG) is measured in the lowest 5% of T4 concentrations enabling calculation of a modified T4/TBG ratio that serves as an indirect measure of free T4 (FT4). With this approach, low T4 values
Heleen I Jansen
Heleen I Jansen
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Search for other papers by Heleen I Jansen in
Google Scholar
PubMed
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Search for other papers by Heleen I Jansen in
Google Scholar
PubMed
Antonius E van Herwaarden
Antonius E van Herwaarden
Radboud University Medical Center, Department of Laboratory Medicine, Nijmegen, The Netherlands
Search for other papers by Antonius E van Herwaarden in
Google Scholar
PubMed
Search for other papers by Antonius E van Herwaarden in
Google Scholar
PubMed
Henk J Huijgen
Henk J Huijgen
Department of Clinical Chemistry, Red Cross Hospital, Beverwijk, The Netherlands
Search for other papers by Henk J Huijgen in
Google Scholar
PubMed
Search for other papers by Henk J Huijgen in
Google Scholar
PubMed
Rebecca C Painter
Rebecca C Painter
Department of Obstetrics and Gynaecology, Amsterdam UMC Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Search for other papers by Rebecca C Painter in
Google Scholar
PubMed
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Search for other papers by Rebecca C Painter in
Google Scholar
PubMed
Jacquelien J Hillebrand
Jacquelien J Hillebrand
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Search for other papers by Jacquelien J Hillebrand in
Google Scholar
PubMed
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Search for other papers by Jacquelien J Hillebrand in
Google Scholar
PubMed
Anita Boelen
Anita Boelen
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Search for other papers by Anita Boelen in
Google Scholar
PubMed
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Search for other papers by Anita Boelen in
Google Scholar
PubMed
Annemieke C Heijboer
Annemieke C Heijboer
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Search for other papers by Annemieke C Heijboer in
Google Scholar
PubMed
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Search for other papers by Annemieke C Heijboer in
Google Scholar
PubMed
illness. II. Effect of prealbumin, albumin, and thyroxin-binding globulin . Clinical Chemistry 1989 35 1655 – 1662 . ( https://doi.org/10.1093/clinchem/35.8.1655 ) 35 Bayer MF Free thyroxine results are affected by albumin concentration and
Anita Boelen
Anita Boelen
Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Search for other papers by Anita Boelen in
Google Scholar
PubMed
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Search for other papers by Anita Boelen in
Google Scholar
PubMed
Nitash Zwaveling-Soonawala
Nitash Zwaveling-Soonawala
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands
Search for other papers by Nitash Zwaveling-Soonawala in
Google Scholar
PubMed
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands
Search for other papers by Nitash Zwaveling-Soonawala in
Google Scholar
PubMed
Annemieke C Heijboer
Annemieke C Heijboer
Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Search for other papers by Annemieke C Heijboer in
Google Scholar
PubMed
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Search for other papers by Annemieke C Heijboer in
Google Scholar
PubMed
A S Paul van Trotsenburg
A S Paul van Trotsenburg
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands
Search for other papers by A S Paul van Trotsenburg in
Google Scholar
PubMed
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands
Search for other papers by A S Paul van Trotsenburg in
Google Scholar
PubMed
in detecting central CH as low blood T4 concentrations are also found in premature and sick neonates, and in thyroxine-binding globulin (TBG) deficiency, a harmless condition resulting in a high number of false-positive NBS results. With the advent of
Françoise Brucker-Davis
Françoise Brucker-Davis
Department of Endocrinology, Diabetology and Reproductive Medicine
Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France
Search for other papers by Françoise Brucker-Davis in
Google Scholar
PubMed
Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France
Search for other papers by Françoise Brucker-Davis in
Google Scholar
PubMed
Patricia Panaïa-Ferrari
Patricia Panaïa-Ferrari
Departments of Biochemistry, UMR U895, Université Nice-Sophia Antipolis, Nice, France
Search for other papers by Patricia Panaïa-Ferrari in
Google Scholar
PubMed
Search for other papers by Patricia Panaïa-Ferrari in
Google Scholar
PubMed
Jocelyn Gal
Jocelyn Gal
Departments of Biostatistics, CHU de Nice, UMR U895, Université Nice-Sophia Antipolis, Nice, France
Search for other papers by Jocelyn Gal in
Google Scholar
PubMed
Search for other papers by Jocelyn Gal in
Google Scholar
PubMed
Patrick Fénichel
Patrick Fénichel
Department of Endocrinology, Diabetology and Reproductive Medicine
Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France
Search for other papers by Patrick Fénichel in
Google Scholar
PubMed
Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France
Search for other papers by Patrick Fénichel in
Google Scholar
PubMed
Sylvie Hiéronimus
Sylvie Hiéronimus
Department of Endocrinology, Diabetology and Reproductive Medicine
Search for other papers by Sylvie Hiéronimus in
Google Scholar
PubMed
Search for other papers by Sylvie Hiéronimus in
Google Scholar
PubMed
increased estradiol production (causing a rise in thyroxine-binding globulin - TBG), and the changes in iodine renal clearance and needs. Those changes result in a gradual increase in thyroid hormone production contrasting with a reported drop in free T4 (FT
Salvatore Benvenga
Salvatore Benvenga
Department of Clinical and Experimental Medicine, Italy
Master Program on Childhood, Adolescent and Women's Endocrine Health, University of Messina School of Medicine, Italy
Interdepartmental Program of Molecular and Clinical Endocrinology, and Women's Endocrine Health, University Hospital Policlinico G. Martino, Messina, Italy
Search for other papers by Salvatore Benvenga in
Google Scholar
PubMed
Master Program on Childhood, Adolescent and Women's Endocrine Health, University of Messina School of Medicine, Italy
Interdepartmental Program of Molecular and Clinical Endocrinology, and Women's Endocrine Health, University Hospital Policlinico G. Martino, Messina, Italy
Search for other papers by Salvatore Benvenga in
Google Scholar
PubMed
Roberto Vita
Roberto Vita
Department of Clinical and Experimental Medicine, Italy
Search for other papers by Roberto Vita in
Google Scholar
PubMed
Search for other papers by Roberto Vita in
Google Scholar
PubMed
Flavia Di Bari
Flavia Di Bari
Department of Clinical and Experimental Medicine, Italy
Search for other papers by Flavia Di Bari in
Google Scholar
PubMed
Search for other papers by Flavia Di Bari in
Google Scholar
PubMed
Poupak Fallahi
Poupak Fallahi
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Search for other papers by Poupak Fallahi in
Google Scholar
PubMed
Search for other papers by Poupak Fallahi in
Google Scholar
PubMed
Alessandro Antonelli
Alessandro Antonelli
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Search for other papers by Alessandro Antonelli in
Google Scholar
PubMed
Search for other papers by Alessandro Antonelli in
Google Scholar
PubMed
thyroxine requirements due to binding of T4 to the excreted albumin') and two references [ 7 , 8 ]. Another article [ 4 ] devotes 12 lines and 9 references to nephrotic syndrome, plus a mention in two tables. The very recently released American guidelines
Theodora Pappa
Theodora Pappa
Endocrine Unit, Department of Clinical Therapeutics, Alexandra Hospital
Search for other papers by Theodora Pappa in
Google Scholar
PubMed
Search for other papers by Theodora Pappa in
Google Scholar
PubMed
Maria Alevizaki
Maria Alevizaki
Endocrine Unit, Department of Clinical Therapeutics, Alexandra Hospital
Department of Endocrinology, Metabolism and Diabetes, Evgenideion Hospital, Athens University School of Medicine, Athens, Greece
Search for other papers by Maria Alevizaki in
Google Scholar
PubMed
Department of Endocrinology, Metabolism and Diabetes, Evgenideion Hospital, Athens University School of Medicine, Athens, Greece
Search for other papers by Maria Alevizaki in
Google Scholar
PubMed
action, i.e. increased heart rate and basal metabolic rate, as well as sex hormone binding globulin level. Given the ability of metformin to cross the blood-brain barrier and its high concentration in the pituitary, it was hypothesized that metformin may
Heleen I Jansen
Heleen I Jansen
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC location Vrije Universiteit Amsterdam, Boelelaan, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Search for other papers by Heleen I Jansen in
Google Scholar
PubMed
Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Search for other papers by Heleen I Jansen in
Google Scholar
PubMed
Marije van Haeringen
Marije van Haeringen
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Department of Computer Science, Vrije Universiteit, Boelelaan, Amsterdam, The Netherlands
Search for other papers by Marije van Haeringen in
Google Scholar
PubMed
Department of Computer Science, Vrije Universiteit, Boelelaan, Amsterdam, The Netherlands
Search for other papers by Marije van Haeringen in
Google Scholar
PubMed
Marelle J Bouva
Marelle J Bouva
Reference Laboratory Neonatal Screening, Center for Health protection, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Search for other papers by Marelle J Bouva in
Google Scholar
PubMed
Search for other papers by Marelle J Bouva in
Google Scholar
PubMed
Wendy P J den Elzen
Wendy P J den Elzen
Department of Laboratory Medicine, Laboratory Specialized Diagnostics & Research, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Public Health, Amsterdam, The Netherlands
Search for other papers by Wendy P J den Elzen in
Google Scholar
PubMed
Amsterdam Public Health, Amsterdam, The Netherlands
Search for other papers by Wendy P J den Elzen in
Google Scholar
PubMed
Eveline Bruinstroop
Eveline Bruinstroop
Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Endocrinology and Metabolism, Amsterdam UMC location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Search for other papers by Eveline Bruinstroop in
Google Scholar
PubMed
Department of Endocrinology and Metabolism, Amsterdam UMC location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Search for other papers by Eveline Bruinstroop in
Google Scholar
PubMed
Catharina P B van der Ploeg
Catharina P B van der Ploeg
TNO - Child Health, Sylviusweg, Leiden, The Netherlands
Search for other papers by Catharina P B van der Ploeg in
Google Scholar
PubMed
Search for other papers by Catharina P B van der Ploeg in
Google Scholar
PubMed
A S Paul van Trotsenburg
A S Paul van Trotsenburg
Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Paediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Search for other papers by A S Paul van Trotsenburg in
Google Scholar
PubMed
Department of Paediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Search for other papers by A S Paul van Trotsenburg in
Google Scholar
PubMed
Nitash Zwaveling-Soonawala
Nitash Zwaveling-Soonawala
Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Paediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Search for other papers by Nitash Zwaveling-Soonawala in
Google Scholar
PubMed
Department of Paediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Search for other papers by Nitash Zwaveling-Soonawala in
Google Scholar
PubMed
Annemieke C Heijboer
Annemieke C Heijboer
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC location Vrije Universiteit Amsterdam, Boelelaan, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Search for other papers by Annemieke C Heijboer in
Google Scholar
PubMed
Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Search for other papers by Annemieke C Heijboer in
Google Scholar
PubMed
Annet M Bosch
Annet M Bosch
Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Pediatrics, Division of Metabolic Disorders, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Search for other papers by Annet M Bosch in
Google Scholar
PubMed
Department of Pediatrics, Division of Metabolic Disorders, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Search for other papers by Annet M Bosch in
Google Scholar
PubMed
Robert de Jonge
Robert de Jonge
Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Laboratory Medicine, Amsterdam UMC, Vrije Universiteit, Boelelaan, Amsterdam, The Netherlands
Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Search for other papers by Robert de Jonge in
Google Scholar
PubMed
Department of Laboratory Medicine, Amsterdam UMC, Vrije Universiteit, Boelelaan, Amsterdam, The Netherlands
Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Search for other papers by Robert de Jonge in
Google Scholar
PubMed
Mark Hoogendoorn
Mark Hoogendoorn
Department of Computer Science, Vrije Universiteit, Boelelaan, Amsterdam, The Netherlands
Search for other papers by Mark Hoogendoorn in
Google Scholar
PubMed
Search for other papers by Mark Hoogendoorn in
Google Scholar
PubMed
Anita Boelen
Anita Boelen
Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Search for other papers by Anita Boelen in
Google Scholar
PubMed
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Search for other papers by Anita Boelen in
Google Scholar
PubMed
deviation from the daily mean (T4_SD). In case of a T4_SD ≤ −0.8, TSH is measured (approximately the lowest 20% of the daily mean) and in case of a T4_SD ≤ −1.6, thyroxine binding globulin (TBG) is measured as well (approximately the lowest 5% of the daily T
Ulrich Schweizer
Ulrich Schweizer
Institut für Biochemie und Molekularbiologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany
Search for other papers by Ulrich Schweizer in
Google Scholar
PubMed
Search for other papers by Ulrich Schweizer in
Google Scholar
PubMed
Jörg Johannes
Jörg Johannes
Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany
Search for other papers by Jörg Johannes in
Google Scholar
PubMed
Search for other papers by Jörg Johannes in
Google Scholar
PubMed
Dorothea Bayer
Dorothea Bayer
Institut für Biochemie und Molekularbiologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany
Search for other papers by Dorothea Bayer in
Google Scholar
PubMed
Search for other papers by Dorothea Bayer in
Google Scholar
PubMed
Doreen Braun
Doreen Braun
Institut für Biochemie und Molekularbiologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany
Search for other papers by Doreen Braun in
Google Scholar
PubMed
Search for other papers by Doreen Braun in
Google Scholar
PubMed
mutations on T 4 binding, the authors suggested that only Tr1 represents a physiological T 4 -binding site [ 32 ]. More recently the structure of TH-binding globulin in complex with T 4 was reported [ 37 ]. The T 4 -binding site is found on the surface
