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the first 12 weeks following anti-CTLA-4 therapy. In this case, Graves disease developed after 8 years of tremelimumab therapy for metastatic melanoma. Antithyroid drug therapy was safe and effective alongside anti-CTLA-4 therapy without
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Multidisciplinary Thyroid Eye Consultation, Department of Endocrinology, Larrey University Hospital, Toulouse, France
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. Anti-cytotoxic T-lymphocytic-associated antigen-4 antibodies (ipilimumab, tremelimumab) preferentially exhibited pituitary toxicity with hypophysitis as the primary consequence. The most frequent endocrine disorders related to anti-PD-1 monoclonal
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Treatment of Ipilimumab Induced Graves ’ Disease in a Patient with Metastatic Melanoma. 2016 ;2016(Table 1):1–5. 12 Gan EH , Mitchell AL , Plummer R , Pearce S , Perros P . Tremelimumab-Induced Graves Hyperthyroidism. 2017 ;167