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Salman Razvi Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK
Department of Endocrinology, Gateshead Health NHS Foundation Trust, Gateshead, UK

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Avais Jabbar Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK
Department of Cardiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

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Arjola Bano Department of Cardiology, Institute of Social and Preventive Medicine, University of Bern, Bern University Hospital, Bern, Switzerland

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Lorna Ingoe Department of Endocrinology, Gateshead Health NHS Foundation Trust, Gateshead, UK

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Peter Carey Departments of Endocrinology and Cardiology, South Tyneside and Sunderland NHS Foundation Trust, Sunderland, UK

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Shahid Junejo Departments of Endocrinology and Cardiology, South Tyneside and Sunderland NHS Foundation Trust, Sunderland, UK

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Honey Thomas Department of Cardiology, Northumbria Healthcare NHS Foundation Trust, Cramlington, UK

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Caroline Addison Department of Biochemistry, Gateshead Health NHS Foundation Trust, Gateshead, UK

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David Austin Department of Cardiology, South Tees Health NHS Foundation Trust, Middlesbrough, UK

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John P Greenwood Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK

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Azfar G Zaman Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK
Department of Cardiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

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Introduction Cardiovascular diseases including acute myocardial infarction (AMI) are one of the leading causes of morbidity and mortality globally. Despite the improvements in patient outcomes, morbidity and mortality in AMI patients remain

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Matthew J. Brooks Departments of Cardiology, The Royal Melbourne Hospital, Melbourne, Vic., Australia

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David A. Pattison Departments of Endocrinology, The Royal Melbourne Hospital, Melbourne, Vic., Australia

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Eliza P. Teo Departments of Cardiology, The Royal Melbourne Hospital, Melbourne, Vic., Australia

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Sarah Price Departments of Endocrinology, The Royal Melbourne Hospital, Melbourne, Vic., Australia

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Ronen Gurvitch Departments of Cardiology, The Royal Melbourne Hospital, Melbourne, Vic., Australia

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;18:273-276. 10.1089/thy.2007.0131 18279027 7 Lewandowski KC, Rechcinski T, Krzeminska-Pakula M, Lewinski A: Acute myocardial infarction as the first presentation of thyrotoxicosis in a 31-year-old woman - case report. Thyroid Res 2010;3:1. 10

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Natsuko Watanabe Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Jaeduk Yoshimura Noh Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Naomi Hattori Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Kenji Iwaku Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Nami Suzuki Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Ai Yoshihara Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Hidemi Ohye Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Miho Suzuki Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Masako Matsumoto Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Kei Endo Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Yo Kunii Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Gen Takagi Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan

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Kiminori Sugino Department of Surgery, Ito Hospital, Tokyo, Japan

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Koichi Ito Department of Surgery, Ito Hospital, Tokyo, Japan

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.1097/00019501-200505000-00001 5 Kim HJ , Jung TS , Hahm JR , Hwang SJ , Lee SM , Jung JH , . Thyrotoxicosis-induced acute myocardial infarction due to painless thyroiditis . Thyroid . 2011 ; 21 ( 10 ): 1149 – 51 . http://dx.doi.org/10.1089/thy.2010

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Hiroki Kobayashi Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan

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Akira Haketa Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan

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Masanori Abe Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan

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Kazunobu Tahira Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan

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Yoshinari Hatanaka Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan

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Sho Tanaka Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan

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Takahiro Ueno Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan

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Masayoshi Soma Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan

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presence of acute myocardial damage. She underwent implantable cardioverter defibrillator placement 1 month after admission for secondary prevention. Her condition stabilized with no emergent symptoms and she was discharged on day 43. No signs of

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Rob Janssen Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands

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Alice Muller Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands

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Warner S. Simonides Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands

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after acute myocardial infarction: possible implications in cardiac remodelling. Eur J Endocrinol 2007;156: 415–424. 10.1530/EJE-06-0707 17389455 43 Belke DD, Gloss B, Swanson EA, Dillmann WH: Adeno-associated virus-mediated expression of thyroid

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Luisa Paschke Department of Endocrinology and Nephrology, Division of Endocrinology, University Clinic Leipzig, Leipzig, Germany
Department of Endocrinology and Nephrology, Division of Nephrology, University Clinic Leipzig, Leipzig, Germany

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Thomas Lincke Department of Radiology, Division of Nuclear Medicine, University Clinic Leipzig, Leipzig, Germany

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Katja Sibylle Mühlberg Department of Angiology, University Clinic Leipzig, Leipzig, Germany

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Wolfram J. Jabs Department of Nephrology, Vivantes Clinics, Berlin, Germany

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Tom H. Lindner Department of Endocrinology and Nephrology, Division of Nephrology, University Clinic Leipzig, Leipzig, Germany

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Ralf Paschke Division of Endocrinology, University of Calgary, Calgary, Alberta, Canada

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coronary heart disease with myocardial infarction 8 years before study inclusion. He presented a KDOQI stage 2 prior to the study introduction with an eGFR of 71.09 mL/min/1.73 m 2 . There was spurious proteinuria assessed by a urine dip stix at study entry

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Camille Buffet Department of Thyroid Pathologies and Endocrine Tumors, AP-HP, Pitié-Salpêtrière Hospital, Groupe de Recherche Clinique n°16 Tumeurs Thyroïdiennes, Sorbonne Université, Paris, France
UMR9019, Genome Integrity and Cancers, CNRS, Villejuif, France

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Sophie Leboulleux Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy Institut, Villejuif, France

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Françoise Kraeber-Bodéré Nuclear Medicine Department, Université de Nantes, CHU de Nantes, CNRS, Inserm, CRCINA, Nantes, France
CHU Nantes/ICO, Saint-Herblain, France

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Caroline Bodet-Milin Nuclear Medicine Department, Université de Nantes, CHU de Nantes, CNRS, Inserm, CRCINA, Nantes, France
CHU Nantes/ICO, Saint-Herblain, France

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Laure Cabanes Department of Cardiology, APHP, Cochin Hospital, Paris, France
Université de Paris, Paris, France

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Anthony Dohan Radiology Department, Université de Paris, Paris, France
Department of Radiology, AP-HP, Hôpital Cochin, Paris, France

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Pascal Leprince Department of Thoracic and Cardiovascular Surgery, Sorbonne Université, AP-HP, Pitié-Salpêtrière Hospital, Paris, France

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Martin Schlumberger UMR9019, Genome Integrity and Cancers, CNRS, Villejuif, France
Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy Institute, Villejuif, France

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Olivier Huillard Université de Paris, Sorbonne Paris Cité, Paris, France
Department of Medical Oncology, AP-HP, Hôpital Cochin, Paris, France

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Lionel Groussin INSERM Unité 1016, CNRS UMR 8104, Institut Cochin, Paris, France
Université de Paris, Paris, France
Department of Endocrinology, AP-HP, Hôpital Cochin, Paris, France

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12350-013-9826-8 . 13 Ikeoka T , Ito T , Ando T . Left ventricular infiltration from thyroid papillary carcinoma mimicking the electrocardiographic changes of acute myocardial infarction . Endocrine . 2014 ; 47 ( 2 ): 652 – 3

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Diana Grove-Laugesen Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Sofie Malmstroem Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Eva Ebbehoj Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Anne Lene Riis Medical Department, Regional Hospital Horsens, Horsens, Denmark

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Torquil Watt Department of Internal Medicine, Gentofte and Herlev Hospital, Hellerup, Denmark

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Lars Rejnmark Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Klavs Würgler Hansen Medical Department, Silkeborg Regional Hospital, Silkeborg, Denmark

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% increased risk of acute myocardial infarction [ 5 ]. The mechanisms underlying these associations are incompletely understood. Arterial stiffness and blood pressure (BP) have been shown independently to predict cardiovascular morbidity and mortality and

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Roberto Negro Division of Endocrinology, ‘V. Fazzi' Hospital, Lecce

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Giacomo Greco Faculty of Medicine, San Raffaele Hospital, Milan, Italy

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A, Witteman JC: Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med 2000;132:270-278. 10.7326/0003-4819-132-4-200002150-00004 10681281 3

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Eveline Bruinstroop Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands

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Anne H van der Spek Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands

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Anita Boelen Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, the Netherlands

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expression has been observed after myocardial infarction mediated via hypoxia-inducible factor (HIF)–dependent pathways ( 49 , 50 ). Although HIF-1 has been shown to be involved in the progression of liver fibrosis, no direct link between HIF-1 and Dio3 in

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