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Markus Eszlinger Departments of Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
Institute of Pathology, University Hospital Halle (Saale), Halle (Saale), Germany

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Paul Stewardson Department of Medical Science and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada

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John B McIntyre Precision Oncology Hub Laboratory, Alberta Health Services, Tom Baker Cancer Centre, Calgary, Alberta, Canada

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Adrian Box Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada

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Moosa Khalil Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada

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Martin Hyrcza Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada

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Konstantin Koro Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada

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Dean Ruether Section of Medical Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Canada

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Jiahui Wu Department of Medical Science and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada

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Ralf Paschke Departments of Medicine, Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada

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mutation-positive medullary thyroid cancer (MTC) or RET gene fusion-positive thyroid cancer. The early approval of these drugs was based on phase 1/2 data ( 1 , 2 , 3 , 4 , 5 ). Patients with thyroid cancer were one of the larger patient groups in the

Article Type:
Research Article
Collections:
Thyroid cancer - basic and translational
DOI:
https://doi.org/10.1530/ETJ-21-0061
Volume/Issue:
Volume 11: Issue 1
Open access
Thea Riis Department of Endocrinology, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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Steen Joop Bonnema Department of Endocrinology, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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Thomas Heiberg Brix Department of Endocrinology, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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Lars Folkestad Department of Endocrinology, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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Introduction Cancer is the second most common cause of death worldwide and imposes a burden both individually and to the health care systems ( 1 ). It has been suggested that four out of ten cancer cases are preventable ( 2 ). Therefore

Article Type:
Research Article
Collections:
Hyperthyroidism and thyrotoxicosis
DOI:
https://doi.org/10.1530/ETJ-23-0181
Volume/Issue:
Volume 13: Issue 2
Open access
Markus Eszlinger Department of Oncology and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada, and Institute of Pathology, University Hospital Halle, Halle, Germany

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Alexandra Stephenson Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada

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Shideh Mirhadi Program in Cell Biology, Hospital for Sick Children, and Department of Molecular Genetics, University of Toronto, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada

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Konrad Patyra Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland

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Michael F Moran Program in Cell Biology, Hospital for Sick Children, and Department of Molecular Genetics, University of Toronto, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada

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Moosa Khalil Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Jukka Kero Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland
Department of Pediatrics, Turku University Hospital, Turku, Finland

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Ralf Paschke Department of Oncology and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada, and Institute of Pathology, University Hospital Halle, Halle, Germany
Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Department of Medicine, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada

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/hormone synthesis ( 4 , 5 , 6 , 7 , 8 , 9 ). At variance with most other thyroid nodules, current textbooks and guidelines assess HTN as a low cancer risk with no further malignancy evaluation recommended ( 10 ). To understand the role of TSHR signaling in

Article Type:
Research Article
Collections:
Thyroid cancer - basic and translational
DOI:
https://doi.org/10.1530/ETJ-23-0049
Volume/Issue:
Volume 12: Issue 6
Open access
Lan Wu State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

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Salvatore Vaccarella International Agency for Research on Cancer (IARC/WHO), Lyon, France

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Chen-Yang Feng Information Technology Center, Sun Yat-sen University Cancer Center, Guangzhou, China

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Luigino Dal Maso Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy

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Yu Chen State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

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Wei-Wei Liu Department of Head and Neck, Sun Yat-sen University Cancer Center, Guangzhou, China

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Miao-Bian Liang State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

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Zike Zhang Department of Laboratory Medicine, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China

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Jun Yang School of Public Health, Guangzhou Medical University, Guangzhou, China

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Su-Mei Cao State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

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Mengmeng Li State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

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Introduction Thyroid cancer is the most common cancer in the endocrine system, and its incidence rates have increased rapidly worldwide over the past decades, with relatively stable or declining mortality rates ( 1 , 2 ). The diverging gap

Article Type:
Research Article
Collections:
Thyroid cancer - clinical
DOI:
https://doi.org/10.1530/ETJ-23-0127
Volume/Issue:
Volume 12: Issue 6
Open access
Stacey A. Fedewa Surveillance and Health Services Research, American Cancer Society, Atlanta, Ga., USA

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Ahmedin Jemal Surveillance and Health Services Research, American Cancer Society, Atlanta, Ga., USA

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Amy Y. Chen Department of Otolaryngology, Emory University School of Medicine, Atlanta, Ga., USA

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Introduction Each year, 64,300 men and women are diagnosed with thyroid cancer [ 1 ]. Approximately 90% of thyroid cancers are differentiated tumors comprised of papillary and follicular tumors that are commonly diagnosed at an early stage and

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000449379
Volume/Issue:
Volume 5: Issue 4
Free access
Brigitte Decallonne Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium

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Annick Van den Bruel Department of Endocrinology, General Hospital St Jan, Bruges, Belgium

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Gilles Macq Department of Research, Belgian Cancer Registry, Brussels, Belgium

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Nathalie Elaut Department of Research, Belgian Cancer Registry, Brussels, Belgium

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Harlinde De Schutter Department of Research, Belgian Cancer Registry, Brussels, Belgium

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Introduction In Belgium, higher thyroid cancer incidence – most pronounced for microcancers (T1a) – is present in the Southern region, Wallonia, compared to the Northern region, Flanders. In a pioneer national population

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000504046
Volume/Issue:
Volume 9: Issue 1
Free access
Janice Ser Huey Tan Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Timothy Kwang Yong Tay Department of Pathology, Singapore General Hospital, Singapore

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Enya Hui Wen Ong Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Michael Fehlings ImmunoScape, 1 Scotts Road #24-10, Singapore

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Daniel Shao-Weng Tan Division of Medical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Nadiah Binte Sukma Department of Pathology, Singapore General Hospital, Singapore

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Eileen Xueqin Chen Department of Pathology, Singapore General Hospital, Singapore

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Jen-Hwei Sng Department of Pathology, Singapore General Hospital, Singapore

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Connie Siew Poh Yip Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Kok Hing Lim Department of Pathology, Singapore General Hospital, Singapore

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Darren Wan-Teck Lim Division of Medical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Narayanan Gopalakrishna Iyer Division of Surgical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Jacqueline Siok Gek Hwang Department of Pathology, Singapore General Hospital, Singapore

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Melvin Lee Kiang Chua Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Mei-Kim Ang Division of Medical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Introduction Anaplastic thyroid cancers (ATCs) are rare aggressive tumours, comprising only 1–2% of all thyroid cancers worldwide, and are typically associated with high mortality rates and a median overall survival (OS) of 5–12 months ( 1

Article Type:
Research Article
Collections:
Thyroid cancer - clinical
DOI:
https://doi.org/10.1530/ETJ-23-0144
Volume/Issue:
Volume 13: Issue 1
Open access
Constance Xhaard U1018, Centre d'Epidémiologie et de Santé des Populations (CESP), Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France
Institut Gustave Roussy, Villejuif, France
Université Paris-Saclay, Villejuif, France

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Juan J. Lence-Anta National Institute of Oncology and Radiobiology (INOR), Havana, Cuba

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Yan Ren U1018, Centre d'Epidémiologie et de Santé des Populations (CESP), Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France
Institut Gustave Roussy, Villejuif, France
Université Paris-Saclay, Villejuif, France

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Françoise Borson-Chazot Groupement Hospitalier Lyon-Est, Hospices Civils de Lyon, Fédération d'Endocrinologie, Bron
Rhône-Alpes Thyroid Cancer Registry, Cancer Research Center of Lyon (UMR INSERM 1052, CNRS 5286), RTH Laennec Faculty of Medicine, University of Lyon, Lyon

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Geneviève Sassolas Rhône-Alpes Thyroid Cancer Registry, Cancer Research Center of Lyon (UMR INSERM 1052, CNRS 5286), RTH Laennec Faculty of Medicine, University of Lyon, Lyon

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Claire Schvartz Thyroid Cancer Registry of Champagne-Ardennes, Institut Jean Godinot, Reims

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Marc Colonna Cancer Registry of Isère, Meylan

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Brigitte Lacour Institut Gustave Roussy, Villejuif, France
French National Registry of Childhood Solid Tumours, CHU, Nancy

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Arlette Danzon Cancer Registry of Doubs, EA 3181, Université de Franche-Comté, Besançon

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Michel Velten Cancer Registry of Bas-Rhin, EA 3430, Faculty of Medicine, University of Strasbourg, Strasbourg

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Enora Clero U1018, Centre d'Epidémiologie et de Santé des Populations (CESP), Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France
Institut Gustave Roussy, Villejuif, France
Université Paris-Saclay, Villejuif, France

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Stéphane Maillard U1018, Centre d'Epidémiologie et de Santé des Populations (CESP), Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France
Institut Gustave Roussy, Villejuif, France
Université Paris-Saclay, Villejuif, France

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Emilie Marrer Cancer Registry of Haut-Rhin, Mulhouse Hospital, Mulhouse

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Laurent Bailly Public Health Department, University Hospital Nice, Nice

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Eugènia Mariné Barjoan Public Health Department, University Hospital Nice, Nice

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Martin Schlumberger Institut Gustave Roussy, Villejuif, France

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Jacques Orgiazzi Department of Endocrinology, Hospices Civils de Lyon, Lyon, France

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Elisabeth Adjadj U1018, Centre d'Epidémiologie et de Santé des Populations (CESP), Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France
Université Paris-Saclay, Villejuif, France

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Celia M. Pereda National Institute of Oncology and Radiobiology (INOR), Havana, Cuba

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Silvia Turcios National Institute of Endocrinology, Cuba

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Milagros Velasco National Institute of Oncology and Radiobiology (INOR), Havana, Cuba

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Mae Chappe National Institute of Oncology and Radiobiology (INOR), Havana, Cuba

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Idalmis Infante National Institute of Oncology and Radiobiology (INOR), Havana, Cuba

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Marlene Bustillo National Institute of Oncology and Radiobiology (INOR), Havana, Cuba

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Anabel García National Institute of Oncology and Radiobiology (INOR), Havana, Cuba

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Sirced Salazar National Institute of Oncology and Radiobiology (INOR), Havana, Cuba

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Regla Rodriguez Cuban Public Health Ministry, Havana, Cuba

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Mohamed Amine Benadjaoud U1018, Centre d'Epidémiologie et de Santé des Populations (CESP), Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France
Institut Gustave Roussy, Villejuif, France
Université Paris-Saclay, Villejuif, France

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Rosa M. Ortiz National Institute of Oncology and Radiobiology (INOR), Havana, Cuba

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Carole Rubino U1018, Centre d'Epidémiologie et de Santé des Populations (CESP), Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France
Institut Gustave Roussy, Villejuif, France
Université Paris-Saclay, Villejuif, France

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Florent de Vathaire U1018, Centre d'Epidémiologie et de Santé des Populations (CESP), Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France
Institut Gustave Roussy, Villejuif, France
Université Paris-Saclay, Villejuif, France

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Introduction Over the last few decades, the differentiated thyroid cancer (DTC) incidence has grown rapidly in many countries [ 1 ]. The study of DTC risk factors is therefore of great importance to understand this observed increase in

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000445887
Volume/Issue:
Volume 5: Issue 2
Free access
Aamna Hassan Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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Saima Riaz Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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Humayun Bashir Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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M. Khalid Nawaz Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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Raza Hussain Departments of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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Introduction Differentiated thyroid cancer (DTC) is typically indolent if treated early and appropriately. A small subset of more aggressive disease progresses to radioiodine resistance. Based on the American Thyroid Association (ATA) risk of

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000448920
Volume/Issue:
Volume 5: Issue 4
Free access
Patrick W. Owens Discipline of Surgery, Lambe Institute for Translational Research, NUI Galway, Galway, Ireland

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Terri P. McVeigh Discipline of Surgery, Lambe Institute for Translational Research, NUI Galway, Galway, Ireland
Cancer Genetics Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom

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Eoin J. Fahey Discipline of Surgery, Lambe Institute for Translational Research, NUI Galway, Galway, Ireland

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Marcia Bell Department of Endocrinology, Galway University Hospital, Galway, Ireland

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Denis S. Quill Discipline of Surgery, Lambe Institute for Translational Research, NUI Galway, Galway, Ireland

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Michael J. Kerin Discipline of Surgery, Lambe Institute for Translational Research, NUI Galway, Galway, Ireland

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Aoife J. Lowery Discipline of Surgery, Lambe Institute for Translational Research, NUI Galway, Galway, Ireland

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Introduction Thyroid cancer (TC) is the most common endocrine malignancy, accounting for 1% of all cancers, with an incidence of 162 cases per year in Ireland [ 1 ]. The National Cancer Registry Ireland reports increasing incidence of TC from

Article Type:
Guideline
DOI:
https://doi.org/10.1159/000493261
Volume/Issue:
Volume 7: Issue 6
Free access