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Bernadette L Dekker Internal Medicine, Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Anouk N A van der Horst-Schrivers Internal Medicine, Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
Department of Emergency Medicine, Maastricht University Medical Center, Maastricht, the Netherlands

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Adrienne H Brouwers Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Christopher M Shuford Laboratory Corporation of America Holdings, Center for Esoteric Testing, Burlington, North California, USA

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Ido P Kema Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Anneke C Muller Kobold Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Thera P Links Internal Medicine, Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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results of the Tg-IRMA and the Tg-LC-MS/MS and evaluate the clinical concordance of both Tg assays in patients with lower titer TgAbs during 131 I ablation therapy. Materials and methods Patients In this explorative single-center study, we

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Stan R Ursem Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands

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Anita Boelen Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development, Amsterdam, The Netherlands

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Jacquelien J Hillebrand Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands

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Wendy P J den Elzen Department of Laboratory Medicine, Laboratory Specialized Diagnostics & Research, Amsterdam UMC location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Public Health, Amsterdam, The Netherlands

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Annemieke C Heijboer Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development, Amsterdam, The Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location Vrije Universiteit Amsterdam, Boelelaan, Amsterdam, The Netherlands

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. Clinical concordance assessment should be an integral component of laboratory method comparison studies: a regression transference of routine clinical data approach . Clinical Biochemistry 2022 103 25 – 28 . ( https://doi.org/10.1016/j.clinbiochem.2022

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Sofie Larsen Rasmussen Department of Medical Endocrinology, Copenhagen University Hospital Rigshospitalet, Copenhagen

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Lars Rejnmark Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Eva Ebbehøj Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Ulla Feldt-Rasmussen Department of Medical Endocrinology, Copenhagen University Hospital Rigshospitalet, Copenhagen

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Åse Krogh Rasmussen Department of Medical Endocrinology, Copenhagen University Hospital Rigshospitalet, Copenhagen

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Jakob Bue Bjorner QualityMetric (an Optum Company), Lincoln, R.I., USA

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Torquil Watt Department of Medical Endocrinology, Copenhagen University Hospital Rigshospitalet, Copenhagen

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Introduction In clinical trials, questionnaires about health-related quality of life (HRQL) are increasingly used as outcomes for evaluating impact of health on patients' lives and effect of treatment [ 1 , 2 ]. Traditionally, HRQL data has

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Maria Rossing Department of Endocrinology, Herlev University Hospital, Herlev
Center of Genomic Medicine, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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Birte Nygaard Department of Endocrinology, Herlev University Hospital, Herlev

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Finn Cilius Nielsen Center of Genomic Medicine, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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Finn Noe Bennedbæk Department of Endocrinology, Herlev University Hospital, Herlev

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present study is in concordance with the guidelines by the European Thyroid Association, the American Association of Clinical Endocrinologist, and the American Thyroid Association, as they recommend five categories: non-diagnostic, benign, follicular

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Liliana Ribeiro Santos Internal Medicine Department, Hospital of Santa Maria, Lisbon, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal

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Inês Vasconcelos Bessa Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
Health Investigation and Innovation Institute (i3S), University of Porto, Porto, Portugal

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Adriana Gaspar da Rocha Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Health Investigation and Innovation Institute (i3S), University of Porto, Porto, Portugal
Public Health Unit, ACES Baixo Mondego, Coimbra, Portugal

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Celestino Neves Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
Department of Endocrinology, Hospital University Centre of São João, Porto, Portugal

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Cláudia Freitas Department of Endocrinology, Hospital University Centre of Porto, Porto, Portugal

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Paula Soares Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
Health Investigation and Innovation Institute (i3S), University of Porto, Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto, Porto, Portugal

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and tends to appear in younger patients than HT. In about one-third of GD patients, ophthalmic signs eventually emerge ( 3 ). These disorders have shared susceptibility factors, and studies have demonstrated concordance rates of 55% in monozygotic

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Amanda La Greca Endocrinology Service, Department of Medicine, New York, N.Y., USA

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Bin Xu Department of Pathology, Memorial Sloan-Kettering Cancer Center and Weill-Cornell College of Medicine, New York, N.Y., USA

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Ronald Ghossein Department of Pathology, Memorial Sloan-Kettering Cancer Center and Weill-Cornell College of Medicine, New York, N.Y., USA

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R. Michael Tuttle Endocrinology Service, Department of Medicine, New York, N.Y., USA

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Mona M. Sabra Endocrinology Service, Department of Medicine, New York, N.Y., USA

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6- to 12-month intervals thereafter at the discretion of the treating physician. The frequency of the follow-up visits was based on the estimated risk of recurrence for each individual patient and the clinical course of the disease. Clinical

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J L Reverter Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain

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L Ferrer-Estopiñan Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain

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F Vázquez Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain

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S Ballesta Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain

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S Batule Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain

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A Perez-Montes de Oca Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain

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C Puig-Jové Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain

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M Puig-Domingo Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain

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benign lesions ( 4 ). Based on these characteristics, US risk stratification systems (RSS) have been designed to standardize reports and to make the clinical decision-making process easier ( 5 ). Nevertheless, the presence of interoperator variation is

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Birte Nygaard Departments of Endocrinology, Herlev Hospital, Copenhagen

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Jens Bentzen Departments of Oncology, Herlev Hospital, Copenhagen

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Peter Laurberg Department of Endocrinology, Aalborg Hospital, Aalborg

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Susanne Møller Pedersen Departments of Biochemistry, Odense University Hospital, Odense

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Lars Bastholt Departments of Oncology, Odense University Hospital, Odense

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Aase Handberg Departments of Biochemistry, Aarhus Hospital, Aarhus, Denmark

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Carsten Rytter Departments of Oncology, Aarhus Hospital, Aarhus, Denmark

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Christian Godballe ENT Head and Neck Surgery, Odense University Hospital, Odense

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Jens Faber Departments of Endocrinology, Herlev Hospital, Copenhagen

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different methods of Tg-Ab measurements showed only a 65% concordance between assays [ 11 ] and handling of problems with Tg-Ab interference in clinical practice remains controversial. The purpose of the present study was to evaluate the s-Tg and s

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Claire L Wood Department of Paediatric Endocrinology, Great North Children’s Hospital, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK

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Niamh Morrison Department of Paediatric Endocrinology, Great North Children’s Hospital, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK

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Michael Cole Population Health Sciences Institute, Newcastle University, Baddiley-Clark Building, Newcastle upon Tyne, UK

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Malcolm Donaldson Department of Child Health, University of Glasgow School of Medicine, Glasgow, UK

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David B Dunger Department of Paediatrics, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK
Wellcome Trust-MRC Institute of Metabolic Sciences, University of Cambridge, Cambridge, UK

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Ruth Wood Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK

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Simon H S Pearce Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
Department of Endocrinology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK

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Timothy D Cheetham Department of Paediatric Endocrinology, Great North Children’s Hospital, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK

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function checked at each visit. Unscheduled visits (sometimes with associated thyroid function tests) could take place between these assessments as clinically indicated. Table 1 Instructions for initial anti-thyroid drug (ATD) treatment. The primary

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Yulia P. Sych Department of Endocrinology 1 at I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation

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Valentin V. Fadeev Department of Endocrinology 1 at I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation

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Elena P. Fisenko Laboratory of Ultrasound Diagnostics, Federal State Research Institution “B.V. Petrovsky National Research Centre of Surgery”, Moscow, Russian Federation

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Marina Kalashnikova Department of Endocrinology 1 at I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation

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reproducibility. This study evaluated the concordance between observers who used a modified version of the earlier TIRADS by Kwak et al. [ 5 ] and the later European version of TIRADS [ 4 ] for the diagnostics of thyroid nodule. Kw-TIRADS stratifies thyroid

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