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Dear Sir, The results of the long awaited Antenatal Thyroid Screening and Childhood Cognitive Function study have finally been published in the New England Journal of Medicine after a preliminary presentation of findings at the
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. Secondary outcomes included impacts on heart rate, body composition, and cognitive function. Clinical Parameters QoL was measured by an online version of ThyPRO-39 [ 9 - 12 ]. The questionnaire was answered at home before each visit and 12 months
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Introduction Thyroid hormones (THs), T3 (3,5,3′-triiodo- l -thyronine), and T4 (3,5,3′,5′-tetraiodo- l -thyronine) are essential for the correct development and functioning of most organs. The thyroid gland mostly secretes T4, which is
Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Wallenberg’s Centre of Molecular and Translational Medicine, Region Västra Götaland, Sweden
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Department of Pedagogical, Curricular and Professional Studies, Faculty of Education, University of Gothenburg, Gothenburg, Sweden
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Wallenberg’s Centre of Molecular and Translational Medicine, Region Västra Götaland, Sweden
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considered separately as the treatment options differ depending on the condition. The aim of this study was to assess mental fatigue, depression, anxiety, and cognitive function in GD patients in the hyperthyroid phase and after 15 months of treatment, with
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of autoimmune disease on the brain, have to be considered. It is therefore desirable to analyze the influence of an excess of thyroid hormones on brain morphology and cognitive functions in an experimental setting. Such studies have been performed
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, Dhaliwal SS, Chew GT, Bhagat MC, Cussons AJ: Combined thyroxine/liothyronine treatment does not improve well-being, quality of life, or cognitive function compared to thyroxine alone: a randomized controlled trial in patients with primary hypothyroidism. J
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-0548 27879326 0804-4643 39 Lazarus JH , Bestwick JP , Channon S , Paradice R , Maina A , Rees R , et al. Antenatal thyroid screening and childhood cognitive function . N Engl J Med . 2012 Feb ; 366 ( 6 ): 493 – 501 . 10.1056/NEJMoa
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hypothyroidism. The primary endpoints of the trial include a combined cardiovascular endpoint and thyroid-specific quality of life. Secondary endpoints include overall mortality, quality of life, functional capacity, and cognitive function. Analyses of this trial
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-0414 16804044 30 Wekking EM, Appelhof BC, Fliers E, Schene AH, Huyser J, Tijssen JG, Wiersinga WM: Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism. Eur J Endocrinol 2005
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Steno Diabetes Center North Jutland, Aalborg University Hospital, Aalborg, Denmark
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Channon S Paradice R Maina A Rees R Chiusano E John R Guaraldo V George LM Antenatal thyroid screening and childhood cognitive function . New England Journal of Medicine 2012 366 493 – 501 . ( https://doi.org/10.1056/NEJMoa1106104 ) 24
