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Institute of Public Health, University of Copenhagen
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National Research Centre for the Working Environment, Copenhagen
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Department of Palliative Medicine, Bispebjerg Hospital
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: Health-related quality of life in patients with thyroid disorders. Qual Life Res 2004;13:45–54. 10.1023/B:QURE.0000015315.35184.66 15058786 3 Saravanan P, Chau WF, Roberts N, Vedhara K, Greenwood R, Dayan CM: Psychological well-being in patients
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Introduction In clinical trials, questionnaires about health-related quality of life (HRQL) are increasingly used as outcomes for evaluating impact of health on patients' lives and effect of treatment [ 1 , 2 ]. Traditionally, HRQL data has
OPEN, Odense Patient Data Explorative Network, Odense University Hospital, Odense, Denmark
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Center [ 27 ]. Health-Related Quality of Life Changes in HRQoL were measured by the thyroid-related patient-reported outcome (ThyPRO) instrument, recently recommended as the only validated tool for evaluating HRQoL in patients with benign thyroid
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may provide other beneficial effects (e.g. on mood and health-related quality of life; HRQoL) in patients with Hashimoto's thyroiditis [ 11 ]. We performed a systematic review to assess the effects of selenium supplementation for Hashimoto
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Objective: Subclinical hyperthyroidism (SCH) is common and associated with atrial fibrillation (AF) risk in the elderly. Current guidelines rely on a low level of evidence.
Methods: Randomized clinical trial including patients 50 years and older, with TSH <0.4 mU/L and normal thyroid hormone concentrations. All patients showed autonomy on thyroid scan. They were randomized either to receive radioiodine (I131) or to be monitored and treated only if they underwent AF or evolved towards overt hyperthyroidism. Primary outcome was the onset of new AF. Secondary outcomes were treatment-induced hypothyroidism rate and health-related quality of life.
Results: 144 patients (mean age 65.3±8.9y, 76% female) were randomized, 74 to surveillance and 70 to treatment. Four patients in the surveillance group and one in the treatment group developed AF (p=0.238). However, the patient who developed AF in the treatment group maintained TSH <0.4 mU/L at AF onset. A post-hoc analysis was carried out and showed that when normalization of TSH was considered, the risk of AF was significantly reduced (p=0.0003). In the surveillance group, several patients showed no classical characteristics associated with AF risk, including age>65y or TSH<0.1mU/L. Of 94 patients treated using radioiodine, 25% developed hypothyroidism during follow-up.
Conclusions: Due to recruitment difficulties this study failed to demonstrate that SCH treatment can reduce significantly the incidence of AF in patients older than 50 years with thyroid autonomy even if all the patients who developed AF maintained TSH <0.4 mU/L. This result must be balanced with the increased risk of radioiodine-induced hypothyroidism.
Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden
The National Task Force in Hyperthyroidism, Swedish National System for Knowledge-Driven Management, Umeå, Sweden
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Department of Endocrinology and Diabetes, Örebro University Hospital, Örebro, Sweden
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Thyroid Federation International, Kungsbacka, Sweden
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Swedish Thyroid Association, Stockholm, Sweden
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Swedish Thyroid Association, Stockholm, Sweden
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Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden
The National Task Force in Hyperthyroidism, Swedish National System for Knowledge-Driven Management, Umeå, Sweden
Sweden and Wallenberg Center for Molecular and Translational Medicine, Västra Götaland Region, Göteborg, Sweden
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– 204 . ( https://doi.org/10.1210/jcem-44-1-203 ) 9 Wilson IB & Cleary PD . Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes . JAMA 1995 273 59 – 65 . ( https://doi.org/10.1001/jama.1995
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Terwee CB , Dekker FW , Prummel MF , Wiersinga WM . Graves’ ophthalmopathy through the eyes of the patient: a state of the art on health-related quality of life assessment . Orbit . 2001 ; 20 ( 4 ): 281 – 90 . http://dx.doi.org/10.1076/orbi.20
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KH, Choy TS, et al: Health-related quality-of-life study in patients with carcinoma of the thyroid after thyroxine withdrawal for whole body scanning. Laryngoscope 2006;116:2060-2066. 10.1097/01.mlg.0000240287.57704.01 17075410 7 Tagay S
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as diarrhoea, which are not addressed by the currently available thyroid cancer QoL questionnaires. The aim of the QaLM study (Assessment of Q u a lity of L ife Tools in M edullary Thyroid Cancer) was to determine which Health Related Quality of
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hypothyroidism, has been strongly associated with clinical decline and impaired quality of life (QoL) ( 7 ). Apart from some small cross-sectional studies, the role of Se in brain function and in the modulation of psychological states via large cohort studies has
