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Yingxin Fang Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Pingping Dang Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Yue Liang Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Defa Zhao Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Ranran Wang Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Yue Xi Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China
Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, People’s Republic of China

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Dan Zhang Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China
Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, People’s Republic of China

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Wei Wang Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Zhongyan Shan Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Weiping Teng Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Xiaochun Teng Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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, the cognitive deficits typically remain ( 7 ). Mounting evidence suggests that as one of the most extensively investigated regions in the brain, the hippocampus mediates cognitive functions, notably, learning, and memory functions. In both animals and

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Anna Göbel Departments of Neurology, University of Lübeck, Lübeck, Germany

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Marcus Heldmann Departments of Neurology, University of Lübeck, Lübeck, Germany

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Martin Göttlich Departments of Neurology, University of Lübeck, Lübeck, Germany

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Anna-Luise Dirk Departments of Internal Medicine I, University of Lübeck, Lübeck, Germany

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Georg Brabant Departments of Internal Medicine I, University of Lübeck, Lübeck, Germany

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Thomas F. Münte Departments of Neurology, University of Lübeck, Lübeck, Germany

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] revealed reduced GMV in the hippocampus, parahippocampal gyrus, calcarine region, lingual gyrus and left temporal pole, and increased GMV in the supplementary motor area bilaterally. Again, no differences were seen for the cerebellum. Using metabolic

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Suresh Kumar Bunker Department of Biotechnology, Utkal University, Bhubaneswar, India

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Jagneshwar Dandapat Department of Biotechnology, Utkal University, Bhubaneswar, India

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Gagan B.N. Chainy Department of Biotechnology, Utkal University, Bhubaneswar, India

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Sunil Kumar Sahoo Department of Biotechnology, Utkal University, Bhubaneswar, India

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Prabhat Kumar Nayak Department of Biotechnology, Utkal University, Bhubaneswar, India

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11746232 21 Sui L, Li BM: Effects of perinatal hypothyroidism on regulation of reelin and brain-derived neurotrophic factor gene expression in rat hippocampus: role of DNA methylation and histone acetylation. Steroids 2010; 75: 988–997. 10.1016/j

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Julia Müller Leibniz Institute for Age Research/Fritz Lipmann Institute, Jena, Germany

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Heike Heuer Leibniz Institute for Age Research/Fritz Lipmann Institute, Jena, Germany

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as well as in the hippocampus and striatum where it has been speculated to mediate neuronal T 3 uptake [ 37 ]. Moreover, Mct8 was also localized in choroid plexus structures and in brain capillary endothelial cells where it may participate in the

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Heleen I Jansen Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands

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Antonius E van Herwaarden Radboud University Medical Center, Department of Laboratory Medicine, Nijmegen, The Netherlands

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Henk J Huijgen Department of Clinical Chemistry, Red Cross Hospital, Beverwijk, The Netherlands

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Rebecca C Painter Department of Obstetrics and Gynaecology, Amsterdam UMC Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands

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Jacquelien J Hillebrand Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands

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Anita Boelen Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands

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Annemieke C Heijboer Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands

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.1007/s00404-010-1362-z ) 4 Willoughby KA McAndrews MP Rovet JF . Effects of maternal hypothyroidism on offspring hippocampus and memory . Thyroid 2014 24 576 – 584 . ( https://doi.org/10.1089/thy.2013.0215 ) 5 Haddow JE Palomaki GE Allan

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Josef Köhrle Institut für Experimentelle Endokrinologie, Charité Campus Virchow-Klinikum (CVK), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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, Pierozan P , Dos Santos K , et al. Reverse T 3 interacts with αvβ3 integrin receptor and restores enzyme activities in the hippocampus of hypothyroid developing rats: insight on signaling mechanisms . Mol Cell Endocrinol . 2018 Jul ; 470 : 281 – 94

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