Janice Ser Huey Tan
Janice Ser Huey Tan
Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Timothy Kwang Yong Tay
Timothy Kwang Yong Tay
Department of Pathology, Singapore General Hospital, Singapore
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Enya Hui Wen Ong
Enya Hui Wen Ong
Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Michael Fehlings
Michael Fehlings
ImmunoScape, 1 Scotts Road #24-10, Singapore
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Daniel Shao-Weng Tan
Daniel Shao-Weng Tan
Division of Medical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Nadiah Binte Sukma
Nadiah Binte Sukma
Department of Pathology, Singapore General Hospital, Singapore
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Eileen Xueqin Chen
Eileen Xueqin Chen
Department of Pathology, Singapore General Hospital, Singapore
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Jen-Hwei Sng
Jen-Hwei Sng
Department of Pathology, Singapore General Hospital, Singapore
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Connie Siew Poh Yip
Connie Siew Poh Yip
Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Kok Hing Lim
Kok Hing Lim
Department of Pathology, Singapore General Hospital, Singapore
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Darren Wan-Teck Lim
Darren Wan-Teck Lim
Division of Medical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Narayanan Gopalakrishna Iyer
Narayanan Gopalakrishna Iyer
Division of Surgical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Jacqueline Siok Gek Hwang
Jacqueline Siok Gek Hwang
Department of Pathology, Singapore General Hospital, Singapore
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Melvin Lee Kiang Chua
Melvin Lee Kiang Chua
Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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Mei-Kim Ang
Mei-Kim Ang
Division of Medical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore
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methods Patient selection Consecutive patients with newly diagnosed ATC at a single institution with ECOG ≤2, adequate organ function, no active autoimmune disease and contraindications to immunotherapy were included. Diagnosis and pathology of all
Alessandro Brancatella
Alessandro Brancatella
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Laura Pierotti
Laura Pierotti
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Nicola Viola
Nicola Viola
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Isabella Lupi
Isabella Lupi
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Lucia Montanelli
Lucia Montanelli
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Chiara Cremolini
Chiara Cremolini
Oncology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
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Paolo Piaggi
Paolo Piaggi
Department of Information Engineering, University of Pisa, Pisa, Italy
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Antonio Chella
Antonio Chella
Pneumology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy
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Andrea Antonuzzo
Andrea Antonuzzo
Oncology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
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Daniele Sgrò
Daniele Sgrò
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Lucia Antonangeli
Lucia Antonangeli
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Chiara Sardella
Chiara Sardella
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Sandra Brogioni
Sandra Brogioni
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Claudio Marcocci
Claudio Marcocci
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Ferruccio Santini
Ferruccio Santini
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Francesco Latrofa
Francesco Latrofa
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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(i.e. subacute thyroiditis and type 2 amiodarone-induced thyrotoxicosis) ( 9 , 10 ), recent guidelines and expert opinion recommend no treatment for the destructive forms induced by immunotherapy, since data in this setting are lacking ( 3 , 11
Alan Chun Hong Lee
Alan Chun Hong Lee
Division of Endocrinology and Metabolism, Department of Medicine, Queen Mary Hospital, Hong Kong, China
Department of Medicine I, Johannes Gutenberg University Medical Center, Mainz, Germany
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Department of Medicine I, Johannes Gutenberg University Medical Center, Mainz, Germany
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George J. Kahaly
George J. Kahaly
Department of Medicine I, Johannes Gutenberg University Medical Center, Mainz, Germany
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]. ATX-GD-59 Rationale and Mechanisms of Actions. Antigen-specific immunotherapy is an effective treatment for common allergic conditions, especially atopy (allergic rhinitis/conjunctivitis, asthma, atopic dermatitis) and stinging insect
Junyu Tong
Junyu Tong
Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Maomei Ruan
Maomei Ruan
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
Department of Nuclear Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China
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Department of Nuclear Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China
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Yuchen Jin
Yuchen Jin
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Hao Fu
Hao Fu
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Lin Cheng
Lin Cheng
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Qiong Luo
Qiong Luo
Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China
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Zhiyan Liu
Zhiyan Liu
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Zhongwei Lv
Zhongwei Lv
Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China
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Libo Chen
Libo Chen
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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therapy, differentiation therapy, and immunotherapy are primarily used for thyroid carcinomas poorly controlled by traditional treatment, although most of the relevant researches remain ongoing. Molecular targeted therapy Inhibiting angiogenesis and
Susanne Neumann
Susanne Neumann
Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda, Bethesda, Maryland, USA
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Christine C. Krieger
Christine C. Krieger
Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda, Bethesda, Maryland, USA
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Marvin C. Gershengorn
Marvin C. Gershengorn
Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda, Bethesda, Maryland, USA
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’s clinical activity score and exophthalmos was observed [ 24 ]. K1–70 is a promising treatment option and currently in phase I clinical trials (https://Clinical Trials.gov/show/NCT02904330) [ 25 ]. Recently, antigen-specific immunotherapies have been
Earn H. Gan
Earn H. Gan
Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, United Kingdom
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Anna L. Mitchell
Anna L. Mitchell
Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, United Kingdom
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Ruth Plummer
Ruth Plummer
Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, United Kingdom
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Simon Pearce
Simon Pearce
Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, United Kingdom
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Petros Perros
Petros Perros
Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, United Kingdom
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What Is Known about This Topic? Anti-CTLA-4 immunotherapy used in cancer treatment can cause thyroiditis and Graves disease. What Does This Case Report Add? Transient thyroiditis and Graves disease usually take place within
Jaume Capdevila
Jaume Capdevila
Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology (VHIO), IOB Quiron-Teknon, Barcelona, Spain
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Desiree’ Deandreis
Desiree’ Deandreis
Department of Medical Sciences, Nuclear Medicine Unit, University of Turin, AOU Città della Salute e della Scienza, Turin, Italy
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Cosimo Durante
Cosimo Durante
Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
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Sophie Leboulleux
Sophie Leboulleux
Service of Endocrinology, Diabetology, University Hospital Geneve, Geneve, Switzerland
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Markus Luster
Markus Luster
Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany
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Romana Netea-Maier
Romana Netea-Maier
Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands
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Kate Newbold
Kate Newbold
Royal Marsden Hospital, London, United Kingdom
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Susanne Singer
Susanne Singer
Institute of Medical Biostatistics Epidemiology and Informatics (IMBEI), University Medical Center of Johannes Gutenberg University, Mainz, Germany
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Gerasimos P Sykiotis
Gerasimos P Sykiotis
Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
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Beate Bartes
Beate Bartes
Association “Vivre sans Thyroïde”, Léguevin, France
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Kate Farnell
Kate Farnell
Butterfly Thyroid Cancer Trust, Rowlands Gill, Tyne & Wear, UK
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Laura Deborah Locati
Laura Deborah Locati
Medical Oncology Unit, IRCCS ICS Maugeri, Pavia, Italy
Department of Internal Medicine and Therapeutics, University of Pavia, Italy
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Department of Internal Medicine and Therapeutics, University of Pavia, Italy
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patients with DTC treated with lenvatinib. Even though the therapeutic landscape in RAI-R DTC is evolving, with new targeted therapies, immunotherapy, etc., lenvatinib is expected to remain a first-line treatment and mainstay of therapy for several years in
Pauline Campredon
Pauline Campredon
Department of Endocrinology and Metabolic Diseases, Larrey University Hospital, Toulouse, France
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Philippe Imbert
Philippe Imbert
Ophthalmologist, Clinique du Parc, Toulouse, France
Multidisciplinary Thyroid Eye Consultation, Department of Endocrinology, Larrey University Hospital, Toulouse, France
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Multidisciplinary Thyroid Eye Consultation, Department of Endocrinology, Larrey University Hospital, Toulouse, France
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Céline Mouly
Céline Mouly
Department of Endocrinology and Metabolic Diseases, Larrey University Hospital, Toulouse, France
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Solange Grunenwald
Solange Grunenwald
Department of Endocrinology and Metabolic Diseases, Larrey University Hospital, Toulouse, France
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Julien Mazières
Julien Mazières
Department of Pneumology, Larrey University Hospital, Toulouse, France
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Philippe Caron
Philippe Caron
Department of Endocrinology and Metabolic Diseases, Larrey University Hospital, Toulouse, France
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What Is Known about This Topic? Anti-PD-1 monoclonal antibody therapy is associated with immune-related adverse events, and the most frequent is inflammatory thyroiditis. During immunotherapy, immune-related ocular toxicities are
Hippolyte Dupuis
Hippolyte Dupuis
Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France
University of Lille, Lille, France
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University of Lille, Lille, France
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Emilie Merlen
Emilie Merlen
Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France
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Arnaud Jannin
Arnaud Jannin
Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France
University of Lille, Lille, France
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University of Lille, Lille, France
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Philippe Jamme
Philippe Jamme
University of Lille, Lille, France
Department of Dermatology, Lille University Hospital, Lille, France
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Department of Dermatology, Lille University Hospital, Lille, France
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Alexandre Fagart
Alexandre Fagart
Department of Nuclear Medicine, Valenciennes Hospital Center, Valenciennes, France
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Marie-Christine Vantyghem
Marie-Christine Vantyghem
Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France
University of Lille, Lille, France
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University of Lille, Lille, France
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Miriam Ladsous
Miriam Ladsous
Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France
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.1056/NEJMoa1709030 ) 2 Antonelli A Ferrari SM Fallahi P . Current and future immunotherapies for thyroid cancer . Expert Review of Anticancer Therapy 2018 18 149 – 159 . ( https://doi.org/10.1080/14737140.2018.1417845 ) 3 Illouz F Drui D Caron
Alessandro Brancatella
Alessandro Brancatella
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy
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Nicola Viola
Nicola Viola
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy
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Sandra Brogioni
Sandra Brogioni
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy
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Lucia Montanelli
Lucia Montanelli
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy
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Chiara Sardella
Chiara Sardella
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy
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Paolo Vitti
Paolo Vitti
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy
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Claudio Marcocci
Claudio Marcocci
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy
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Isabella Lupi
Isabella Lupi
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy
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Francesco Latrofa
Francesco Latrofa
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy
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autoimmune hyperthyroidism and Graves’ ophthalmopathy. Of note, euthyroid Graves’ ophthalmopathy is very uncommon after other immunotherapy drugs (e.g., interferon and alemtuzumab); in these settings, ophthalmopathy is usually associated with hyperthyroidism
