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  • interference with TgAb x
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Eijun Nishihara Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Yoshitaka Hobo ASKA Pharmamedical Co., Ltd. Fujisawa, Japan

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Akira Miyauchi Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Yasuhiro Ito Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Miyoko Higuchi Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsuyoshi Hirokawa Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsuru Ito Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Shuji Fukata Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsushige Nishikawa Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Takashi Akamizu Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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interference with TgAb may lead to Tg values that are lower than expected or even undetectable. This Tg underestimation is considered the most serious clinical problem for the clinical follow-up of postoperative patients with DTCs. Liquid chromatography

Article Type:
Research Article
Collections:
Thyroid function tests
DOI:
https://doi.org/10.1530/ETJ-21-0041
Volume/Issue:
Volume 11: Issue 1
Open access
Bernadette L Dekker Internal Medicine, Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Anouk N A van der Horst-Schrivers Internal Medicine, Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
Department of Emergency Medicine, Maastricht University Medical Center, Maastricht, the Netherlands

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Adrienne H Brouwers Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Christopher M Shuford Laboratory Corporation of America Holdings, Center for Esoteric Testing, Burlington, North California, USA

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Ido P Kema Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Anneke C Muller Kobold Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Thera P Links Internal Medicine, Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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positivity and its relationship with Tg assay interference is still a point of discussion ( 3 ). Tg interpretation can be challenging since even low TgAb titers can interfere analytically with current Tg assays ( 4 ). However, recently, Côrtes et al. and

Article Type:
Research Article
Collections:
Thyroid cancer - clinical
DOI:
https://doi.org/10.1530/ETJ-22-0137
Volume/Issue:
Volume 11: Issue 6
Open access
Birte Nygaard Departments of Endocrinology, Herlev Hospital, Copenhagen

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Jens Bentzen Departments of Oncology, Herlev Hospital, Copenhagen

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Peter Laurberg Department of Endocrinology, Aalborg Hospital, Aalborg

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Susanne Møller Pedersen Departments of Biochemistry, Odense University Hospital, Odense

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Lars Bastholt Departments of Oncology, Odense University Hospital, Odense

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Aase Handberg Departments of Biochemistry, Aarhus Hospital, Aarhus, Denmark

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Carsten Rytter Departments of Oncology, Aarhus Hospital, Aarhus, Denmark

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Christian Godballe ENT Head and Neck Surgery, Odense University Hospital, Odense

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Jens Faber Departments of Endocrinology, Herlev Hospital, Copenhagen

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different methods of Tg-Ab measurements showed only a 65% concordance between assays [ 11 ] and handling of problems with Tg-Ab interference in clinical practice remains controversial. The purpose of the present study was to evaluate the s-Tg and s

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000341362
Volume/Issue:
Volume 1: Issue 3
Free access
Marta Amaro da Silveira Duval Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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André Borsatto Zanella Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Ana Patrícia Cristo Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Carlo Sasso Faccin Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Marcia Silva Graudenz Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Ana Luiza Maia Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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situation, with higher cutoffs suggested in non-thyroidectomized patients [ 16 ]. Moreover, one study suggests that positive serum anti-thyroglobulin antibodies (TgAb) lowered FNA-Tg levels and influenced the diagnostic accuracy of FNA-Tg in suspicious LNs

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000479682
Volume/Issue:
Volume 6: Issue 6
Free access
Carla Gambale Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Alessandro Prete Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Lea Contartese Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Liborio Torregrossa Department of Surgical, Medical, Molecular Pathology and Critical Area, Anatomic Pathology Section, University Hospital of Pisa, Pisa, Italy

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Francesca Bianchi Department of Nuclear Medicine, University Hospital of Pisa, Pisa, Italy

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Eleonora Molinaro Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Gabriele Materazzi Department of Surgical, Medical, Molecular Pathology and Critical Area, Unit of Endocrine Surgery, University Hospital of Pisa, Pisa, Italy

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Rossella Elisei Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Antonio Matrone Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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(AiaPack TgAb Tosoh Corporation, Tokyo, Japan) with a normal range between 0 and 30 U/mL and a Tg interference value of 8 UI/mL, determined in our laboratory ( 13 ). Neck US Neck US was performed by endocrinologists with more than 5 years of

Article Type:
Research Article
Collections:
Thyroid cancer - clinical
DOI:
https://doi.org/10.1530/ETJ-23-0052
Volume/Issue:
Volume 12: Issue 6
Open access
Federica D’Aurizio Department of Laboratory Medicine, Institute of Clinical Pathology, University Hospital of Udine, Udine, Italy

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Alessia Biasotto Department of Medicine, University of Udine, Udine, Italy

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Claudia Cipri Endocrinology, Metabolism and Clinical Nutrition Unit, University Hospital of Udine, Udine, Italy

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Franco Grimaldi Endocrinology, Metabolism and Clinical Nutrition Unit, University Hospital of Udine, Udine, Italy

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Jessica Zucco Department of Laboratory Medicine, Institute of Clinical Pathology, University Hospital of Udine, Udine, Italy

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Stefania Marzinotto Department of Laboratory Medicine, Institute of Clinical Pathology, University Hospital of Udine, Udine, Italy

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Francesco Curcio Department of Laboratory Medicine, Institute of Clinical Pathology, University Hospital of Udine, Udine, Italy
Department of Medicine, University of Udine, Udine, Italy

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Salvatore Benvenga Department of Clinical and Experimental Medicine, Endocrinology Section, University of Messina, Messina, Italy

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with the others ( 4 ). In such cases, analytical interferences should be investigated in order to avoid unnecessary further diagnostic procedures and/or treatments ( 5 ). In fact, despite numerous advances in immunoassay technology, thyroid hormone

Article Type:
Case Report
Collections:
Thyroid function tests
DOI:
https://doi.org/10.1530/ETJ-21-0088
Volume/Issue:
Volume 11: Issue 3
Open access
Irene Campi Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy

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Marco Dell’Acqua Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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Elisa Stellaria Grassi Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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Maria Cristina Vigone Department of Paediatrics, IRCCS San Raffaele Hospital, Milan, Italy

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Luca Persani Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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). Assay interferences Analytical interferences in thyroid function tests (TFTs) can result in diagnostic delays, unnecessary testing, and inappropriate treatments. A recent review of 150 patients with interferences in TFTs shows that in more than 50

Article Type:
Review Article
Collections:
Hypothyroidism
DOI:
https://doi.org/10.1530/ETJ-23-0012
Volume/Issue:
Volume 12: Issue 4
Open access
Ilaria Muller Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Italy

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Anita Daturi Department of Clinical Sciences and Community Health, University of Milan, Italy

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Matteo Varallo Department of Clinical Sciences and Community Health, University of Milan, Italy

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Tiziana E Re Internal Medicine - High Intensity of Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Davide Dazzi Casa di Cura Val Parma SRL, Langhirano (Parmigiano: Langhiràn), Italy

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Sara Maioli Department of Clinical Sciences and Community Health, University of Milan, Italy

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Erica Crivicich Department of Clinical Sciences and Community Health, University of Milan, Italy

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Francesco Di Marco Department of Clinical Sciences and Community Health, University of Milan, Italy

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Virgilio Longari Nuclear Medicine Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Beatrice Dazzi Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Massimo Castellani Nuclear Medicine Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Giovanna Mantovani Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Italy

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Maura Arosio Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Italy

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Mario Salvi Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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3 months post-infection in 65 patients and detected in 8 (12%; 6 TgAb and TPOAb, 2 only TgAb); there was no difference in thyroid autoantibodies prevalence between patients with or without areas of focal hypoechogenicity at US ( P  = 0.56). At 6 and

Article Type:
Research Article
Collections:
Thyroid function tests
DOI:
https://doi.org/10.1530/ETJ-22-0200
Volume/Issue:
Volume 12: Issue 2
Open access
Fabián Pitoia Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina

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Erika Abelleira Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina

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Graciela Cross Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina

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of antithyroglobulin antibodies (TgAb) measured by ultrasensitive assay at the time of ablation. Patients had to be followed up over at least 36 months. M0 status was initially evaluated with chest CT scan in high-risk patients and then confirmed by

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000369135
Volume/Issue:
Volume 3: Issue 4
Free access
Caiyan Mo Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Han Chen Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Qi Zhang Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Ying Guo Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Liyong Zhong Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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when clinical or biochemical differences occur ( 38 ). Therefore, we recommend serial dilution and measuring thyroid function with different analytical platforms to exclude assay interference. Besides, it has been reported that elevated serum

Article Type:
Review Article
Collections:
Hyperthyroidism and thyrotoxicosis
DOI:
https://doi.org/10.1530/ETJ-22-0223
Volume/Issue:
Volume 12: Issue 4
Open access