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.2-0.5% in pregnancy and which will not be considered further in this guideline. In children the prevalence of SCH is less than 2% [ 5 ]. When considering SCH, it was agreed that the so-called isolated hypothyroxinaemia as a separate entity should also be
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Introduction In recent decades, a new concept has been defined with regard to thyroid hormone (TH) function during early pregnancy: isolated hypothyroxinaemia (IH) ( 1 , 2 ). This refers to the condition of women with low free thyroxin (FT4
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hypothyroxinaemia, utilizing the more stringent pregnancy value may identify those subjects with a significantly low FT 4 who may exhibit neuropsychological benefit from L -thyroxine replacement. Treatment of isolated hypothyroxinaemia is currently not recommended
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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function have drawn much attention in pregnant women, specifically. A main focus on maternal T4 in pregnancy emerged before TSH assays were available. With the advancement of assays, the concept of “isolated hypothyroxinemia” emerged. No
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.74 mIU/L and subclinical hyperthyroidism was defined as a serum TSH level <0.06 mIU/L together with a normal FT4 level (10.29–18.02 pmol/L), respectively. Isolated hypothyroxinaemia (IH) was defined as an FT4 level <2.5th percentile (10.29 pmol/L) with
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Maiter D Bernard P & Daumerie C . First trimester isolated maternal hypothyroxinaemia: adverse maternal metabolic profile and impact on the obstetrical outcome . Clinical Endocrinology 2017 86 576 – 583 . ( https://doi.org/10.1111/cen.13301
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report that isolated hypothyroxinemia does not affect pregnancy and child development [ 23 , 24 ]. However, there are studies that show hypothyroxinemia, especially in the early stages of pregnancy, is a predictor of lower motor and intellectual
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disruption [ 9 , 18 , 19 ]. Another point is that those studies that investigated the effects of T 4 supplementation in women with subclinical hypothyroidism or hypothyroxinaemia on the offspring’s IQ [see, for instance, 20 ] did not take into account
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unselected group of women consulting for infertility, 5% had isolated positive Tg-Abs, compared with 4% with TPO-Abs only. In the NHANES III study, increased levels of Tg-Abs were not associated with thyroid function compared with increased TPO-Abs [ 11
Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France
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Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France
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isolated maternal hypothyroxinemia with impaired neurocognitive development in the offspring is debated [ 2 , 5 , 6 , 7 ]. Iodine has a central role in the thyroid economy, particularly in pregnancy. Therefore, there are efforts worldwide to eradicate