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John Lazarus Thyroid Research Group, Institute of Molecular Medicine, Cardiff University, University Hospital of Wales, Cardiff

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Rosalind S. Brown Clinical Trials Research Division of Endocrinology, Children's Hospital Boston, Harvard Medical School, Boston, Mass., USA

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Chantal Daumerie Endocrinologie, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium

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Alicja Hubalewska-Dydejczyk Department of Endocrinology, Jagiellonian University Medical College, Krakow, Poland

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Roberto Negro Division of Endocrinology, V. Fazzi Hospital, Lecce, Italy

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Bijay Vaidya Department of Endocrinology, Royal Devon and Exeter Hospital and University of Exeter Medical School, Exeter, UK

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.2-0.5% in pregnancy and which will not be considered further in this guideline. In children the prevalence of SCH is less than 2% [ 5 ]. When considering SCH, it was agreed that the so-called isolated hypothyroxinaemia as a separate entity should also be

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Victor J M Pop Department of Medical Psychology, Tilburg University, The Netherlands

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Johannes G Krabbe Department of Clinical Chemistry and Laboratory Medicine, Medisch Spectrum Twente, Medlon BV, Enschede, The Netherlands

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Maarten Broeren Department of Clinical Chemistry, Maxima Medical Centre, Veldhoven, The Netherlands

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Wilmar Wiersinga Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands

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Margaret P Rayman Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK

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Introduction In recent decades, a new concept has been defined with regard to thyroid hormone (TH) function during early pregnancy: isolated hypothyroxinaemia (IH) ( 1 , 2 ). This refers to the condition of women with low free thyroxin (FT4

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Nadine Johnson Departments of Obstetrics and Gynaecology, University of the West Indies, Kingston, Jamaica

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Vikash Chatrani Departments of Obstetrics and Gynaecology, University of the West Indies, Kingston, Jamaica

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Anna-Kay Taylor-Christmas Departments of Obstetrics and Gynaecology, University of the West Indies, Kingston, Jamaica

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Eric Choo-Kang Departments of Chemical Pathology, University of the West Indies, Kingston, Jamaica

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Monica Smikle Departments of Microbiology, University of the West Indies, Kingston, Jamaica

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Rosemarie Wright-Pascoe Departments of Medicine, University of the West Indies, Kingston, Jamaica

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Karen Phillips Departments of Medicine, University of the West Indies, Kingston, Jamaica

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Marvin Reid Tropical Metabolism Research Institute, University of the West Indies, Kingston, Jamaica

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hypothyroxinaemia, utilizing the more stringent pregnancy value may identify those subjects with a significantly low FT 4 who may exhibit neuropsychological benefit from L -thyroxine replacement. Treatment of isolated hypothyroxinaemia is currently not recommended

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Stine Linding Andersen Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

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Stig Andersen Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

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function have drawn much attention in pregnant women, specifically. A main focus on maternal T4 in pregnancy emerged before TSH assays were available. With the advancement of assays, the concept of “isolated hypothyroxinemia” emerged. No

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Georgiana Sitoris Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Flora Veltri Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Pierre Kleynen Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Malika Ichiche Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Serge Rozenberg Department of Gynecology and Obstetrics, Centre Hospitalier Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Kris G Poppe Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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.74 mIU/L and subclinical hyperthyroidism was defined as a serum TSH level <0.06 mIU/L together with a normal FT4 level (10.29–18.02 pmol/L), respectively. Isolated hypothyroxinaemia (IH) was defined as an FT4 level <2.5th percentile (10.29 pmol/L) with

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Sophie Demartin Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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Stefan Matei Constantinescu Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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Kris G Poppe Endocrine Unit, Centre Hospitalier Universitaire Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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Dominique Maiter Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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Raluca Maria Furnica Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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Orsalia Alexopoulou Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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Chantal Daumerie Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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Frederic Debiève Department of Obstetrics, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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Maria-Cristina Burlacu Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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Maiter D Bernard P & Daumerie C . First trimester isolated maternal hypothyroxinaemia: adverse maternal metabolic profile and impact on the obstetrical outcome . Clinical Endocrinology 2017 86 576 – 583 . ( https://doi.org/10.1111/cen.13301

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Marta Kostecka-Matyja Chair and Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow

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Anna Fedorowicz Chair and Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow

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Ewa Bar-Andziak Department of Internal Medicine and Endocrinology, Medical University, Warsaw

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Tomasz Bednarczuk Department of Internal Medicine and Endocrinology, Medical University, Warsaw

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Monika Buziak-Bereza Chair and Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow

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Paulina Dumnicka Department of Medical Diagnostics, Jagiellonian University, Collegium Medicum, Krakow

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Maria Górska Department of Endocrinology, Diabetology and Internal Medicine, Medical University, Bialystok

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Małgorzata Krasnodębska Department of Internal Medicine and Endocrinology, Medical University, Warsaw

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Beata Niedźwiedzka Department of Internal Medicine and Endocrinology, Medical University, Warsaw

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Dorota Pach Chair and Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow

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Marek Ruchała Department of Endocrinology, Metabolism and Internal Medicine, University of Medical Sciences, Poznan

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Katarzyna Siewko Department of Endocrinology, Diabetology and Internal Medicine, Medical University, Bialystok

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Bogdan Solnica Department of Diagnostics, Chair of Clinical Biochemistry, Jagiellonian University, Collegium Medicum, Krakow, Poland

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Jerzy Sowiński Department of Endocrinology, Metabolism and Internal Medicine, University of Medical Sciences, Poznan

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Małgorzata Szelachowska Department of Endocrinology, Diabetology and Internal Medicine, Medical University, Bialystok

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Małgorzata Trofimiuk-Müldner Chair and Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow

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Katarzyna Wachowiak-Ochmańska Department of Endocrinology, Metabolism and Internal Medicine, University of Medical Sciences, Poznan

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Alicja Hubalewska-Dydejczyk Chair and Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow

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report that isolated hypothyroxinemia does not affect pregnancy and child development [ 23 , 24 ]. However, there are studies that show hypothyroxinemia, especially in the early stages of pregnancy, is a predictor of lower motor and intellectual

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Barbara A. Demeneix CNRS/UMR7221, Muséum National d’Histoire Naturelle/Université Paris-Sorbonne, Paris, France

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disruption [ 9 , 18 , 19 ]. Another point is that those studies that investigated the effects of T 4 supplementation in women with subclinical hypothyroidism or hypothyroxinaemia on the offspring’s IQ [see, for instance, 20 ] did not take into account

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Flora Veltri Department of Endocrinology, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Kris Poppe Department of Endocrinology, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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unselected group of women consulting for infertility, 5% had isolated positive Tg-Abs, compared with 4% with TPO-Abs only. In the NHANES III study, increased levels of Tg-Abs were not associated with thyroid function compared with increased TPO-Abs [ 11

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Françoise Brucker-Davis Department of Endocrinology, Diabetology and Reproductive Medicine
Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France

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Patricia Panaïa-Ferrari Departments of Biochemistry, UMR U895, Université Nice-Sophia Antipolis, Nice, France

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Jocelyn Gal Departments of Biostatistics, CHU de Nice, UMR U895, Université Nice-Sophia Antipolis, Nice, France

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Patrick Fénichel Department of Endocrinology, Diabetology and Reproductive Medicine
Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France

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Sylvie Hiéronimus Department of Endocrinology, Diabetology and Reproductive Medicine

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isolated maternal hypothyroxinemia with impaired neurocognitive development in the offspring is debated [ 2 , 5 , 6 , 7 ]. Iodine has a central role in the thyroid economy, particularly in pregnancy. Therefore, there are efforts worldwide to eradicate

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