Search for other papers by Luciana Puleo in
Google Scholar
PubMed
Search for other papers by Laura Agate in
Google Scholar
PubMed
Search for other papers by Irene Bargellini in
Google Scholar
PubMed
Search for other papers by Giuseppe Boni in
Google Scholar
PubMed
Search for other papers by Paolo Piaggi in
Google Scholar
PubMed
Search for other papers by Claudio Traino in
Google Scholar
PubMed
Search for other papers by Tommaso Depalo in
Google Scholar
PubMed
Search for other papers by Giulia Lorenzoni in
Google Scholar
PubMed
Search for other papers by Francesca Bianchi in
Google Scholar
PubMed
Search for other papers by Duccio Volterrani in
Google Scholar
PubMed
Search for other papers by Sandra Brogioni in
Google Scholar
PubMed
Search for other papers by Valeria Bottici in
Google Scholar
PubMed
Search for other papers by Maurizia Rossana Brunetto in
Google Scholar
PubMed
Search for other papers by Barbara Coco in
Google Scholar
PubMed
Search for other papers by Eleonora Molinaro in
Google Scholar
PubMed
Search for other papers by Rossella Elisei in
Google Scholar
PubMed
, lungs, bone and more rarely to the skin and brain. Liver metastases occur in 45% of patients with advanced metastatic MTC, and when increasing either in number and/or in size, treatment is indicated ( 5 ). When surgical resection of liver metastases is
Search for other papers by Anne-Sophie Bertrand in
Google Scholar
PubMed
Search for other papers by Antoine Iannessi in
Google Scholar
PubMed
Search for other papers by Isabelle Peyrottes in
Google Scholar
PubMed
Search for other papers by Alexis Lacout in
Google Scholar
PubMed
Search for other papers by Antoine Thyss in
Google Scholar
PubMed
Search for other papers by Pierre-Yves Marcy in
Google Scholar
PubMed
Established Facts Distant tumor spread from differentiated thyroid cancer is rare. The most common metastatic sites include bone and lung. Metastases to brain, eye, breast, liver, kidney, muscle, and skin are infrequent
Search for other papers by Marine Sitbon in
Google Scholar
PubMed
Search for other papers by Porhuoy Chou in
Google Scholar
PubMed
Search for other papers by Seydou Bengaly in
Google Scholar
PubMed
Search for other papers by Brigitte Poirot in
Google Scholar
PubMed
Search for other papers by Marie Laloi-Michelin in
Google Scholar
PubMed
Search for other papers by Laure Deville in
Google Scholar
PubMed
Search for other papers by Atanas Pachev in
Google Scholar
PubMed
Search for other papers by Ahouefa Kowo-Bille in
Google Scholar
PubMed
Search for other papers by Clement Dumont in
Google Scholar
PubMed
Search for other papers by Cécile N Chougnet in
Google Scholar
PubMed
dissection. Cervical recurrences were treated by two supplementary surgeries. Liver metastases, which were slowly progressing since 2008, were treated by radiofrequency ablation in 2015. Bone metastases, which were diagnosed in 2010, were treated by external
Search for other papers by Stéphane Bardet in
Google Scholar
PubMed
Search for other papers by Renaud Ciappuccini in
Google Scholar
PubMed
Search for other papers by Livia Lamartina in
Google Scholar
PubMed
Search for other papers by Sophie Leboulleux in
Google Scholar
PubMed
CEA levels, including smoking, infections, inflammatory bowel disease, pancreatitis, and cirrhosis of the liver. A mild increase in CEA is also observed in benign tumours in the same organs, in which a more pronounced increased level of CEA indicates
Search for other papers by M. Schlumberger in
Google Scholar
PubMed
Search for other papers by L. Bastholt in
Google Scholar
PubMed
Search for other papers by H. Dralle in
Google Scholar
PubMed
Search for other papers by B. Jarzab in
Google Scholar
PubMed
Search for other papers by F. Pacini in
Google Scholar
PubMed
Search for other papers by J.W.A. Smit in
Google Scholar
PubMed
preferably contrast-enhanced MRI of the liver (because liver metastases may be difficult to visualize with CT scan during treatment with antiangiogenic agents), bone scintigraphy and contrast-enhanced MRI of the spine and pelvis [ 6 ]. Fluorodeoxyglucose (FDG
Department of Medicine, Endocrinology Service, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
Search for other papers by Fernanda Andrade in
Google Scholar
PubMed
Search for other papers by Danielle Probstner in
Google Scholar
PubMed
Search for other papers by Marcus Decnop in
Google Scholar
PubMed
Search for other papers by Daniel Bulzico in
Google Scholar
PubMed
Search for other papers by Denise Momesso in
Google Scholar
PubMed
Department of Medicine, Endocrinology Service, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
Search for other papers by Rossana Corbo in
Google Scholar
PubMed
Search for other papers by Mario Vaisman in
Google Scholar
PubMed
Department of Medicine, Endocrinology Service, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
Search for other papers by Fernanda Vaisman in
Google Scholar
PubMed
-related osteonecrosis of the jaw (BRONJ) or atypical fracture. Finally, in terms of disease-related death (Table 4 ), statistical analysis revealed the presence of concomitant metastases in the brain ( p = 0.03), liver ( p = 0.05), and the presence of bone
College of Medicine, Yonsei University, Seoul, Republic of Korea
Search for other papers by Jihwan Yoo in
Google Scholar
PubMed
Search for other papers by Hee Jun Kim in
Google Scholar
PubMed
Search for other papers by Seok Mo Kim in
Google Scholar
PubMed
Search for other papers by Hun Ho Park in
Google Scholar
PubMed
(RAI) therapy, tyrosine kinase inhibitor (TKI), or radiotherapy), coexisting distant metastases and their location, and radiologic characteristics of brain metastasis observed on brain MRI (maximum diameter, multiplicity, intratumoral hemorrhage, and
Search for other papers by Ana Piñar-Gutiérrez in
Google Scholar
PubMed
Search for other papers by Ana R Romero-Lluch in
Google Scholar
PubMed
Search for other papers by Suset Dueñas-Disotuar in
Google Scholar
PubMed
Search for other papers by Irene de Lara-Rodríguez in
Google Scholar
PubMed
Search for other papers by María Ángeles Gálvez-Moreno in
Google Scholar
PubMed
Search for other papers by Tomás Martín-Hernández in
Google Scholar
PubMed
Search for other papers by Jorge García-Alemán in
Google Scholar
PubMed
Search for other papers by Guillermo Martínez-de Pinillos in
Google Scholar
PubMed
Search for other papers by Elena Navarro-González in
Google Scholar
PubMed
metastases in other locations (lung, brain, mediastinum, adrenal glands and liver), treatments performed (antiresorptives, corticosteroids, I131 – including doses before and after BM diagnosis and uptake by BM – radiotherapy, surgery and TKIs) and their
Search for other papers by Francesca Orsolini in
Google Scholar
PubMed
Search for other papers by Alessandro Prete in
Google Scholar
PubMed
Search for other papers by Pierpaolo Falcetta in
Google Scholar
PubMed
Search for other papers by Domenico Canale in
Google Scholar
PubMed
Search for other papers by Fulvio Basolo in
Google Scholar
PubMed
Search for other papers by Greta Alì in
Google Scholar
PubMed
Search for other papers by Francesca Manassero in
Google Scholar
PubMed
Search for other papers by Paolo Vitti in
Google Scholar
PubMed
Search for other papers by Rossella Elisei in
Google Scholar
PubMed
Search for other papers by Eleonora Molinaro in
Google Scholar
PubMed
( 2 , 3 , 5 ). Other than to the soft tissues of the neck region, MTC spreads first to the liver (45%) and bone (45%) and less commonly to lung (33%), brain (1–5%) or skin (few cases reported) ( 6 ). Metastases to adrenal glands, pleura, heart, ovary
UMR9019, Genome Integrity and Cancers, CNRS, Villejuif, France
Search for other papers by Camille Buffet in
Google Scholar
PubMed
Search for other papers by Sophie Leboulleux in
Google Scholar
PubMed
CHU Nantes/ICO, Saint-Herblain, France
Search for other papers by Françoise Kraeber-Bodéré in
Google Scholar
PubMed
CHU Nantes/ICO, Saint-Herblain, France
Search for other papers by Caroline Bodet-Milin in
Google Scholar
PubMed
Université de Paris, Paris, France
Search for other papers by Laure Cabanes in
Google Scholar
PubMed
Department of Radiology, AP-HP, Hôpital Cochin, Paris, France
Search for other papers by Anthony Dohan in
Google Scholar
PubMed
Search for other papers by Pascal Leprince in
Google Scholar
PubMed
Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy Institute, Villejuif, France
Search for other papers by Martin Schlumberger in
Google Scholar
PubMed
Department of Medical Oncology, AP-HP, Hôpital Cochin, Paris, France
Search for other papers by Olivier Huillard in
Google Scholar
PubMed
Université de Paris, Paris, France
Department of Endocrinology, AP-HP, Hôpital Cochin, Paris, France
Search for other papers by Lionel Groussin in
Google Scholar
PubMed
/mL and 14.5 ng/mL, respectively). A chest CT showed micronodular lung and liver metastases and a suspicious 65-mm myocardial mass in the right atrioventricular groove invading the pericardium, the ipsilateral atrial and ventricular cavities, and the