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Tommaso Piticchio Endocrinology Section, Department of Clinical and Experimental Medicine, Garibaldi Nesima Hospital, University of Catania, Catania, Italy
Servizio di Endocrinologia e Diabetologia, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland

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Gilles Russ Department of Thyroid and Endocrine Tumor Diseases, La Pitie-Salpetriere Hospital, 83 Bd de l’Hopital, Paris, France

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Maija Radzina Riga Stradins University, Radiology Research Laboratory, Riga, Latvia
University of Latvia, Faculty of Medicine, Riga, Latvia

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Francesco Frasca Endocrinology Section, Department of Clinical and Experimental Medicine, Garibaldi Nesima Hospital, University of Catania, Catania, Italy

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Cosimo Durante Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

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Pierpaolo Trimboli Servizio di Endocrinologia e Diabetologia, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
Facoltà di Scienze Biomediche, Università della Svizzera Italiana (USI), Lugano, Switzerland

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). Considering the epidemiological figures and potential oncological implications, international guidelines recommend an immediate malignancy risk assessment for newly diagnosed TNs, and ultrasound (US) is universally recognized as the first-line diagnostic

Article Type:
Review Article
Collections:
Goiter and thyroid nodules
DOI:
https://doi.org/10.1530/ETJ-23-0242
Volume/Issue:
Volume 13: Issue 2
Open access
Diana Borges Duarte Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal

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Vânia Benido Silva Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal

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Guilherme Assunção Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal

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André Couto Carvalho Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal

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Cláudia Freitas Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal

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Introduction Differentiated thyroid carcinoma (DTC) is the most common endocrine gland malignancy, most frequently diagnosed among women between the ages of 45 and 54 years ( 1 , 2 ). Despite the increasing incidence worldwide over the last

Article Type:
Research Article
Collections:
Thyroid cancer - clinical
DOI:
https://doi.org/10.1530/ETJ-22-0018
Volume/Issue:
Volume 11: Issue 4
Open access
Bülent Öcal Department of Otolaryngology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

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Mehmet Hakan Korkmaz Department of Otolaryngology, Yıldırım Beyazıt University Medical School, Ankara, Turkey

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Demet Yılmazer Department of Pathology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

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Tuğba Taşkın Türkmenoğlu Department of Pathology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

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Ömer Bayır Department of Otolaryngology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

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Güleser Saylam Department of Otolaryngology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

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Emel Çadallı Tatar Department of Otolaryngology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

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Sevilay Karahan Department of Biostatistics, Faculty of Medicine, Hacettepe University, Ankara, Turkey

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Erman Çakal Department of Endocrinology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

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Introduction The estimated prevalence of thyroid nodules in an adult population is 4–7% by palpation and 10–41% by ultrasound (US) scanning [ 1 , 2 ]. The overall malignancy risk, regardless of nodule size, is < 10%, and even smaller nodules

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000494720
Volume/Issue:
Volume 8: Issue 2
Free access
M Grussendorf Department of Internal Medicine, University Hospital, Düsseldorf, Germany

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I Ruschenburg MVZ Wagnerstibbe Center for Cytology and Pathology, Einbeck, Germany

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G Brabant Department of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, University of Manchester, Manchester, UK

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population can be expected ( 3 , 5 , 6 ). If we base the rate of malignancy (ROM) of these nodules on data from current guidelines, between 7 and 15% of the nodules bear a malignancy ( 7 , 8 ). As these data mainly reflect nodules suspected on the basis of

Article Type:
Research Article
Collections:
Goiter and thyroid nodules
DOI:
https://doi.org/10.1530/ETJ-22-0027
Volume/Issue:
Volume 11: Issue 4
Open access
Ana Isabel Álvarez-Mancha Department of Medicine, University of Malaga, Malaga, Spain
Department of Pathology, General University Hospital of Ciudad Real, Ciudad Real, Spain

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Isabel Mancha-Doblas Department of Medicine, University of Malaga, Malaga, Spain
Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Málaga, Spain

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María Molina-Vega Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Málaga, Spain
The Biomedical Research Institute of Malaga and Platform in Nanomedicine (IBIMA-BIONAND Platform), University of Malaga, Malaga, Spain

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Diego Fernández-García Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Málaga, Spain

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Ana María Gómez-Pérez Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Málaga, Spain
The Biomedical Research Institute of Malaga and Platform in Nanomedicine (IBIMA-BIONAND Platform), University of Malaga, Malaga, Spain

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Elena Gallego-Domínguez Department of Medicine, University of Malaga, Malaga, Spain
Department of Pathology, Virgen de la Victoria University Hospital, Málaga, Spain

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María Victoria Ortega-Jiménez Department of Medicine, University of Malaga, Malaga, Spain
Department of Pathology, Virgen de la Victoria University Hospital, Málaga, Spain

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Isabel Hierro-Martín Department of Pathology, Virgen de la Victoria University Hospital, Málaga, Spain

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Francisco J Tinahones Department of Medicine, University of Malaga, Malaga, Spain
Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Málaga, Spain
The Biomedical Research Institute of Malaga and Platform in Nanomedicine (IBIMA-BIONAND Platform), University of Malaga, Malaga, Spain

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, 6 , 7 , 8 , 9 ). A cytological diagnosis carries a certain risk of malignancy (ROM), which has implications for clinical recommendations. While FNA is an efficient and cost-effective diagnostic procedure, it is important to note that histological

Article Type:
Research Article
Collections:
Goiter and thyroid nodules
DOI:
https://doi.org/10.1530/ETJ-24-0076
Volume/Issue:
Volume 13: Issue 3
Open access
Gilles Russ Thyroid and Endocrine Tumors, Institute of Endocrinology, Pitié Salpêtrière Hospital, Pierre and Marie Curie University, Paris, France

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Steen J. Bonnema Department of Endocrinology, Odense University Hospital, Odense, Denmark

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Murat Faik Erdogan Department of Endocrinology and Metabolism, University of Ankara School of Medicine, İbni Sina Hastanesi, Ankara, Turkey

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Cosimo Durante Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy

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Rose Ngu Head Neck and Thyroid Imaging, Department of Radiology, Guy’s and St Thomas’ Hospitals NHS Foundation Trust, London, United Kingdom

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Laurence Leenhardt Thyroid and Endocrine Tumors, Institute of Endocrinology, Pitié Salpêtrière Hospital, Pierre and Marie Curie University, Paris, France

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clinical parameters, indications for FNA should be based on ultrasonographic malignancy risk stratification alongside clinical risk factors. Accuracy of Thyroid Ultrasound Features Certain features of thyroid nodules on ultrasound (US) are

Article Type:
Guideline
DOI:
https://doi.org/10.1159/000478927
Volume/Issue:
Volume 6: Issue 5
Free access
Aglaia Kyrilli Department of Endocrinology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium

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Nunzia Tacelli Department of Radiology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium

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Lucia Russo Department of Medicine, DIMED, Internal Medicine 3, University of Padua, Via Giustiniani 2, 35128, Padova, Italy

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Laetitia Lebrun Department of Pathology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium

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Isabelle Salmon Department of Pathology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium

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Gilles Russ Thyroid and Endocrine Tumors, Institute of Endocrinology, Pitié Salpêtrière Hospital, Pierre et Marie Curie University, Paris, France

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Rodrigo Moreno-Reyes Department of Nuclear Medicine, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik, Brussels, Belgium

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Bernard Corvilain Department of Endocrinology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium

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(US), the first-line tool to stratify malignancy risk of thyroid nodules, does not, unlike scintigraphy, evaluate the nodule’s functional characteristics. The utility to effectively diagnose AFTN relies on the generally admitted assumption that AFTN

Article Type:
Research Article
Collections:
Goiter and thyroid nodules
DOI:
https://doi.org/10.1530/ETJ-23-0135
Volume/Issue:
Volume 12: Issue 6
Open access
Mohamed Abdouh Cancer Research Program, McGill University Health Centre-Research Institute, Montreal, Québec, Canada

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Roger Tabah Department of Surgery and Department of Oncology, McGill University Health Centre, Montreal, Québec, Canada

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Vincenzo Arena Department of Obstetrics and Gynecology, Santo Bambino Hospital, Catania, Italy

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Manuel Arena Fondazione Istituto G. Giglio Cefalù, Pisciotto, Italy

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Zu-hua Gao Department of Pathology, McGill University Health Centre-Research Institute, Montreal, Québec, Canada

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Aurelio Lorico College of Medicine, Touro University Nevada, Henderson, Nevada, USA
Istituto Oncologico del Mediterraneo, Viagrande, Italy

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Goffredo Orazio Arena Fondazione Istituto G. Giglio Cefalù, Pisciotto, Italy
Istituto Oncologico del Mediterraneo, Viagrande, Italy
Department of Surgery, McGill University, St. Mary Hospital, Montreal, Québec, Canada

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Introduction Masses arising in the glands of the head and the neck regions are often seen in clinical practice, and the first priority is to determine whether they are benign or malignant. Malignancies of the head glands such as salivary

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000516421
Volume/Issue:
Volume 10: Issue 4
Free access
Signe Buhl Gram Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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Jacob Høygaard Rasmussen Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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Ulla Feldt-Rasmussen Department of Medical Endocrinology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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Jens Bentzen Department of Oncology, Herlev Hospital, Copenhagen University, Copenhagen, Denmark

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Giedrius Lelkaitis Department of Pathology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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Christian von Buchwald Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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Christoffer Holst Hahn Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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Introduction Thyroid carcinoma is the most common endocrine malignancy. Two Danish studies report an incidence of 1.57 cases per 100,000 men, 4.11 cases per 100,000 women [ 1 ], and 4.5 cases per 100,000 men and women [ 2 ]. With a rapidly

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000500539
Volume/Issue:
Volume 8: Issue 5
Free access
Catherine Brophy Departments of Otolaryngology - Head and Neck Surgery, Cork, Ireland

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Rania Mehanna Departments of Otolaryngology - Head and Neck Surgery, Cork, Ireland

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Julie McCarthy Departments of Cytopathology, Cork University Hospital, Cork, Ireland

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Antoinette Tuthill Departments of Endocrinology, Cork University Hospital, Cork, Ireland

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Matthew S. Murphy Departments of Endocrinology, South Infirmary Victoria University Hospital, Cork, Ireland

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Patrick Sheahan Departments of Otolaryngology - Head and Neck Surgery, Cork, Ireland

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clinically apparent thyroid nodules is between 5 and 15% [ 2 ]. Fine-needle aspiration (FNA) cytology has demonstrated high utility in the diagnosis of thyroid nodules. In an effort to stratify thyroid nodules according to risk of malignancy in a consistent

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000441221
Volume/Issue:
Volume 4: Issue 4
Free access