Filter

Refine by date

—

Refine by collections

  • Print
  • Save

Search Results

You are looking at 1 - 10 of 15 items for :

Clear All
Mohammad-Reza Mahmoudian-sani Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Department of Genetics and Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Search for other papers by Mohammad-Reza Mahmoudian-sani in
Google Scholar
PubMed Close
,
Ameneh Mehri-Ghahfarrokhi Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

Search for other papers by Ameneh Mehri-Ghahfarrokhi in
Google Scholar
PubMed Close
,
Majid Asadi-Samani Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran

Search for other papers by Majid Asadi-Samani in
Google Scholar
PubMed Close
, and
Gholam-Reza Mobini Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

Search for other papers by Gholam-Reza Mobini in
Google Scholar
PubMed Close

long-term surveillance for 25% of patients due to the presence of thyroglobulin antibody. In FNA-aspirated cells, about 30% of thyroid gland biopsies remain undecided or undiagnosed [ 6 ]. Tumors of molecular markers such as miRNA are generated by

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000468520
Volume/Issue:
Volume 6: Issue 4
Free access
Joanna Bogusławska Centre of Postgraduate Medical Education, Department of Biochemistry and Molecular Biology, Warsaw, Poland

Search for other papers by Joanna Bogusławska in
Google Scholar
PubMed Close
,
Marlena Godlewska Centre of Postgraduate Medical Education, Department of Biochemistry and Molecular Biology, Warsaw, Poland

Search for other papers by Marlena Godlewska in
Google Scholar
PubMed Close
,
Ewa Gajda Centre of Postgraduate Medical Education, Department of Biochemistry and Molecular Biology, Warsaw, Poland

Search for other papers by Ewa Gajda in
Google Scholar
PubMed Close
, and
Agnieszka Piekiełko-Witkowska Centre of Postgraduate Medical Education, Department of Biochemistry and Molecular Biology, Warsaw, Poland

Search for other papers by Agnieszka Piekiełko-Witkowska in
Google Scholar
PubMed Close

depending on their length into long ncRNAs (lncRNAs) and short ncRNAs (e.g. miRNA, piRNAs). Based on their function, ncRNAs are classified into infrastructural (e.g. snRNA, snoRNAs, and rRNAs) and regulatory ncRNAs (e.g. miRNA, lncRNAs, piRNAs, and siRNAs

Article Type:
Review Article
Collections:
Thyroid autoimmunity
DOI:
https://doi.org/10.1530/ETJ-21-0024
Volume/Issue:
Volume 11: Issue 1
Open access
Vincenza Leone Istituto di Endocrinologia ed Oncologia Sperimentale-CNR, Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Scuola di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II', Naples, Italy

Search for other papers by Vincenza Leone in
Google Scholar
PubMed Close
,
Concetta Langella Istituto di Endocrinologia ed Oncologia Sperimentale-CNR, Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Scuola di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II', Naples, Italy

Search for other papers by Concetta Langella in
Google Scholar
PubMed Close
,
Francesco Esposito Istituto di Endocrinologia ed Oncologia Sperimentale-CNR, Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Scuola di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II', Naples, Italy

Search for other papers by Francesco Esposito in
Google Scholar
PubMed Close
,
Marco De Martino Istituto di Endocrinologia ed Oncologia Sperimentale-CNR, Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Scuola di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II', Naples, Italy

Search for other papers by Marco De Martino in
Google Scholar
PubMed Close
,
Myriam Decaussin-Petrucci Department of Pathology, Lyon Sud Hospital Center, Hospices Civils de Lyon, Lyon, France

Search for other papers by Myriam Decaussin-Petrucci in
Google Scholar
PubMed Close
,
Gennaro Chiappetta Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione Giovanni Pascale', IRCCS, Naples, Italy

Search for other papers by Gennaro Chiappetta in
Google Scholar
PubMed Close
,
Antonio Bianco Dipartimento di Sanità Pubblica, Università di Napoli Federico II, Naples, Italy

Search for other papers by Antonio Bianco in
Google Scholar
PubMed Close
, and
Alfredo Fusco Istituto di Endocrinologia ed Oncologia Sperimentale-CNR, Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Scuola di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II', Naples, Italy
Instituto Nacional de Cancer (INCA), Rio de Janeiro, Brazil

Search for other papers by Alfredo Fusco in
Google Scholar
PubMed Close

Introduction MicroRNAs (miRNAs) are small noncoding RNA molecules of 19-22 nucleotides in length that are capable of regulating gene expression at a translational level and binding to a complementary sequence found in the 3′-untranslated

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000441355
Volume/Issue:
Volume 4: Issue 4
Free access
Rob Janssen Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands

Search for other papers by Rob Janssen in
Google Scholar
PubMed Close
,
Alice Muller Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands

Search for other papers by Alice Muller in
Google Scholar
PubMed Close
, and
Warner S. Simonides Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands

Search for other papers by Warner S. Simonides in
Google Scholar
PubMed Close

physiological and/or pathological cardiac remodeling [ 1 , 3 ]. Stimulation and repression of gene expression are the result of direct transcriptional effects as well as regulation of translation efficiency by microRNAs (miRNAs) [ 4 , 5 ]. In the case of

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000469708
Volume/Issue:
Volume 6: Issue 3
Open access
Jacopo Manso Department of Medicine (DIMED), Endocrinology Unit, University of Padua, Padua, Italy
Department of Women’s and Children’s Health, Pediatric Endocrinology Unit, Padua University Hospital, Padua, Italy

Search for other papers by Jacopo Manso in
Google Scholar
PubMed Close
,
Simona Censi Department of Medicine (DIMED), Endocrinology Unit, University of Padua, Padua, Italy

Search for other papers by Simona Censi in
Google Scholar
PubMed Close
,
Cristina Clausi Department of Medicine (DIMED), Endocrinology Unit, University of Padua, Padua, Italy

Search for other papers by Cristina Clausi in
Google Scholar
PubMed Close
,
Ilaria Piva Department of Medicine (DIMED), Endocrinology Unit, University of Padua, Padua, Italy

Search for other papers by Ilaria Piva in
Google Scholar
PubMed Close
,
Yi Hang Zhu Department of Medicine (DIMED), Endocrinology Unit, University of Padua, Padua, Italy

Search for other papers by Yi Hang Zhu in
Google Scholar
PubMed Close
,
Alberto Mondin Department of Medicine (DIMED), Endocrinology Unit, University of Padua, Padua, Italy

Search for other papers by Alberto Mondin in
Google Scholar
PubMed Close
,
Maria Chiara Pedron Department of Medicine (DIMED), Endocrinology Unit, University of Padua, Padua, Italy

Search for other papers by Maria Chiara Pedron in
Google Scholar
PubMed Close
,
Susi Barollo Department of Medicine (DIMED), Endocrinology Unit, University of Padua, Padua, Italy

Search for other papers by Susi Barollo in
Google Scholar
PubMed Close
,
Loris Bertazza Department of Medicine (DIMED), Endocrinology Unit, University of Padua, Padua, Italy

Search for other papers by Loris Bertazza in
Google Scholar
PubMed Close
,
Giulia Midena Department of Molecular Medicine, University of Padua, Padua, Italy

Search for other papers by Giulia Midena in
Google Scholar
PubMed Close
,
Raffaele Parrozzani Department of Ophthalmology, University of Padua, Padua, Italy

Search for other papers by Raffaele Parrozzani in
Google Scholar
PubMed Close
, and
Caterina Mian Department of Medicine (DIMED), Endocrinology Unit, University of Padua, Padua, Italy

Search for other papers by Caterina Mian in
Google Scholar
PubMed Close

immunosuppressive treatment is between 50 and 80% according to published trials ( 7 ). For this reason, where first-line GC therapies fail, other second-line treatments are available, such as rituximab, tocilizumab or teprotumumab (only in the USA). miRNAs are

Article Type:
Research Article
Collections:
Thyroid autoimmunity
DOI:
https://doi.org/10.1530/ETJ-23-0083
Volume/Issue:
Volume 12: Issue 5
Open access
Alison-Michelle Naujack A Naujack, Department of Epigenetics and Metabolism, University of Lübeck, Lubeck, Germany

Search for other papers by Alison-Michelle Naujack in
Google Scholar
PubMed Close
,
Christin Krause C Krause, Department of Epigenetics and Metabolism, University of Lübeck, Lubeck, Germany

Search for other papers by Christin Krause in
Google Scholar
PubMed Close
,
Jan H. Britsemmer J Britsemmer, Department of Epigenetics and Metabolism, University of Lübeck, Lubeck, Germany

Search for other papers by Jan H. Britsemmer in
Google Scholar
PubMed Close
,
Natalie Taege N Taege, Department of Epigenetics and Metabolism, University of Lübeck, Lubeck, Germany

Search for other papers by Natalie Taege in
Google Scholar
PubMed Close
,
Jens Mittag J Mittag, Institute for Experimental Endocrinology, Universitzy of Lübeck, Lübeck, Germany

Search for other papers by Jens Mittag in
Google Scholar
PubMed Close
, and
Henriette Kirchner H Kirchner, Department of Epigenetics and Metabolism, University of Lübeck, Lubeck, Germany

Search for other papers by Henriette Kirchner in
Google Scholar
PubMed Close

Objective: Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by inflammation, fibrosis and accumulation of fatty acids in the liver. MASH disease progression has been associated with reduced thyroid hormone (TH) signalling in the liver, including reduced expression of deiodinase type I (DIO1) and TH receptor beta (THRB). However, the underlying mechanisms mediating these effects remain elusive. Here, we hypothesized, that epigenetic mechanisms may be involved in modulating hepatic TH action.

Methods: Liver samples from patients with and without MASH were analyzed by qRT-PCR and correlated with clinical parameters. Luciferase reporter assays and overexpression of miRNA in HepG2-cells were used to validate functional binding of miRNA to predicted targets. DNA-methylation was analyzed by bisulfite-pyrosequencing.

Results: miR-34a-5p was upregulated in MASH patients and correlated positively with clinical parameters of MASH. Using in silico and in vitro analysis we demonstrate that miR-34a-5p is capable of targeting several modulators of local hepatic TH action, as evidenced by functional binding of miR-34a-5p to the seed sequence in the THRB and DIO1 genes. Consequently, overexpression of miR-34a-5p in HepG2-cells reduced the expression of THRA, THRB, DIO1 and SLC10A1, thus potentially mediating an acquired hepatic resistance to TH in MASH. As additional regulatory mechanism, DNA-methylation of THRB intron 1 was increased in MASH and negatively correlated with THRB expression.

Conclusion: miR-34a-5p constitutes a possible epigenetic master regulator of hepatic TH action, which together with THRB specific DNA-methylation could explain a possible developing TH resistance in the liver during MASH progression on the molecular level.

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ETJ-24-0080
Volume/Issue:
Accepted Manuscripts
Open access
Carles Zafon Department of Endocrinology, Hospital Vall d'Hebron, and Diabetes and Metabolism Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona and CIBERDEM (ISCIII), Barcelona

Search for other papers by Carles Zafon in
Google Scholar
PubMed Close
,
Juan J. Díez Department of Endocrinology and Nutrition, Hospital Ramón y Cajal
Department of Medicine, University of Alcalá de Henares, Madrid

Search for other papers by Juan J. Díez in
Google Scholar
PubMed Close
,
Juan C. Galofré Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain
IdiSNA (Instituto de investigación en la salud de Navarra), Pamplona, Spain

Search for other papers by Juan C. Galofré in
Google Scholar
PubMed Close
, and
David S. Cooper Division of Endocrinology, Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Search for other papers by David S. Cooper in
Google Scholar
PubMed Close

-related mutations. The ThyroSeq approach has been proposed as a “rule-in” test [ 16 , 17 , 18 ], that is, a test with a high specificity. - Rossetta genomics is a platform recently developed that analyses the expression of a combination of micro-RNA (miRNA

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000457793
Volume/Issue:
Volume 6: Issue 2
Free access
Ralf Paschke
Search for other papers by Ralf Paschke in
Google Scholar
PubMed Close
,
Silvia Cantara
Search for other papers by Silvia Cantara in
Google Scholar
PubMed Close
,
Anna Crescenzi
Search for other papers by Anna Crescenzi in
Google Scholar
PubMed Close
,
Barbara Jarzab
Search for other papers by Barbara Jarzab in
Google Scholar
PubMed Close
,
Thomas J. Musholt
Search for other papers by Thomas J. Musholt in
Google Scholar
PubMed Close
, and
Manuel Sobrinho Simoes
Search for other papers by Manuel Sobrinho Simoes in
Google Scholar
PubMed Close

], targeted next-generation sequencing (tNGS) [ 12 ], and the combination of mutation detection and miRNA expression [ 13 ], have been reported as promising in ruling in or out a substantial risk of cancer. Of note, the major limit to the use of molecular

Article Type:
Guideline
DOI:
https://doi.org/10.1159/000468519
Volume/Issue:
Volume 6: Issue 3
Free access
Giulia Brigante Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria, Modena, Italy

Search for other papers by Giulia Brigante in
Google Scholar
PubMed Close
,
Clara Lazzaretti Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

Search for other papers by Clara Lazzaretti in
Google Scholar
PubMed Close
,
Elia Paradiso Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

Search for other papers by Elia Paradiso in
Google Scholar
PubMed Close
,
Federico Nuzzo Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

Search for other papers by Federico Nuzzo in
Google Scholar
PubMed Close
,
Martina Sitti Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

Search for other papers by Martina Sitti in
Google Scholar
PubMed Close
,
Frank Tüttelmann Institute of Reproductive Genetics, University of Münster, Münster, Germany

Search for other papers by Frank Tüttelmann in
Google Scholar
PubMed Close
,
Gabriele Moretti Department of Biology, University of Pisa, Pisa, Italy

Search for other papers by Gabriele Moretti in
Google Scholar
PubMed Close
,
Roberto Silvestri Department of Biology, University of Pisa, Pisa, Italy

Search for other papers by Roberto Silvestri in
Google Scholar
PubMed Close
,
Federica Gemignani Department of Biology, University of Pisa, Pisa, Italy

Search for other papers by Federica Gemignani in
Google Scholar
PubMed Close
,
Asta Försti Hopp Children’s Cancer Center (KiTZ), Heidelberg, Germany
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany

Search for other papers by Asta Försti in
Google Scholar
PubMed Close
,
Kari Hemminki Biomedical Center, Faculty of Medicine and Biomedical Center in Pilsen, Charles University in Prague, Pilsen, Czech Republic
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Search for other papers by Kari Hemminki in
Google Scholar
PubMed Close
,
Rossella Elisei Department of Endocrinology, University Hospital, Pisa, Italy

Search for other papers by Rossella Elisei in
Google Scholar
PubMed Close
,
Cristina Romei Department of Endocrinology, University Hospital, Pisa, Italy

Search for other papers by Cristina Romei in
Google Scholar
PubMed Close
,
Eric Adriano Zizzi PolitoBIO Med Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Italy

Search for other papers by Eric Adriano Zizzi in
Google Scholar
PubMed Close
,
Marco Agostino Deriu PolitoBIO Med Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Italy

Search for other papers by Marco Agostino Deriu in
Google Scholar
PubMed Close
,
Manuela Simoni Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria, Modena, Italy
Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy

Search for other papers by Manuela Simoni in
Google Scholar
PubMed Close
,
Stefano Landi Department of Biology, University of Pisa, Pisa, Italy

Search for other papers by Stefano Landi in
Google Scholar
PubMed Close
, and
Livio Casarini Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy

Search for other papers by Livio Casarini in
Google Scholar
PubMed Close

of Let-7 and risk of papillary thyroid carcinoma: a case-control study . Medicine 2015 94 e1879. ( https://doi.org/10.1097/MD.0000000000001879 ) 58 Perdas E Stawski R Kaczka K Zubrzycka M . Analysis of Let-7 family miRNA in plasma as

Article Type:
Research Article
Collections:
Genetics and omics in thyroidology
DOI:
https://doi.org/10.1530/ETJ-22-0058
Volume/Issue:
Volume 11: Issue 5
Open access
Dorothée Bouron-Dal Soglio Department of Pathology, CHU Sainte-Justine, Montreal, Québec, Canada

Search for other papers by Dorothée Bouron-Dal Soglio in
Google Scholar
PubMed Close
,
Leanne de Kock The Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, Québec, Canada
Department of Human Genetics, McGill University, Montreal, Québec, Canada

Search for other papers by Leanne de Kock in
Google Scholar
PubMed Close
,
Richard Gauci Nuclear Medicine, Sir Charles Gairdner Hospital, Nedlands, Washington, Australia

Search for other papers by Richard Gauci in
Google Scholar
PubMed Close
,
Nelly Sabbaghian The Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, Québec, Canada

Search for other papers by Nelly Sabbaghian in
Google Scholar
PubMed Close
,
Elizabeth Thomas Nuclear Medicine, Sir Charles Gairdner Hospital, Nedlands, Washington, Australia
Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Subiaco, Washington, Australia

Search for other papers by Elizabeth Thomas in
Google Scholar
PubMed Close
,
Helen C. Atkinson Faculty of Health and Medical Sciences, School of Medicine, The University of Western Australia, Crawley, Washington, Australia

Search for other papers by Helen C. Atkinson in
Google Scholar
PubMed Close
,
Nicholas Pachter Faculty of Health and Medical Sciences, School of Medicine, The University of Western Australia, Crawley, Washington, Australia
King Edward Memorial Hospital, Perth, Washington, Australia

Search for other papers by Nicholas Pachter in
Google Scholar
PubMed Close
,
Simon Ryan Department of General Surgery, Sir Charles Gairdner Hospital, Nedlands, Washington, Australia

Search for other papers by Simon Ryan in
Google Scholar
PubMed Close
,
John P. Walsh Faculty of Health and Medical Sciences, School of Medicine, The University of Western Australia, Crawley, Washington, Australia
Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Washington, Australia

Search for other papers by John P. Walsh in
Google Scholar
PubMed Close
,
M. Priyanthi Kumarasinghe PathWest, QEII Medical Centre, Perth, Washington, Australia

Search for other papers by M. Priyanthi Kumarasinghe in
Google Scholar
PubMed Close
,
Karen Carpenter Department of Diagnostic Genomics, PathWest Laboratory Medicine, QEII Medical Centre, Nedlands, Washington, Australia

Search for other papers by Karen Carpenter in
Google Scholar
PubMed Close
,
Ayça Aydoğan Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey

Search for other papers by Ayça Aydoğan in
Google Scholar
PubMed Close
,
Colin J.R. Stewart King Edward Memorial Hospital, Perth, Washington, Australia

Search for other papers by Colin J.R. Stewart in
Google Scholar
PubMed Close
,
William D. Foulkes The Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, Québec, Canada
Department of Human Genetics, McGill University, Montreal, Québec, Canada
Department of Medical Genetics, Research Institute of the McGill University Health Centre, Montreal, Québec, Canada

Search for other papers by William D. Foulkes in
Google Scholar
PubMed Close
, and
Catherine S. Choong Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Subiaco, Washington, Australia
Faculty of Health and Medical Sciences, School of Medicine, The University of Western Australia, Crawley, Washington, Australia

Search for other papers by Catherine S. Choong in
Google Scholar
PubMed Close

precursors to generate mature microRNAs (miRNAs), which, in turn, post-transcriptionally regulate gene expression. Carriers of DICER1 mutations are predisposed to developing a broad range of tumours of predominantly paediatric or adolescent onset [ 17 ], as

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000481620
Volume/Issue:
Volume 7: Issue 1
Free access