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Inês Cosme Department of Endocrinology, Unidade Local de Saúde Santa Maria, Lisbon, Portugal

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Ana Figueiredo Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Sara Pinheiro Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Valeriano Leite Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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study was to compare demographic, clinical, and histological data, pTNM classification and staging, radioactive iodine (RAI) treatment, postoperative thyroglobulin levels, and 5-year prognosis between incidental TC (ITC) and non-incidental TC (NITC

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Lan Wu State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

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Salvatore Vaccarella International Agency for Research on Cancer (IARC/WHO), Lyon, France

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Chen-Yang Feng Information Technology Center, Sun Yat-sen University Cancer Center, Guangzhou, China

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Luigino Dal Maso Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy

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Yu Chen State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

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Wei-Wei Liu Department of Head and Neck, Sun Yat-sen University Cancer Center, Guangzhou, China

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Miao-Bian Liang State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

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Zike Zhang Department of Laboratory Medicine, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China

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Jun Yang School of Public Health, Guangzhou Medical University, Guangzhou, China

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Su-Mei Cao State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

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Mengmeng Li State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

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categorized into incidental and non-incidental detection ( 6 ). Medical records were reviewed to identify the route of detection: if the detection of thyroid cancer was due to investigations/follow-up for conditions unrelated to the thyroid or through health

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Rosa M. García-Moreno Endocrinology and Nutrition Department, Hospital Universitario La Paz, Madrid, Spain

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Cristina Escabias Nuclear Medicine Department, Hospital Universitario La Paz, Madrid, Spain

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Cristina Utrilla Radiology Department, Hospital Universitario La Paz, Madrid, Spain

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Elena Ruiz-Bravo Pathology Department, Hospital Universitario La Paz, Madrid, Spain

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Margarita Sánchez Ophthalmology Department, Hospital Universitario La Paz, Madrid, Spain

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Beatriz Lecumberri Endocrinology and Nutrition Department, Hospital Universitario La Paz, Madrid, Spain

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incidental radioiodine uptake in the orbital region. Introduction Differentiated thyroid cancer is one of the most prevalent solid tumor types with a rising incidence, and papillary thyroid carcinoma (PTC) represents the most frequent variant [ 1

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Fahim U. Hassan Nuclear Medicine Department, Borough Wing, Guy's Hospital, London, UK

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Hosahalli K. Mohan Nuclear Medicine Department, Borough Wing, Guy's Hospital, London, UK

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that were at risk of pathological fracture in these patients. SPECT/CT was particularly useful for the assessment of non-radioiodine avid disease in patients where planar scintigraphy was negative. Incidental significant pathologies were also identified

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F. Cecoli Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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E.M. Ceresola Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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V. Altrinetti Endocrinology and Nuclear Medicine, Galliera Hospital, Genoa

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M. Cabria Endocrinology and Nuclear Medicine, Galliera Hospital, Genoa

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M. Cappagli Endocrine Unit, Sant'Andrea Hospital, La Spezia

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A. Montepagani Endocrine Unit, Sant'Andrea Hospital, La Spezia

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C.M. Cuttica Endocrinology and Nuclear Medicine, Galliera Hospital, Genoa

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U. Filippi Evangelico Internazionale Hospital, Genoa

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D. Saverino Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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M. Raffa Endocrine-Metabolic Center, ASL 1, Imperia, Italy

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M. Caputo Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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F. Minuto Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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M. Giusti Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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M. Bagnasco Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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surgery and non-surgical approach for incidental papillary thyroid microcarcinoma. Eur J Endocrinol 2015;173:367-375. 10.1530/EJE-15-0454 26104754 13 Oda H, Miyauchi A, Ito Y, Yoshioka K, Nakayama A, Sasai H, Masuoka H, Yabuta T, Fukushima M

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Kanhaiyalal Agrawal Departments of Nuclear Medicine, London, UK

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James Weaver Departments of King's College London, London, UK

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Fahim Ul-Hassan Departments of Nuclear Medicine, London, UK
Departments of Clinical PET Centre, King's College London, London, UK

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Jean-Pierre Jeannon Departments of Otorhinolaryngology Head and Neck Surgery, London, UK

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Ricard Simo Departments of Otorhinolaryngology Head and Neck Surgery, London, UK

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Paul Carroll Departments of Consultant Endocrinologist, London, UK

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Johnathan G. Hubbard Departments of Consultant Endocrine Surgeon, Guy's and St Thomas' NHS Foundation Trust, London, UK

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Ashish Chandra Departments of Histopathology/Cytology, London, UK

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Hosahalli Krishnamurthy Mohan Departments of Nuclear Medicine, London, UK
Departments of Clinical PET Centre, King's College London, London, UK

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malignant tissue [ 2 ]. Incidental diffuse and focal thyroid uptake is often seen on 18 F-FDG PET/CT study. Diffuse uptake in the thyroid has been reported in approximately 0.6-3.3% of the 18 F-FDG PET studies and is often due to a benign aetiology [ 3

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Carles Zafon Department of Endocrinology, Spain
Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona and CIBERDEM (ISCIII), Barcelona, Spain

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Juan Antonio Baena Endocrine, Bariatric and Metabolic Unit, Department of General Surgery, Spain

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Josep Castellví Department of Pathology, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Spain

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Gabriel Obiols Department of Endocrinology, Spain
Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona and CIBERDEM (ISCIII), Barcelona, Spain

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Oscar Gonzalez Endocrine, Bariatric and Metabolic Unit, Department of General Surgery, Spain

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José Manuel Fort Endocrine, Bariatric and Metabolic Unit, Department of General Surgery, Spain

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Ramon Vilallonga Endocrine, Bariatric and Metabolic Unit, Department of General Surgery, Spain

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Enric Caubet Endocrine, Bariatric and Metabolic Unit, Department of General Surgery, Spain

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Manuel Armengol Endocrine, Bariatric and Metabolic Unit, Department of General Surgery, Spain

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Jordi Mesa Department of Endocrinology, Spain
Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona and CIBERDEM (ISCIII), Barcelona, Spain

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(incidental vs. non-incidental). We defined an incidental diagnosis as PTC diagnosed at final histology in a patient whose reason for intervention was benign thyroid disease. Quantitative variables were expressed as mean and standard deviation, and categorical

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Haggi Mazeh Department of Surgery, Jerusalem, Israel

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Amir Orlev Department of Surgery, Jerusalem, Israel

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Ido Mizrahi Department of Surgery, Jerusalem, Israel

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David J. Gross Endocrinology and Metabolism Service Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Herbert R. Freund Department of Surgery, Jerusalem, Israel

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much smaller in all cases and was not even sampled by fine-needle aspiration. Furthermore, in two cases, it was smaller than 5 mm. The rate of incidental MTC is not well established and the optimal treatment of such incidental findings is under debate

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Maria Rossing Department of Endocrinology, Herlev University Hospital, Herlev
Center of Genomic Medicine, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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Birte Nygaard Department of Endocrinology, Herlev University Hospital, Herlev

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Finn Cilius Nielsen Center of Genomic Medicine, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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Finn Noe Bennedbæk Department of Endocrinology, Herlev University Hospital, Herlev

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benign nodules and 50 cancers – 6 of the cancers were metastases from non-thyroid cancers (table 2 ). In addition, 37 patients with a benign index nodule were also diagnosed with an incidental PTMC. The prevalence of overall thyroid malignancies among

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Rachelle P Mendoza Department of Pathology, University of Rochester Medical Center, Rochester, New York, USA

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Richard Cody Simon Department of Pathology, University of Chicago, Chicago, Illinois, USA

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Nicole A Cipriani Department of Pathology, University of Chicago, Chicago, Illinois, USA

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Tatjana Antic Department of Pathology, University of Chicago, Chicago, Illinois, USA

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agreement between first and second FNA was significantly high ( 6 ). About 15% of their patients with benign first and second FNAs had a resection pathology of a thyroid malignancy, and 14% had incidental microcarcinoma, both rates were similar to benign

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