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-off (e.g. >2 ng/mL) should lead to selection for RAI. Whenever risk factors and patients’ selection for total thyroidectomy and radioiodine are evaluated, wide differences between countries as environmental factors, preclinical care and healthcare
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are convinced that at our institution, radioiodine remnant ablation (RRA), when administered after potentially curative bilateral thyroidectomy (BT) to low-risk (MACIS scores <6) adult PTC (APTC) patients, has not reduced ( 7 ) either cause
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-Tg) ≥10 ng/mL or rising thyroglobulin antibodies (TgAb) levels with negative imaging; InR were defined by LT4-Tg <1 ng/mL or rhTSH-Tg <10 ng/mL or stable/declining TgAb levels with non-specific findings on imaging or faint radioiodine uptake in thyroid bed
Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden
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Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden
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Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden
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increases the risk of GD approximately twofold and GO approximately threefold [ 6 ]. Independently of smoking, it has also been shown that higher TRAb increase the risk of GO both at and after diagnosis of GD [ 7 , 8 ]. Treatment of GD with radioiodine is
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Established Facts Orbital radioiodine uptake is highly uncommon, and some conditions associated with this finding are metastases as well as false-positive results due to contamination, inflammation, etc. Cystic structures located in
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tyrosine kinase inhibitors (TKIs). However, in up to 50% of cases, BMs have the absence of radioiodine uptake ( 11 ), and data on the effectiveness of TKIs are limited in this clinical entity ( 12 ). In parallel to these treatments, the role of
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, age, tumour size, histological subtypes, extrathyroidal spread, metastatic disease and iodine avidity [ 5 ]. Surgery, which includes total thyroidectomy and lymph node dissection followed by radioiodine ablation, remains the mainstay of treatment for
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, standardized treatment has consisted of a total thyroidectomy accompanied by a central or lateral neck lymph node dissection if indicated, followed by radioiodine ( 131 I) ablation, and thyroid hormone suppression therapy (THST) during follow-up. Although
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treatment ( 1 ). Two-thirds of metastatic DTCs lose their ability to uptake radioiodine (RAI) due to oncogene driver mutations silencing thyroid iodide-metabolizing genes, causing them to be RAI-resistant or refractory ( 1 , 2 , 3 ). Patients with RAI
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with postoperative radioiodine therapy (RAI) to ablate residual thyroid tissue and, in intermediate- to high-risk cases, to postoperatively (adjuvantly) treat occult foci of cancer in the surgical bed and elsewhere (for the purposes of this review, we