Chantal A Lebbink
Chantal A Lebbink
Wilhelmina Children’s Hospital and Princess Máxima Center, Utrecht, The Netherlands
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Thera P Links
Thera P Links
Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Agnieszka Czarniecka
Agnieszka Czarniecka
The Oncologic and Reconstructive Surgery Clinic, M. Sklodowska-Curie National Research Institute of Oncology Gliwice Branch, Gliwice, Poland
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Renuka P Dias
Renuka P Dias
Department of Paediatric Endocrinology and Diabetes, Birmingham Children's Hospital NHS Foundation Trust, Birmingham, United Kingdom
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Rossella Elisei
Rossella Elisei
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Louise Izatt
Louise Izatt
Department of Clinical Genetics, Guy's and St Thomas’ NHS Foundation Trust, London, United Kingdom
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Heiko Krude
Heiko Krude
Institute of Experimental Pediatric Endocrinology, Charité - Universitätsmedizin, Berlin, Germany
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Kerstin Lorenz
Kerstin Lorenz
Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
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Markus Luster
Markus Luster
Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany
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Kate Newbold
Kate Newbold
Thyroid Therapy Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom
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Arnoldo Piccardo
Arnoldo Piccardo
Department of Nuclear Medicine, EO Ospedali Galliera, Genoa, Italy
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Manuel Sobrinho-Simões
Manuel Sobrinho-Simões
University Hospital of São João, Medical Faculty and Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
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Toru Takano
Toru Takano
Thyroid Center, Rinku General Medical Center, Osaka, Japan
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A S Paul van Trotsenburg
A S Paul van Trotsenburg
Department of Pediatric Endocrinology, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
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Frederik A Verburg
Frederik A Verburg
Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
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Hanneke M van Santen
Hanneke M van Santen
Wilhelmina Children’s Hospital and Princess Máxima Center, Utrecht, The Netherlands
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from that in adults. In addition, the consequences of possible adverse effects of treatment may be different for children because of their longer life expectancy. These differences emphasize the need for specific recommendations for the pediatric
Stine Linding Andersen
Stine Linding Andersen
Departments of Endocrinology, Aalborg, Denmark
Departments of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
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Departments of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
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Peter Laurberg
Peter Laurberg
Departments of Endocrinology, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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iodine deficiency (ID) and the current recommendations on iodine supplementation in pregnant women, as well as the potential adverse consequences of inadequate or excessive iodine intake in pregnancy. Definition of ID in a Population and in
Stan R Ursem
Stan R Ursem
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
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Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
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Anita Boelen
Anita Boelen
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Eveline Bruinstroop
Eveline Bruinstroop
Department of Endocrinology and Metabolism, Amsterdam UMC, Location University of Amsterdam, Amsterdam, The Netherlands
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Petra J M Elders
Petra J M Elders
Department of General Practice, Amsterdam UMC Location Vrije Universiteit, Amsterdam, The Netherlands
Amsterdam Public Health Research Institute, Amsterdam UMC, The Netherlands
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Amsterdam Public Health Research Institute, Amsterdam UMC, The Netherlands
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Jacobijn Gussekloo
Jacobijn Gussekloo
LUMC Center for Medicine for Older People, Leiden University Medical Center, Leiden, The Netherlands
Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
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Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
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Rosalinde K E Poortvliet
Rosalinde K E Poortvliet
LUMC Center for Medicine for Older People, Leiden University Medical Center, Leiden, The Netherlands
Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
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Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
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Annemieke C Heijboer
Annemieke C Heijboer
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location Vrije Universiteit Amsterdam, Boelelaan, Amsterdam, The Netherlands
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Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location Vrije Universiteit Amsterdam, Boelelaan, Amsterdam, The Netherlands
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Wendy P J den Elzen
Wendy P J den Elzen
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Laboratory Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Public Health Research Institute, Meibergdreef, Amsterdam, The Netherlands
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Laboratory Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Public Health Research Institute, Meibergdreef, Amsterdam, The Netherlands
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, focusing on diagnostic workup, treatment, and follow-up. In addition, we investigated whether potential differences in recommendations could be explained by differences in (primary or secondary) healthcare systems and quality scores. Methods This
L.A. Jonker
L.A. Jonker
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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C.A. Lebbink
C.A. Lebbink
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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M.C.J. Jongmans
M.C.J. Jongmans
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
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R.A.J. Nievelstein
R.A.J. Nievelstein
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Pediatric Radiology and Nuclear Medicine, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Pediatric Radiology and Nuclear Medicine, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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J.H.M. Merks
J.H.M. Merks
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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E.J.M. Nieveen van Dijkum
E.J.M. Nieveen van Dijkum
Department of Surgery, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands
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T.P. Links
T.P. Links
Department of Endocrinology, University Medical Center Groningen, Groningen, The Netherlands
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N. Hoogerbrugge
N. Hoogerbrugge
Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands
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A.S.P. van Trotsenburg
A.S.P. van Trotsenburg
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Center, Amsterdam, The Netherlands
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H.M. van Santen
H.M. van Santen
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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thyroid surveillance recommendations for PHTS patients have been proposed [ 3 - 7 ]. The National Comprehensive Cancer Network (NCCN) in the USA recommends that pediatric PHTS patients receive an annual thyroid ultrasound from the age of diagnosis
Clare Yvonne England
Clare Yvonne England
National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, United Kingdom
Centre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, Bristol, United Kingdom
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Centre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, Bristol, United Kingdom
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Laura Moss
Laura Moss
Velindre Cancer Centre, Cardiff, United Kingdom
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Matthew Beasley
Matthew Beasley
University Hospitals Bristol NHS Trust, Bristol, United Kingdom
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Ingrid Haupt-Schott
Ingrid Haupt-Schott
Velindre Cancer Centre, Cardiff, United Kingdom
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Georgia Herbert
Georgia Herbert
National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, United Kingdom
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Charlotte Atkinson
Charlotte Atkinson
National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, United Kingdom
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Pacini F , Brianzoni E , Durante C , Elisei R , Ferdeghini M , Fugazzola L , et al. Recommendations for post-surgical thyroid ablation in differentiated thyroid cancer: a 2015 position statement of the Italian Society of Endocrinology . J
Maria Lopes-Pereira
Maria Lopes-Pereira
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
Hospital de Braga, Braga, Portugal
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ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
Hospital de Braga, Braga, Portugal
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Anna Quialheiro
Anna Quialheiro
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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Patrício Costa
Patrício Costa
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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Susana Roque
Susana Roque
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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Nadine Correia Santos
Nadine Correia Santos
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
ACMP5 – Associação Centro de Medicina P5 (P5), School of Medicine, University of Minho, Braga, Portugal
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ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
ACMP5 – Associação Centro de Medicina P5 (P5), School of Medicine, University of Minho, Braga, Portugal
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Margarida Correia-Neves
Margarida Correia-Neves
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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Ana Goios
Ana Goios
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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Ivone Carvalho
Ivone Carvalho
Newborn Screening, Metabolism & Genetics Unit, National Institute of Health Dr Ricardo Jorge, Porto, Portugal
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Tim I M Korevaar
Tim I M Korevaar
Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, the Netherlands
Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands
The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands
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Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands
The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands
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Laura Vilarinho
Laura Vilarinho
Newborn Screening, Metabolism & Genetics Unit, National Institute of Health Dr Ricardo Jorge, Porto, Portugal
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Joana Almeida Palha
Joana Almeida Palha
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
Clinical Academic Center-Braga (2CA-B), Braga, Portugal
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ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
Clinical Academic Center-Braga (2CA-B), Braga, Portugal
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maternal serum free thyroxine levels in the 1st trimester of pregnancy predicted infant psychomotor development, with altered behavior already detected at 12 months ( 14 ). These findings contributed to support a recommendation of the Portuguese National
Luca Persani
Luca Persani
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
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Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
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Georg Brabant
Georg Brabant
Experimental and Clinical Endocrinology Medical Clinic I – University of Lübeck, Lübeck, Germany
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Mehul Dattani
Mehul Dattani
Genetics and Genomic Medicine Programme, UCL GOS Institute of Child Health, London, United Kingdom
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Marco Bonomi
Marco Bonomi
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
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Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
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Ulla Feldt-Rasmussen
Ulla Feldt-Rasmussen
Department of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
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Eric Fliers
Eric Fliers
Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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Annette Gruters
Annette Gruters
Department for Pediatric Endocrinology and Diabetes, Charité University Medicine, Berlin, Germany
University Hospital Heidelberg, Heidelberg, Germany
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University Hospital Heidelberg, Heidelberg, Germany
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Dominique Maiter
Dominique Maiter
Department of Endocrinology and Nutrition, UCL Cliniques Saint-Luc, Brussels, Belgium
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Nadia Schoenmakers
Nadia Schoenmakers
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke’s Hospital and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, United Kingdom
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A.S. Paul van Trotsenburg
A.S. Paul van Trotsenburg
Department of Pediatric Endocrinology, Emma Children’s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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ETA task force. The members of the task force declare no conflict of interest and worked without any financial support. The draft guidance with the panel’s recommendations was released at the end of March 2018 and posted in the “members’ only” section
Ilaria Muller
Ilaria Muller
Thyroid Research Group, Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom
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Carla Moran
Carla Moran
Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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Beatriz Lecumberri
Beatriz Lecumberri
Department of Endocrinology and Nutrition, La Paz University Hospital, IdiPAZ, Autonomous University of Madrid, Madrid, Spain
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Brigitte Decallonne
Brigitte Decallonne
Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium
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Neil Robertson
Neil Robertson
Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom
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Joanne Jones
Joanne Jones
Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom
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Colin M. Dayan
Colin M. Dayan
Thyroid Research Group, Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom
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following search terms: IRT, secondary TA, alemtuzumab, HIV/HAART, BMT/HSCT, GD. The Grading of Recommendations Assessment, Development and Evaluation system was used to grade the quality of evidence and the strength of recommendations [ 48 , 49 ]. It
Laura Fugazzola
Laura Fugazzola
Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Rossella Elisei
Rossella Elisei
Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Dagmar Fuhrer
Dagmar Fuhrer
Department of Endocrinology, Diabetes and Metabolism, Endocrine Tumour Center at West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany
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Barbara Jarzab
Barbara Jarzab
Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Institute, Oncology Center, Gliwice Branch, Gliwice, Poland
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Sophie Leboulleux
Sophie Leboulleux
Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Université Paris Saclay, Villejuif, France
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Kate Newbold
Kate Newbold
Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, United Kingdom
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Jan Smit
Jan Smit
Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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life expectancy to 3–5 years once the disease is RAI-R [ 12 ]. Recommendation [R1] The development of dedifferentiation and RAI refractoriness during the course of the DTC should be taken into consideration. [R2] Poorly differentiated TC is
Luca Persani
Luca Persani
Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milano, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milano, Italy
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milano, Italy
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Patrice Rodien
Patrice Rodien
Service d’Endocrinologie-Diabétologie-Nutrition, Centre de référence des maladies rares de la Thyroïde et des récepteurs hormonaux, CHU d’Angers, Angers, France.
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Carla Moran
Carla Moran
Institute of Metabolic Science, University of Cambridge, Cambridge, UK
Endocrine Section, Beacon Hospital, Dublin, Ireland.
School of Medicine, University College Dublin, Ireland
Endocrinology Department, St Vincent’s University Hospital, Dublin, Ireland
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Endocrine Section, Beacon Hospital, Dublin, Ireland.
School of Medicine, University College Dublin, Ireland
Endocrinology Department, St Vincent’s University Hospital, Dublin, Ireland
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W Edward Visser
W Edward Visser
Department of Internal Medicine and Rotterdam Thyroid Center, Erasmus University Medical Center, Rotterdam, The Netherlands
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Stefan Groeneweg
Stefan Groeneweg
Department of Internal Medicine and Rotterdam Thyroid Center, Erasmus University Medical Center, Rotterdam, The Netherlands
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Robin Peeters
Robin Peeters
Department of Internal Medicine and Rotterdam Thyroid Center, Erasmus University Medical Center, Rotterdam, The Netherlands
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Samuel Refetoff
Samuel Refetoff
Departments of Medicine and Paediatrics and Committee on Genetics, The University of Chicago, Chicago, Illinois, USA
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Mark Gurnell
Mark Gurnell
Institute of Metabolic Science, University of Cambridge, Cambridge, UK
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Paolo Beck-Peccoz
Paolo Beck-Peccoz
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milano, Italy
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Krishna Chatterjee
Krishna Chatterjee
Institute of Metabolic Science, University of Cambridge, Cambridge, UK
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statements of key recommendations. This information was assessed by secondary reviewers, with dialogue between primary and secondary reviewers, amending the guidance. Finally, the guidance was further refined (and amended if necessary) by all members of the
