Pepijn van Houten
Pepijn van Houten
Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, the Netherlands
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James Nagarajah
James Nagarajah
Roentgeninstitut Duesseldorf, Duesseldorf, Germany
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Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
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Janneke E W Walraven
Janneke E W Walraven
Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands
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Martin Jaeger
Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, the Netherlands
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Adriana C H van Engen-van Grunsven
Adriana C H van Engen-van Grunsven
Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands
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Johannes W Smit
Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, the Netherlands
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Romana T Netea-Maier
Romana T Netea-Maier
Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, the Netherlands
Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
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Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
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and resistance to RAI-induced apoptosis ( 8 ). Strategies for restoring thyroid-specific gene expression by so-called ‘redifferentiation’, and thus NIS and TPO expression and function, followed by the administration of RAI, are promising treatment
Abdul Rehman Syed
Abdul Rehman Syed
University of Calgary, Calgary, Alberta, Canada
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Aakash Gorana
Aakash Gorana
Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Alberta, Canada
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Erik Nohr
Erik Nohr
Alberta Precision Laboratories, Molecular Pathology Program, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Xiaoli-Kat Yuan
Precision Oncology Hub Laboratory, Tom Baker Cancer Centre, Calgary, Alberta, Canada
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Parthiv Amin MASc
Parthiv Amin MASc
Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary Alberta, Canada
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Sana Ghaznavi
Sana Ghaznavi
Arnie Charbonneau Cancer Institute, Department of Medicine, Section of Endocrinology, University of Calgary, Calgary, Alberta, Canada
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Debbie Lamb
Debbie Lamb
Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Alberta, Canada
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John McIntyre
Precision Oncology Hub Laboratory, Tom Baker Cancer Centre, Calgary, Alberta, Canada
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Markus Eszlinger
Markus Eszlinger
Department of Oncology, Cumming School of Medicine, and Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada
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Ralf Paschke
Ralf Paschke
Departments of Medicine, Section of Endocrinology, Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Junyu Tong
Junyu Tong
Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China
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Maomei Ruan
Maomei Ruan
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
Department of Nuclear Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China
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Department of Nuclear Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China
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Yuchen Jin
Yuchen Jin
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Hao Fu
Hao Fu
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Lin Cheng
Lin Cheng
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Qiong Luo
Qiong Luo
Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China
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Zhiyan Liu
Zhiyan Liu
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Zhongwei Lv
Zhongwei Lv
Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China
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Libo Chen
Libo Chen
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Andries H Groen
Department of Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Deborah van Dijk
Deborah van Dijk
Department of Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Wim Sluiter
Wim Sluiter
Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Thera P Links
Thera P Links
Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Hendrik P Bijl
Hendrik P Bijl
Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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John T M Plukker
John T M Plukker
Department of Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Carles Zafon
Carles Zafon
Department of Endocrinology, Hospital Vall d'Hebron, and Diabetes and Metabolism Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona and CIBERDEM (ISCIII), Barcelona
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Juan J. Díez
Juan J. Díez
Department of Endocrinology and Nutrition, Hospital Ramón y Cajal
Department of Medicine, University of Alcalá de Henares, Madrid
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Department of Medicine, University of Alcalá de Henares, Madrid
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Juan C. Galofré
Juan C. Galofré
Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain
IdiSNA (Instituto de investigación en la salud de Navarra), Pamplona, Spain
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IdiSNA (Instituto de investigación en la salud de Navarra), Pamplona, Spain
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David S. Cooper
David S. Cooper
Division of Endocrinology, Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
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emerging therapeutic targets. Lancet Diabetes Endocrinol 2014;2:830-842. 52 Wong K-P, Lang BH-H: New molecular targeted therapy and redifferentiation therapy for radioiodine-refractory advanced papillary thyroid carcinoma: literature review. J
Andrew G Gianoukakis
Andrew G Gianoukakis
The Lundquist Institute at Harbor-UCLA Medical Center, David Geffen School of Medicine at UCLA, Torrance, California, USA
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Jennifer H Choe
Jennifer H Choe
Department of Medicine, Duke University Medical Center/Duke Cancer Institute, Durham, North Carolina, USA
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Daniel W Bowles
Daniel W Bowles
Division of Medical Oncology, University of Colorado, Aurora, Colorado, USA
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Marcia S Brose
Marcia S Brose
Department of Otorhinolaryngology: Head and Neck Surgery, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Lori J Wirth
Lori J Wirth
Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA
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Taofeek Owonikoko
Taofeek Owonikoko
Winship Cancer Institute of Emory University, Atlanta, Georgia, USA
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Svetlana Babajanyan
Svetlana Babajanyan
Bayer HealthCare Pharmaceuticals, Whippany, New Jersey, USA
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Francis P Worden
Francis P Worden
Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA
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Aashiq M Silverman DA Na’ara S Takahashi H & Amit M . Radioiodine-refractory thyroid cancer: molecular basis of redifferentiation therapies, management, and novel therapies . Cancers 2019 11 . ( https://doi.org/10.3390/cancers11091382 ) 9
Furio Pacini
Furio Pacini
Section of Endocrinology, University of Siena, Siena, Italy
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Dagmar Fuhrer
Dagmar Fuhrer
Department of Endocrinology, Diabetes and Metabolism, West German Cancer Centre (WTZ), University Hospital Essen, University Duisburg-Essen, Essen, Germany
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Rossella Elisei
Rossella Elisei
Section of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Daria Handkiewicz-Junak
Daria Handkiewicz-Junak
Department of Nuclear Medicine and Endocrine Oncology, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland
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Sophie Leboulleux
Sophie Leboulleux
Gustave Roussy Cancer Campus and University Paris-Saclay, Villejuif, Cedex, France
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Markus Luster
Markus Luster
Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany
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Martin Schlumberger
Martin Schlumberger
Gustave Roussy Cancer Campus and University Paris-Saclay, Villejuif, Cedex, France
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Johannes W Smit
Johannes W Smit
Radboud University Medical Center, Nijmegen, Netherlands
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with higher prevalence in these tumors than in classical PTC. As already mentioned, many tumors with aggressive histology, do not express NIS and do not have RAI uptake. This is the basis for redifferentiation protocols and such patients should be
Laura Fugazzola
Laura Fugazzola
Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Rossella Elisei
Rossella Elisei
Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Dagmar Fuhrer
Dagmar Fuhrer
Department of Endocrinology, Diabetes and Metabolism, Endocrine Tumour Center at West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany
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Barbara Jarzab
Barbara Jarzab
Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Institute, Oncology Center, Gliwice Branch, Gliwice, Poland
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Sophie Leboulleux
Sophie Leboulleux
Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Université Paris Saclay, Villejuif, France
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Kate Newbold
Kate Newbold
Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, United Kingdom
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Jan Smit
Jan Smit
Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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, dermatology, and cardiology. Several novel and promising perspectives are available for the treatment of advanced TC. Ongoing studies are evaluating the efficacy and safety of new MKIs, redifferentiation therapies, and of immunotherapeutic compounds to be
Chantal A Lebbink
Chantal A Lebbink
Wilhelmina Children’s Hospital and Princess Máxima Center, Utrecht, The Netherlands
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Thera P Links
Thera P Links
Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Agnieszka Czarniecka
Agnieszka Czarniecka
The Oncologic and Reconstructive Surgery Clinic, M. Sklodowska-Curie National Research Institute of Oncology Gliwice Branch, Gliwice, Poland
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Renuka P Dias
Renuka P Dias
Department of Paediatric Endocrinology and Diabetes, Birmingham Children's Hospital NHS Foundation Trust, Birmingham, United Kingdom
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Rossella Elisei
Rossella Elisei
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Louise Izatt
Louise Izatt
Department of Clinical Genetics, Guy's and St Thomas’ NHS Foundation Trust, London, United Kingdom
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Heiko Krude
Heiko Krude
Institute of Experimental Pediatric Endocrinology, Charité - Universitätsmedizin, Berlin, Germany
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Kerstin Lorenz
Kerstin Lorenz
Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
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Markus Luster
Markus Luster
Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany
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Kate Newbold
Kate Newbold
Thyroid Therapy Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom
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Arnoldo Piccardo
Arnoldo Piccardo
Department of Nuclear Medicine, EO Ospedali Galliera, Genoa, Italy
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Manuel Sobrinho-Simões
Manuel Sobrinho-Simões
University Hospital of São João, Medical Faculty and Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
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Toru Takano
Toru Takano
Thyroid Center, Rinku General Medical Center, Osaka, Japan
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A S Paul van Trotsenburg
A S Paul van Trotsenburg
Department of Pediatric Endocrinology, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
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Frederik A Verburg
Frederik A Verburg
Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
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Hanneke M van Santen
Hanneke M van Santen
Wilhelmina Children’s Hospital and Princess Máxima Center, Utrecht, The Netherlands
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461 – 470 ( https://doi.org/10.1089/thy.2018.0597 ) 122 Aashiq M Silverman DA Na’ara S Takahashi H Amit M . Radioiodine-refractory thyroid cancer: molecular basis of redifferentiation therapies, management, and novel therapies . Cancers
