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Tommaso Piticchio Endocrinology Section, Department of Clinical and Experimental Medicine, Garibaldi Nesima Hospital, University of Catania, Catania, Italy
Servizio di Endocrinologia e Diabetologia, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland

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Gilles Russ Department of Thyroid and Endocrine Tumor Diseases, La Pitie-Salpetriere Hospital, 83 Bd de l’Hopital, Paris, France

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Maija Radzina Riga Stradins University, Radiology Research Laboratory, Riga, Latvia
University of Latvia, Faculty of Medicine, Riga, Latvia

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Francesco Frasca Endocrinology Section, Department of Clinical and Experimental Medicine, Garibaldi Nesima Hospital, University of Catania, Catania, Italy

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Cosimo Durante Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

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Pierpaolo Trimboli Servizio di Endocrinologia e Diabetologia, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
Facoltà di Scienze Biomediche, Università della Svizzera Italiana (USI), Lugano, Switzerland

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). Considering the epidemiological figures and potential oncological implications, international guidelines recommend an immediate malignancy risk assessment for newly diagnosed TNs, and ultrasound (US) is universally recognized as the first-line diagnostic

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Berglind Jonsdottir Department of Clinical Sciences, Malmö, Lund University, Skåne University Hospital, Malmö, Sweden

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Markus Lundgren Department of Clinical Sciences, Malmö, Lund University, Skåne University Hospital, Malmö, Sweden

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Sara Wallengren Department of Clinical Sciences, Malmö, Lund University, Skåne University Hospital, Malmö, Sweden

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Åke Lernmark Department of Clinical Sciences, Malmö, Lund University, Skåne University Hospital, Malmö, Sweden

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Ida Jönsson Department of Clinical Sciences, Malmö, Lund University, Skåne University Hospital, Malmö, Sweden

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Helena Elding Larsson Department of Clinical Sciences, Malmö, Lund University, Skåne University Hospital, Malmö, Sweden

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(DiPiS) study. Methods Population The children in this cohort participate in the DiPiS study, a prospective population-based study in the southern part of Sweden, with the aim to determine the predictive value of genetic risk combined with

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Gilles Russ Thyroid and Endocrine Tumor Unit, Department of Nuclear Medicine, Pitié Salpêtrière Hospital, University Pierre et Marie Curie, Paris, France

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Sophie Leboulleux Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy, University Paris-Sud, Villejuif, France

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Laurence Leenhardt Thyroid and Endocrine Tumor Unit, Department of Nuclear Medicine, Pitié Salpêtrière Hospital, University Pierre et Marie Curie, Paris, France

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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managing a condition that the patient did not complain of. In the first part, this paper outlines the magnitude of the problem and updates the concept of US risk stratification of thyroid nodules based on the TIRADS (thyroid imaging reporting and data

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Aamna Hassan Department of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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Madeeha Khalid Department of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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Saima Riaz Department of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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M. Khalid Nawaz Department of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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Humayun Bashir Department of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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Introduction Although most patients with follicular thyroid carcinoma (FTC) have a favorable prognosis [ 1 ], metastatic and recurrent tumors continue to pose a challenge. It is important to correctly determine the risk of recurrence and to

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Juan J. Lence-Anta Institute of Oncology and Radiobiology, Havana, Cuba

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Constance Xhaard Radiation Epidemiology Group, 1018 INSERM Unit, Havana, Cuba
Institut Gustave Roussy, Havana, Cuba
University Paris-Sud, Villejuif, France

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Rosa M. Ortiz Institute of Oncology and Radiobiology, Havana, Cuba

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Haoiinda Kassim Radiation Epidemiology Group, 1018 INSERM Unit, Havana, Cuba
Institut Gustave Roussy, Havana, Cuba
University Paris-Sud, Villejuif, France

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Celia M. Pereda Institute of Oncology and Radiobiology, Havana, Cuba

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Silvia Turcios National Institute of Endocrinology, Havana, Cuba

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Milagros Velasco Institute of Oncology and Radiobiology, Havana, Cuba

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Mae Chappe Institute of Oncology and Radiobiology, Havana, Cuba

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Idalmis Infante Institute of Oncology and Radiobiology, Havana, Cuba

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Marlene Bustillo Institute of Oncology and Radiobiology, Havana, Cuba

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Anabel García Institute of Oncology and Radiobiology, Havana, Cuba

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Enora Clero Radiation Epidemiology Group, 1018 INSERM Unit, Havana, Cuba
Institut Gustave Roussy, Havana, Cuba
University Paris-Sud, Villejuif, France

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Stephane Maillard Radiation Epidemiology Group, 1018 INSERM Unit, Havana, Cuba
Institut Gustave Roussy, Havana, Cuba
University Paris-Sud, Villejuif, France

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Sirced Salazar Institute of Oncology and Radiobiology, Havana, Cuba

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Regla Rodriguez Cuban Health Public Ministry, Havana, Cuba

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Florent de Vathaire Radiation Epidemiology Group, 1018 INSERM Unit, Havana, Cuba
Institut Gustave Roussy, Havana, Cuba
University Paris-Sud, Villejuif, France

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Caledonia it reached 71.4/100,000 Melanesian women during 1985-1999 [ 10 ]. Until now, there are no clear explanations for these incidence variations. The only well-established risk factors of developing thyroid cancer are radiation exposure, a family

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Aamna Hassan Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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Saima Riaz Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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Humayun Bashir Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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M. Khalid Nawaz Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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Raza Hussain Departments of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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Introduction Differentiated thyroid cancer (DTC) is typically indolent if treated early and appropriately. A small subset of more aggressive disease progresses to radioiodine resistance. Based on the American Thyroid Association (ATA) risk of

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Constance Xhaard U1018, Centre d'Epidémiologie et de Santé des Populations (CESP), Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France
Institut Gustave Roussy, Villejuif, France
Université Paris-Saclay, Villejuif, France

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Juan J. Lence-Anta National Institute of Oncology and Radiobiology (INOR), Havana, Cuba

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Yan Ren U1018, Centre d'Epidémiologie et de Santé des Populations (CESP), Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France
Institut Gustave Roussy, Villejuif, France
Université Paris-Saclay, Villejuif, France

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Françoise Borson-Chazot Groupement Hospitalier Lyon-Est, Hospices Civils de Lyon, Fédération d'Endocrinologie, Bron
Rhône-Alpes Thyroid Cancer Registry, Cancer Research Center of Lyon (UMR INSERM 1052, CNRS 5286), RTH Laennec Faculty of Medicine, University of Lyon, Lyon

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Geneviève Sassolas Rhône-Alpes Thyroid Cancer Registry, Cancer Research Center of Lyon (UMR INSERM 1052, CNRS 5286), RTH Laennec Faculty of Medicine, University of Lyon, Lyon

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Claire Schvartz Thyroid Cancer Registry of Champagne-Ardennes, Institut Jean Godinot, Reims

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Marc Colonna Cancer Registry of Isère, Meylan

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Brigitte Lacour Institut Gustave Roussy, Villejuif, France
French National Registry of Childhood Solid Tumours, CHU, Nancy

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Arlette Danzon Cancer Registry of Doubs, EA 3181, Université de Franche-Comté, Besançon

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Michel Velten Cancer Registry of Bas-Rhin, EA 3430, Faculty of Medicine, University of Strasbourg, Strasbourg

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Enora Clero U1018, Centre d'Epidémiologie et de Santé des Populations (CESP), Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France
Institut Gustave Roussy, Villejuif, France
Université Paris-Saclay, Villejuif, France

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Stéphane Maillard U1018, Centre d'Epidémiologie et de Santé des Populations (CESP), Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France
Institut Gustave Roussy, Villejuif, France
Université Paris-Saclay, Villejuif, France

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Emilie Marrer Cancer Registry of Haut-Rhin, Mulhouse Hospital, Mulhouse

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Laurent Bailly Public Health Department, University Hospital Nice, Nice

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Eugènia Mariné Barjoan Public Health Department, University Hospital Nice, Nice

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Martin Schlumberger Institut Gustave Roussy, Villejuif, France

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Jacques Orgiazzi Department of Endocrinology, Hospices Civils de Lyon, Lyon, France

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Elisabeth Adjadj U1018, Centre d'Epidémiologie et de Santé des Populations (CESP), Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France
Université Paris-Saclay, Villejuif, France

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Celia M. Pereda National Institute of Oncology and Radiobiology (INOR), Havana, Cuba

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Silvia Turcios National Institute of Endocrinology, Cuba

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Milagros Velasco National Institute of Oncology and Radiobiology (INOR), Havana, Cuba

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Mae Chappe National Institute of Oncology and Radiobiology (INOR), Havana, Cuba

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Idalmis Infante National Institute of Oncology and Radiobiology (INOR), Havana, Cuba

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Marlene Bustillo National Institute of Oncology and Radiobiology (INOR), Havana, Cuba

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Anabel García National Institute of Oncology and Radiobiology (INOR), Havana, Cuba

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Sirced Salazar National Institute of Oncology and Radiobiology (INOR), Havana, Cuba

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Regla Rodriguez Cuban Public Health Ministry, Havana, Cuba

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Mohamed Amine Benadjaoud U1018, Centre d'Epidémiologie et de Santé des Populations (CESP), Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France
Institut Gustave Roussy, Villejuif, France
Université Paris-Saclay, Villejuif, France

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Rosa M. Ortiz National Institute of Oncology and Radiobiology (INOR), Havana, Cuba

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Carole Rubino U1018, Centre d'Epidémiologie et de Santé des Populations (CESP), Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France
Institut Gustave Roussy, Villejuif, France
Université Paris-Saclay, Villejuif, France

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Florent de Vathaire U1018, Centre d'Epidémiologie et de Santé des Populations (CESP), Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France
Institut Gustave Roussy, Villejuif, France
Université Paris-Saclay, Villejuif, France

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Introduction Over the last few decades, the differentiated thyroid cancer (DTC) incidence has grown rapidly in many countries [ 1 ]. The study of DTC risk factors is therefore of great importance to understand this observed increase in

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Samuel Chan Department of Ear, Nose, and Throat Surgery, St George’s Hospital, London, United Kingdom

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Katarina Karamali Department of Ear, Nose, and Throat Surgery, St George’s Hospital, London, United Kingdom

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Anna Kolodziejczyk Department of Ear, Nose, and Throat Surgery, St George’s Hospital, London, United Kingdom

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Georgios Oikonomou Department of Ear, Nose, and Throat Surgery, St George’s Hospital, London, United Kingdom

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John Watkinson Department of Ear, Nose, and Throat Surgery, GOSH, London, United Kingdom

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Vinidh Paleri The Royal Marsden Hospital, London, United Kingdom

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Iain Nixon Department of Ear, Nose, and Throat Surgery, NHS Lothian, University of Edinburgh, Edinburgh, United Kingdom

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Dae Kim Department of Ear, Nose, and Throat Surgery, St George’s Hospital, London, United Kingdom

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patients, which achieves excellent prognosis: 10-year overall survival of 98–99% and recurrence rates of 1–3% in low-risk DTC [ 3 ]. However, recognising their general indolent nature and excellent survival outcome, there have been calls for treatment de

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Bülent Öcal Department of Otolaryngology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

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Mehmet Hakan Korkmaz Department of Otolaryngology, Yıldırım Beyazıt University Medical School, Ankara, Turkey

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Demet Yılmazer Department of Pathology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

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Tuğba Taşkın Türkmenoğlu Department of Pathology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

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Ömer Bayır Department of Otolaryngology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

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Güleser Saylam Department of Otolaryngology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

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Emel Çadallı Tatar Department of Otolaryngology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

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Sevilay Karahan Department of Biostatistics, Faculty of Medicine, Hacettepe University, Ankara, Turkey

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Erman Çakal Department of Endocrinology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

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Introduction The estimated prevalence of thyroid nodules in an adult population is 4–7% by palpation and 10–41% by ultrasound (US) scanning [ 1 , 2 ]. The overall malignancy risk, regardless of nodule size, is < 10%, and even smaller nodules

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Laura P.B. Elbers Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam

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Hjalmar A. Boon Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam

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Maaike I. Moes Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam

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Bregje van Zaane Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam

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Dees P.M. Brandjes Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam

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Eric Fliers Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam

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Harry R. Büller Departments of Vascular Medicine, University of Amsterdam, Amsterdam

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Suzanne Cannegieter Department of Clinical Epidemiology, Leiden University Medical Center
Einthoven Laboratory for Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Victor E.A. Gerdes Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam

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Introduction Thyroid hormone affects metabolism in virtually every organ system. Several studies have indicated that thyroid hormone also influences the hemostatic balance and that these changes are associated with a risk of venous

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