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Eijun Nishihara Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Yoshitaka Hobo ASKA Pharmamedical Co., Ltd. Fujisawa, Japan

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Akira Miyauchi Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Yasuhiro Ito Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Miyoko Higuchi Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsuyoshi Hirokawa Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsuru Ito Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Shuji Fukata Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsushige Nishikawa Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Takashi Akamizu Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Introduction Thyroglobulin (Tg) is a thyroid-specific protein, and its serum levels are useful for monitoring patients with differentiated thyroid carcinomas (DTCs) who underwent total thyroidectomy. However, anti-Tg antibodies (TgAb) are

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Eftychia Koukkou Department of Endocrinology, E Venizelou Maternity Hospital, Athens

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Ioannis Ilias Department of Endocrinology, E Venizelou Maternity Hospital, Athens

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Irene Mamalis Departments of Endocrinology, Patras, Greece

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Georgios G. Adonakis Obstetrics and Gynecology, University of Patras Medical School, Patras, Greece

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Kostas B. Markou Departments of Endocrinology, Patras, Greece

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UIC is highly influenced by recent iodine intake, it can only be used to determine iodine status for populations and not for individuals [ 9 ]. Serum thyroglobulin (Tg) may also be a suitable marker of the current iodine status in a population

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Marta Amaro da Silveira Duval Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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André Borsatto Zanella Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Ana Patrícia Cristo Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Carlo Sasso Faccin Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Marcia Silva Graudenz Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Ana Luiza Maia Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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situation, with higher cutoffs suggested in non-thyroidectomized patients [ 16 ]. Moreover, one study suggests that positive serum anti-thyroglobulin antibodies (TgAb) lowered FNA-Tg levels and influenced the diagnostic accuracy of FNA-Tg in suspicious LNs

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Cláudia C.D. Nakabashi Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Fleury Medicina e Saúde, São Paulo, Brazil

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Teresa S. Kasamatsu Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo

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Felipe Crispim Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo

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Claudia A. Yamazaki Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo

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Cléber P. Camacho Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Danielle M. Andreoni Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Rosalia P. Padovani Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Elza S. Ikejiri Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Maria C.O.M. Mamone Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Flávia C. Aldighieri Fleury Medicina e Saúde, São Paulo, Brazil

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Jairo Wagner Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Jairo T. Hidal Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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José G.H. Vieira Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicina e Saúde, São Paulo, Brazil

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Rosa P.M. Biscolla Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Fleury Medicina e Saúde, São Paulo, Brazil

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Rui M.B. Maciel Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Fleury Medicina e Saúde, São Paulo, Brazil

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a nonsignificant risk of recurrence from undergoing unnecessary investigations and identify those individuals with a higher risk who merit closer follow-up [ 6 , 7 ]. The measurement of serum thyroglobulin (Tg) levels is one of the most important

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Till Ittermann Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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Adrian Richter Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
German Rheumatism Research Center, Berlin, Germany

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Martin Junge Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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Matthias Nauck Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany

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Astrid Petersmann Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
Institute for Clinical Chemistry, Interdisciplinary University Laboratory, University Medicine Göttingen, Göttingen, Germany

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Clemens Jürgens Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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Harald Below Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Greifswald, Germany

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Carsten Oliver Schmidt Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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Henry Völzke Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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agreement over the twelve visits, with mean differences of 0.09 mIU/L and 0.21 pmol/L and SDs of 0.06 mIU/L and 0.14 pmol/L, respectively. Very good agreements across the visits were observed for serum thyroglobulin level and thyroid volume. For the

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Birte Nygaard Departments of Endocrinology, Herlev Hospital, Copenhagen

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Jens Bentzen Departments of Oncology, Herlev Hospital, Copenhagen

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Peter Laurberg Department of Endocrinology, Aalborg Hospital, Aalborg

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Susanne Møller Pedersen Departments of Biochemistry, Odense University Hospital, Odense

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Lars Bastholt Departments of Oncology, Odense University Hospital, Odense

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Aase Handberg Departments of Biochemistry, Aarhus Hospital, Aarhus, Denmark

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Carsten Rytter Departments of Oncology, Aarhus Hospital, Aarhus, Denmark

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Christian Godballe ENT Head and Neck Surgery, Odense University Hospital, Odense

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Jens Faber Departments of Endocrinology, Herlev Hospital, Copenhagen

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]. International guidelines [ 4 , 5 ] suggest a differentiation of patients into low and high risk, low risk patients having a life expectancy close to that of the background population. Serum thyroglobulin (s-Tg) is used as a tumor marker during follow-up after

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Hao Li Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Otorhinolaryngology, Tan Tock Seng Hospital, Singapore, Singapore

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Nir Livneh Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Otolaryngology, Head and Neck Surgery, Sheba Medical Center, Ramat Gan, Israel

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Snjezana Dogan Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Ashok R. Shaha Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Endocrinol . 2010 ; 72 ( 4 ): 534 – 42 . http://dx.doi.org/10.1111/j.1365-2265.2009.03666.x . 25 Miyauchi A , Kudo T , Miya A , Kobayashi K , Ito Y , Takamura Y , . Prognostic impact of serum thyroglobulin doubling-time under

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Emilio Fiore Department of Experimental and Clinical Medicine, Endocrinology Unit 1, University Hospital of Pisa, Pisa, Italy

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Francesco Latrofa Department of Experimental and Clinical Medicine, Endocrinology Unit 1, University Hospital of Pisa, Pisa, Italy

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Paolo Vitti Department of Experimental and Clinical Medicine, Endocrinology Unit 1, University Hospital of Pisa, Pisa, Italy

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L, Basolo F, Ugolini C, Pinchera A, Vitti P: Lymphocytic thyroiditis on histology correlates with serum thyroglobulin autoantibodies in patients with papillary thyroid carcinoma: impact on detection of serum thyroglobulin. J Clin Endocrinol Metab

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Chitra Choudhary Department of Endocrinology, Medstar Washington Hospital Center, Washington, D.C., USA

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Leonard Wartofsky Department of Endocrinology, Medstar Washington Hospital Center, Washington, D.C., USA

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Eshetu Tefera MedStar Health Research Institute, Washington, D.C., USA

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Kenneth D. Burman Department of Endocrinology, Medstar Washington Hospital Center, Washington, D.C., USA

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Introduction Differentiated thyroid cancer patients are monitored for local or distant recurrence after total thyroidectomy. They typically undergo physical examination, serial measurement of serum thyroglobulin (Tg) levels, and serial

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Giovanna Rotondo Dottore Department of Clinical and Experimental Medicine, Endocrinology Unit II, University of Pisa and University Hospital of Pisa, Pisa, Italy

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Marenza Leo Department of Clinical and Experimental Medicine, Endocrinology Unit II, University of Pisa and University Hospital of Pisa, Pisa, Italy

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Roberta Ricciardi Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa and University Hospital of Pisa, Pisa, Italy
Department of Surgical, Medical and Molecular Pathology, Division of Thoracic Surgery, University of Pisa and University Hospital of Pisa, Pisa, Italy

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Michelangelo Maestri Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa and University Hospital of Pisa, Pisa, Italy

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Ilaria Bucci Department of Clinical and Experimental Medicine, Endocrinology Unit II, University of Pisa and University Hospital of Pisa, Pisa, Italy

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Marco Lucchi Department of Surgical, Medical and Molecular Pathology, Division of Thoracic Surgery, University of Pisa and University Hospital of Pisa, Pisa, Italy

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Franca Melfi Department of Surgical, Medical and Molecular Pathology, Division of Thoracic Surgery, University of Pisa and University Hospital of Pisa, Pisa, Italy

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Melania Guida Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa and University Hospital of Pisa, Pisa, Italy

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Anna De Rosa Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa and University Hospital of Pisa, Pisa, Italy

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Loredana Petrucci Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa and University Hospital of Pisa, Pisa, Italy

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Ilaria Ionni Department of Clinical and Experimental Medicine, Endocrinology Unit II, University of Pisa and University Hospital of Pisa, Pisa, Italy

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Giulia Lanzolla Department of Clinical and Experimental Medicine, Endocrinology Unit II, University of Pisa and University Hospital of Pisa, Pisa, Italy

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Francesca Nicolì Department of Clinical and Experimental Medicine, Endocrinology Unit II, University of Pisa and University Hospital of Pisa, Pisa, Italy

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Michele Mantuano Department of Clinical and Experimental Medicine, Endocrinology Unit II, University of Pisa and University Hospital of Pisa, Pisa, Italy

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Debora Ricci Department of Clinical and Experimental Medicine, Endocrinology Unit II, University of Pisa and University Hospital of Pisa, Pisa, Italy

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Francesco Latrofa Department of Clinical and Experimental Medicine, Endocrinology Unit II, University of Pisa and University Hospital of Pisa, Pisa, Italy

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Stefano Mariotti Department of Medical Sciences and Public Health, University of Cagliari, Monserrato, Italy

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Claudio Marcocci Department of Clinical and Experimental Medicine, Endocrinology Unit II, University of Pisa and University Hospital of Pisa, Pisa, Italy

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Michele Marinò Department of Clinical and Experimental Medicine, Endocrinology Unit II, University of Pisa and University Hospital of Pisa, Pisa, Italy

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behaviour of serum anti-thyroglobulin autoantibodies (TgAbs) and anti-thyroperoxidase autoantibodies (TPOAbs) in relation to thymectomy over a 48-week follow-up period, with visits at 24 and 48 weeks. The secondary outcome was the relationship between TgAbs

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