Kirsten E. Stewart
Kirsten E. Stewart
Department of Head and Neck Surgery, St John’s Hospital at Howden, Livingston, United Kingdom
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Mark W.J. Strachan
Mark W.J. Strachan
Metabolic Unit, Western General Hospital, Edinburgh, United Kingdom
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Devraj Srinivasan
Devraj Srinivasan
Department of Oncology, Western General Hospital, Edinburgh, United Kingdom
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Morna MacNeill
Morna MacNeill
Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
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Lucy Wall
Lucy Wall
Department of Oncology, Western General Hospital, Edinburgh, United Kingdom
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Iain J. Nixon
Iain J. Nixon
Department of Head and Neck Surgery, St John’s Hospital at Howden, Livingston, United Kingdom
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). What Does This Case Report Add? This case illustrates a patient with locally advanced DTC treated with tyrosine kinase inhibitor (TKI) therapy, which markedly reduced tumour volume and allowed subsequent successful surgical resection without
Min Ren
Min Ren
Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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Qianlan Yao
Qianlan Yao
Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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Longlong Bao
Longlong Bao
Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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Zhiting Wang
Zhiting Wang
Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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Ran Wei
Ran Wei
Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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Qianming Bai
Qianming Bai
Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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Bo Ping
Bo Ping
Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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Cai Chang
Cai Chang
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
Department of Ultrasound, Fudan University Shanghai Cancer Center, Shanghai, China
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Department of Ultrasound, Fudan University Shanghai Cancer Center, Shanghai, China
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Yu Wang
Yu Wang
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
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Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
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Xiaoyan Zhou
Xiaoyan Zhou
Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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Xiaoli Zhu
Xiaoli Zhu
Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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populations, and ThyroSeq NGS assays are not available for Chinese patients. In the current study, we used a multigene NGS panel to detect targeted DNA mutations and RNA fusions in a large cohort of 1041 samples including FNA materials and surgical resections
Zhen Gao
Zhen Gao
The First Department of Oncology, Hebei General Hospital, Shijiazhuang, China
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Hongtao Zhang
Hongtao Zhang
The First Department of Oncology, Hebei General Hospital, Shijiazhuang, China
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Lijuan Zhang
Lijuan Zhang
The First Department of Oncology, Hebei General Hospital, Shijiazhuang, China
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Huimin Yu
Huimin Yu
The First Department of Oncology, Hebei General Hospital, Shijiazhuang, China
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Xuemin Di
Xuemin Di
The First Department of Oncology, Hebei General Hospital, Shijiazhuang, China
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Zeyang Wang
Zeyang Wang
The First Department of Oncology, Hebei General Hospital, Shijiazhuang, China
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Zezhou Liu
Zezhou Liu
The First Department of Oncology, Hebei General Hospital, Shijiazhuang, China
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Aixia Sui
Aixia Sui
The First Department of Oncology, Hebei General Hospital, Shijiazhuang, China
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Juan Wang
Juan Wang
The First Department of Oncology, Hebei General Hospital, Shijiazhuang, China
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Gaofeng Shi
Gaofeng Shi
Department of Radiology, The 4th Affiliated Hospital of Hebei Medical University, Shijiazhuang, China
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Established Facts The incidence of thyroid cancer has increased in almost every part of the world. Papillary thyroid carcinoma (PTC) is typically treated with surgical resection, even in recurrent cases. However, it is difficult to
Brigitte Decallonne
Brigitte Decallonne
Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium
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Annick Van den Bruel
Annick Van den Bruel
Department of Endocrinology, General Hospital St Jan, Bruges, Belgium
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Gilles Macq
Gilles Macq
Department of Research, Belgian Cancer Registry, Brussels, Belgium
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Nathalie Elaut
Nathalie Elaut
Department of Research, Belgian Cancer Registry, Brussels, Belgium
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Harlinde De Schutter
Harlinde De Schutter
Department of Research, Belgian Cancer Registry, Brussels, Belgium
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thyroid resection specimens in the HIR as compared to the LIR. To our knowledge, the link between thyroid cancer incidence, surgical rates, and the weight of the surgical specimens has not been studied yet. In the current study, we aimed to examine
Inês Damásio
Inês Damásio
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Joana Simões-Pereira
Joana Simões-Pereira
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Sara Donato
Sara Donato
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Nova Medical School, Lisbon, Portugal
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Nova Medical School, Lisbon, Portugal
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Mariana Horta
Mariana Horta
Radiology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon Portugal
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Branca Maria Cavaco
Branca Maria Cavaco
Molecular Pathobiology Research Unit (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Miguel Rito
Miguel Rito
Pathology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Pedro Gomes
Pedro Gomes
Head and Neck Surgery Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Valeriano Leite
Valeriano Leite
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Nova Medical School, Lisbon, Portugal
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Nova Medical School, Lisbon, Portugal
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all thyroid malignancies. Despite its rarity, ATC is one of the most aggressive solid tumors in humans, with a median survival of 5–6 months ( 1 ). Historically, the standard treatment for ATC includes surgical resection, if feasible, followed by
Irini S. Hadjisavva
Irini S. Hadjisavva
Economides Nicosia Endocrinology Center, Nicosia, Cyprus
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Roberto Dina
Roberto Dina
Department of Cellular Pathology, Hammersmith Hospital, Imperial College Healthcare Trust, London, UK
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Michael A. Talias
Michael A. Talias
Healthcare Management Postgraduate Program, Open University of Cyprus, Nicosia, Cyprus
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Panayiotis A. Economides
Panayiotis A. Economides
Economides Nicosia Endocrinology Center, Nicosia, Cyprus
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malignant [ 3 , 5 , 6 , 7 ]. It is a simple, safe and most accurate method for selecting the patients who will need surgical resection or follow-up. Ultrasound-guided FNA (USgFNA) has improved diagnostic accuracy compared to FNA by palpation [ 8 , 9
Benjamin Chevalier
Benjamin Chevalier
Department of Endocrinology, Diabetology and Metabolism, Lille University Hospital, Lille, France
University of Lille, Lille, France
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University of Lille, Lille, France
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Oriane Karleskind
Oriane Karleskind
Department of Pathology, Lille University Hospital, Lille, France
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Arnaud Jannin
Arnaud Jannin
Department of Endocrinology, Diabetology and Metabolism, Lille University Hospital, Lille, France
University of Lille, Lille, France
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University of Lille, Lille, France
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Olivier Farchi
Olivier Farchi
Department of Biochemistry and Molecular Biology, Hormonology Metabolism Nutrition Oncology, Lille University Hospital, Lille, France
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Catherine Vermaut
Catherine Vermaut
Department of Biochemistry and Molecular Biology, Hormonology Metabolism Nutrition Oncology, Lille University Hospital, Lille, France
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Alexandre Escande
Alexandre Escande
Academic Department of Radiation Oncology, Oscar Lambret Comprehensive Cancer Center, Lille, France
CRIStAL UMR CNRS 9189, University of Lille, Villeneuve-d’Ascq, France
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CRIStAL UMR CNRS 9189, University of Lille, Villeneuve-d’Ascq, France
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Clio Baillet
Clio Baillet
Department of Nuclear Medicine, Lille University Hospital, Lille, France
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Stéphanie Espiard
Stéphanie Espiard
Department of Endocrinology, Diabetology and Metabolism, Lille University Hospital, Lille, France
University of Lille, Lille, France
Institut National de la Santé et de la Recherche Médicale (INSERM), European Genomic Institute for Diabetes (EGID), CHU Lille, Lille, France
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University of Lille, Lille, France
Institut National de la Santé et de la Recherche Médicale (INSERM), European Genomic Institute for Diabetes (EGID), CHU Lille, Lille, France
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Marie-Christine Vantyghem
Marie-Christine Vantyghem
Department of Endocrinology, Diabetology and Metabolism, Lille University Hospital, Lille, France
University of Lille, Lille, France
Institut National de la Santé et de la Recherche Médicale (INSERM), European Genomic Institute for Diabetes (EGID), CHU Lille, Lille, France
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University of Lille, Lille, France
Institut National de la Santé et de la Recherche Médicale (INSERM), European Genomic Institute for Diabetes (EGID), CHU Lille, Lille, France
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Bruno Carnaille
Bruno Carnaille
University of Lille, Lille, France
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Emmanuelle Leteurtre
Emmanuelle Leteurtre
University of Lille, Lille, France
Department of Pathology, Lille University Hospital, Lille, France
University of Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, Lille, France
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Department of Pathology, Lille University Hospital, Lille, France
University of Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, Lille, France
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Christine Do Cao
Christine Do Cao
Department of Endocrinology, Diabetology and Metabolism, Lille University Hospital, Lille, France
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ATC patients with complete remission, mostly after multimodal treatment effective in downsizing the tumor for surgical resection. However, we chose to not include them in our table because of the absence of complete pathological response on
Jihwan Yoo
Jihwan Yoo
Department of Neurosurgery, Brain Tumor Center, Gangnam Severance Hospital, Seoul, Republic of Korea
College of Medicine, Yonsei University, Seoul, Republic of Korea
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College of Medicine, Yonsei University, Seoul, Republic of Korea
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Hee Jun Kim
Hee Jun Kim
Department of Surgery, CHA Ilsan Medical Center, Cha University School of Medicine, Goyang-si, Republic of Korea
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Seok Mo Kim
Seok Mo Kim
Department of Surgery, Thyroid Cancer Center, Gangnam Severance Hospital, Institute of Refractory Thyroid Cancer, Yonsei University College of Medicine, Seoul, Republic of Korea
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Hun Ho Park
Hun Ho Park
Department of Neurosurgery, Brain Tumor Center, Gangnam Severance Hospital, Seoul, Republic of Korea
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carcinoma types ( 1 ). However, 0.15–1.3% of patients with thyroid cancer develop brain metastasis with a median survival time of 4–33 months ( 2 , 3 , 4 , 5 , 6 ). The treatment options for such patients include surgical resection, stereotactic
Rachelle P Mendoza
Rachelle P Mendoza
Department of Pathology, University of Rochester Medical Center, Rochester, New York, USA
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Richard Cody Simon
Richard Cody Simon
Department of Pathology, University of Chicago, Chicago, Illinois, USA
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Nicole A Cipriani
Nicole A Cipriani
Department of Pathology, University of Chicago, Chicago, Illinois, USA
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Tatjana Antic
Tatjana Antic
Department of Pathology, University of Chicago, Chicago, Illinois, USA
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thyroid nodules. Clinical practices have ranged from ultrasound monitoring to repeat FNA. Flanagan et al. studied 70 patients with two or more repeat FNA after an initial benign result and then subsequently underwent surgical management ( 5 ). The repeat
Mahdi Kamoun
Mahdi Kamoun
Endocrinology and Metabolism Department
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Michèle d'Herbomez
Michèle d'Herbomez
Department of Nuclear Medicine, Lille University Hospital, Lille
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Christine Lemaire
Christine Lemaire
Department of Endocrinology, Regional Hospital of Béthune, Béthune
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Armelle Fayard
Armelle Fayard
Endocrinology and Metabolism Department
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Rachel Desailloud
Rachel Desailloud
Endocrinology and Metabolism Department, Amiens University Hospital, Amiens, France
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Damien Huglo
Damien Huglo
Department of Nuclear Medicine, Lille University Hospital, Lille
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Jean-Louis Wemeau
Jean-Louis Wemeau
Endocrinology and Metabolism Department
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fluctuated between 4.4 and 18.8 µU/ml; FT3 between 6.6 and 8.6 pmol/l, and FT4 between 11 and 35.5 pmol/l. Wishing a quick and speedy recovery, the patient desired surgical intervention. She underwent total right lobectomy with partial left lobectomy after
