Laura Tosatto
Laura Tosatto
Human Technopole, Milano, Italy
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Francesca Coscia
Francesca Coscia
Human Technopole, Milano, Italy
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Introduction: thyroglobulin in thyroid hormone homeostasis The two thyroid hormones (TH) 3,5,3',5'-tetraiodo- l -thyronine (T4) and 3,3′,5-triiodo- l -thyronine (T3) are crucial for human metabolism and development ( 1 , 2 ). T4 is produced
Bernadette L Dekker
Bernadette L Dekker
Internal Medicine, Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Anouk N A van der Horst-Schrivers
Anouk N A van der Horst-Schrivers
Internal Medicine, Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
Department of Emergency Medicine, Maastricht University Medical Center, Maastricht, the Netherlands
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Department of Emergency Medicine, Maastricht University Medical Center, Maastricht, the Netherlands
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Adrienne H Brouwers
Adrienne H Brouwers
Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Christopher M Shuford
Christopher M Shuford
Laboratory Corporation of America Holdings, Center for Esoteric Testing, Burlington, North California, USA
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Ido P Kema
Ido P Kema
Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Anneke C Muller Kobold
Anneke C Muller Kobold
Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Thera P Links
Thera P Links
Internal Medicine, Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Introduction In the follow-up of patients with differentiated thyroid carcinoma (DTC), thyroglobulin (Tg) is a well-recognized tumor marker, and therefore, highly accurate Tg measurements are crucial ( 1 ). However, current immunoassays can
Shaodong Hou
Shaodong Hou
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, China
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Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, China
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Yiceng Sun
Yiceng Sun
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
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Zeyu Yang
Zeyu Yang
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
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Mi Tang
Mi Tang
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
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Tingjie Yin
Tingjie Yin
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
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Cong Shao
Cong Shao
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
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Cunye Yan
Cunye Yan
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
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Linlong Mo
Linlong Mo
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
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Yuquan Yuan
Yuquan Yuan
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
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Supeng Yin
Supeng Yin
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
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Fan Zhang
Fan Zhang
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, China
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Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, China
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frozen sections is relatively high, this approach still has some drawbacks, such as the requirement of some advanced equipment and experienced pathologists. Thyroglobulin (Tg) is a macromolecular tetrameric glycoprotein with a molecular weight of 600
Nianting Ju
Nianting Ju
Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Liying Hou
Liying Hou
Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Hongjun Song
Hongjun Song
Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Zhongling Qiu
Zhongling Qiu
Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Yang Wang
Yang Wang
Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Zhenkui Sun
Zhenkui Sun
Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Quanyong Luo
Quanyong Luo
Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Chentian Shen
Chentian Shen
Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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considered to be a significant treatment for eliminating the remnant thyroid tissue after thyroidectomy, which can increase the specificity of detectable serum thyroglobulin (Tg) as a tumor marker and potentially improve the quality of future 131 I whole
Carla Gambale
Carla Gambale
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy
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Alessandro Prete
Alessandro Prete
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy
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Lea Contartese
Lea Contartese
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy
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Liborio Torregrossa
Liborio Torregrossa
Department of Surgical, Medical, Molecular Pathology and Critical Area, Anatomic Pathology Section, University Hospital of Pisa, Pisa, Italy
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Francesca Bianchi
Francesca Bianchi
Department of Nuclear Medicine, University Hospital of Pisa, Pisa, Italy
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Eleonora Molinaro
Eleonora Molinaro
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy
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Gabriele Materazzi
Gabriele Materazzi
Department of Surgical, Medical, Molecular Pathology and Critical Area, Unit of Endocrine Surgery, University Hospital of Pisa, Pisa, Italy
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Rossella Elisei
Rossella Elisei
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy
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Antonio Matrone
Antonio Matrone
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy
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pathologic factors, including the ATA class of risk. BiR/InR were defined according to ATA 2015 guidelines as follows: BiR in case of thyroglobulin value on levothyroxine therapy (LT4-Tg) ≥1 ng/mL or Tg peak after recombinant human TSH stimulation (rhTSH
Marta Amaro da Silveira Duval
Marta Amaro da Silveira Duval
Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
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André Borsatto Zanella
André Borsatto Zanella
Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
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Ana Patrícia Cristo
Ana Patrícia Cristo
Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
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Carlo Sasso Faccin
Carlo Sasso Faccin
Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
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Marcia Silva Graudenz
Marcia Silva Graudenz
Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
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Ana Luiza Maia
Ana Luiza Maia
Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
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cellularity or unsatisfying sampling precludes diagnosis in up to 20% of specimens, depending on the cytopathologist’s experience and skill [ 9 , 10 ]. Measurement of thyroglobulin in the washout of fine needle aspiration (FNA-Tg) has been used as an
Eijun Nishihara
Eijun Nishihara
Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
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Nobuyuki Amino
Nobuyuki Amino
Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
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Takumi Kudo
Takumi Kudo
Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
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Kazuyoshi Kohsaka
Kazuyoshi Kohsaka
Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
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Mitsuru Ito
Mitsuru Ito
Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
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Shuji Fukata
Shuji Fukata
Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
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Mitsushige Nishikawa
Mitsushige Nishikawa
Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
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Hirotoshi Nakamura
Hirotoshi Nakamura
Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
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Akira Miyauchi
Akira Miyauchi
Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
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, and positivity for thyroglobulin (Tg) hemagglutination antibodies and microsomal antibodies was tested [ 8 ]. However, the method was not sensitive enough to detect low levels of anti-thyroid antibodies. Therefore, earlier negative reports using Tg and
Mathieu Spaas
Mathieu Spaas
Department of Radiation Oncology, KU Leuven – University of Leuven, University Hospitals Leuven, Leuven, Belgium
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Brigitte Decallonne
Brigitte Decallonne
Department of Endocrinology and Internal Medicine, KU Leuven – University of Leuven, University Hospitals Leuven, Leuven, Belgium
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Annouschka Laenen
Annouschka Laenen
Leuven Biostatistics and Statistical Bioinformatics Centre, Leuven, Belgium
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Jaak Billen
Jaak Billen
Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium
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Sandra Nuyts
Sandra Nuyts
Department of Radiation Oncology, KU Leuven – University of Leuven, University Hospitals Leuven, Leuven, Belgium
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normal thyroid tissue; secondly, RRA allows for serum thyroglobulin (Tg) to be used as a specific tumor marker and increases sensitivity of diagnostic whole-body iodine scintigraphy (WBS) in the follow-up, allowing early detection of recurrent or
Stefan Matei Constantinescu
Stefan Matei Constantinescu
Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium
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Julien Hospel
Julien Hospel
Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium
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Chantal Daumerie
Chantal Daumerie
Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium
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Orsalia Alexopoulou
Orsalia Alexopoulou
Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium
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Dominique Maiter
Dominique Maiter
Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium
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Maria-Cristina Burlacu
Maria-Cristina Burlacu
Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium
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-stimulating antibodies (TRAb) that are responsible for the major manifestations of hyperthyroidism, i.e. goiter and orbitopathy ( 2 ). Other thyroid antibodies, namely, thyroperoxidase (TPOAb) and thyroglobulin (TgAb) antibodies, are also frequently elevated in GD, but
Yuan Li
Yuan Li
Department of Endocrinology, Peking University First Hospital, Beijing, China
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Chenxu Zhao
Chenxu Zhao
Department of Endocrinology, Peking University First Hospital, Beijing, China
Department of Endocrinology, The First Hospital of Hebei Medical University, Shijiazhuang, China
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Department of Endocrinology, The First Hospital of Hebei Medical University, Shijiazhuang, China
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Keli Zhao
Keli Zhao
Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
College of Life Science, University of the Chinese Academy of Sciences, Beijing, China
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College of Life Science, University of the Chinese Academy of Sciences, Beijing, China
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Nan Yu
Nan Yu
Department of Endocrinology, Peking University First Hospital, Beijing, China
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Yan Li
Yan Li
Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
College of Life Science, University of the Chinese Academy of Sciences, Beijing, China
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College of Life Science, University of the Chinese Academy of Sciences, Beijing, China
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Yang Yu
Yang Yu
Department of Endocrinology, Peking University First Hospital, Beijing, China
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Yang Zhang
Yang Zhang
Department of Endocrinology, Peking University First Hospital, Beijing, China
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Zhijing Song
Zhijing Song
Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
College of Life Science, University of the Chinese Academy of Sciences, Beijing, China
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College of Life Science, University of the Chinese Academy of Sciences, Beijing, China
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Youyuan Huang
Youyuan Huang
Department of Endocrinology, Peking University First Hospital, Beijing, China
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Guizhi Lu
Guizhi Lu
Department of Endocrinology, Peking University First Hospital, Beijing, China
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Ying Gao
Ying Gao
Department of Endocrinology, Peking University First Hospital, Beijing, China
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Junqing Zhang
Junqing Zhang
Department of Endocrinology, Peking University First Hospital, Beijing, China
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Xiaohui Guo
Xiaohui Guo
Department of Endocrinology, Peking University First Hospital, Beijing, China
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Introduction Thyroglobulin antibodies (TgAb), frequently found in healthy individuals, are serological markers of both Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) [ 1 ]. In papillary thyroid carcinoma (PTC), the rate of TgAb
