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Linda M. Thienpont Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Gent

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Katleen Van Uytfanghe Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Gent

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Sofie Van Houcke Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Gent

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Barnali Das Biochemistry and Immunology Laboratory, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, India

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James D. Faix Stanford University School of Medicine, Palo Alto, Calif., Abbott Park, Ill., USA

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Finlay MacKenzie Birmingham Quality/UK NEQAS, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Frank A. Quinn Medical and Scientific Affairs, Abbott Diagnostics, Abbott Laboratories, Abbott Park, Ill., USA

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Michael Rottmann Roche Diagnostics GmbH, Penzberg, Germany

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Annick Van den Bruel Department of Endocrinology, General Hospital Sint Jan, Bruges, Belgium

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laboratory tests include lipids, HbA1c, creatinine, and enzymes [ 4 , 5 , 6 , 7 ], but more are under development [ 8 , 9 , 10 , 11 ]. The IFCC Committee for Standardization of Thyroid Function Tests (C-STFT) aims at equivalence of laboratory testing for

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Federica D’Aurizio Department of Laboratory Medicine, Institute of Clinical Pathology, University Hospital of Udine, Udine, Italy

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Alessia Biasotto Department of Medicine, University of Udine, Udine, Italy

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Claudia Cipri Endocrinology, Metabolism and Clinical Nutrition Unit, University Hospital of Udine, Udine, Italy

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Franco Grimaldi Endocrinology, Metabolism and Clinical Nutrition Unit, University Hospital of Udine, Udine, Italy

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Jessica Zucco Department of Laboratory Medicine, Institute of Clinical Pathology, University Hospital of Udine, Udine, Italy

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Stefania Marzinotto Department of Laboratory Medicine, Institute of Clinical Pathology, University Hospital of Udine, Udine, Italy

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Francesco Curcio Department of Laboratory Medicine, Institute of Clinical Pathology, University Hospital of Udine, Udine, Italy
Department of Medicine, University of Udine, Udine, Italy

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Salvatore Benvenga Department of Clinical and Experimental Medicine, Endocrinology Section, University of Messina, Messina, Italy

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Established facts Thyroid function tests (TFT) are the most commonly requested endocrine tests in both inpatient and outpatient settings. Constant interaction among the clinician, the laboratory and the manufacturer is of paramount

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Rajesh Rajput Department of Endocrinology and Medicine Unit V, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Rohtak, India

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Vaibhav Pathak Department of Endocrinology and Medicine Unit V, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Rohtak, India

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switched to weekly LT4 therapy it increased to 3.9 ± 1.1 mIU/L ( p ≤ 0.001) (Table 2 ). Table 1. Baseline characteristics of study groups I and II Table 2. Intragroup comparison of thyroid function test of group I and group II at

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Stine Linding Andersen Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

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Stig Andersen Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

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this focused review, we discuss the continuum of maternal thyroid function test abnormalities in pregnancy. Specifically, we describe the assessment of maternal thyroid function in pregnancy, the management of overt and subclinical thyroid disease, and

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Inge Bülow Pedersen Department of Endocrinology and Medicine, Aalborg University Hospital, Aalborg, Denmark

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Peter Laurberg Department of Endocrinology and Medicine, Aalborg University Hospital, Aalborg, Denmark

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sporadic Graves' disease and genomic activating mutations in the TSH receptor of the neonate [ 1 ]. Despite the clinical thyrotoxicosis of the patient, thyroid function tests are important tools in diagnosing hyperthyroidism. The results of the tests are

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Zohar Steinberg Ben-Zeev Pediatric Department A, Ha’Emek Medical Center, Afula, Israel

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Marina Peniakov Neonatal Intensive Care Unit, Ha’Emek Medical Center, Afula, Israel

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Clari Felszer Neonatal Intensive Care Unit, Ha’Emek Medical Center, Afula, Israel

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Scott A Weiner Neonatal Intensive Care Unit, Ha’Emek Medical Center, Afula, Israel

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Avishay Lahad Pediatric Department A, Ha’Emek Medical Center, Afula, Israel

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Shlomo Almashanu The National Newborn Screening Program, Ministry of Health, Tel Hashomer, Ramat Gan, Israel

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Yardena Tenenbaum Rakover Consulting Medicine in Pediatric Endocrinology, Clalit Health Services, Afula, Israel
The Rappaport Faculty of Medicine, Technion, Institute of Technology, Haifa, Israel

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primary congenital hypothyroidism (CH) ( 17 , 18 ). The potential effects of maternal thyroid disease on offspring have led to the clinical practice of recommending serum thyroid function tests (TFT), including free T4 (FT4) and TSH, in infants born to

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Torquil Watt Department of Endocrinology, Copenhagen University Hospital Rigshospitalet
Institute of Public Health, University of Copenhagen

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Jakob Bue Bjorner Institute of Public Health, University of Copenhagen
National Research Centre for the Working Environment, Copenhagen

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Mogens Groenvold Institute of Public Health, University of Copenhagen
Department of Palliative Medicine, Bispebjerg Hospital

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Steen Joop Bonnema Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Åse Krogh Rasmussen Department of Endocrinology, Copenhagen University Hospital Rigshospitalet

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Ulla Feldt-Rasmussen Department of Endocrinology, Copenhagen University Hospital Rigshospitalet

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and cubed values. To test the stability of the results, several post hoc analyses were performed. In the univariate pairwise analyses of the relationship between QoL scales and thyroid function, the latter was also operationalized as (a) current

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Theodora Pappa Endocrine Unit, Department of Clinical Therapeutics, Alexandra Hospital

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Maria Alevizaki Endocrine Unit, Department of Clinical Therapeutics, Alexandra Hospital
Department of Endocrinology, Metabolism and Diabetes, Evgenideion Hospital, Athens University School of Medicine, Athens, Greece

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alternative. Furthermore, the increased prevalence of hypothyroidism in patients with DM is another factor illustrating the clinical relevance of metformin's effect on thyroid function tests [ 6 ]. In addition, various reports have linked metformin use with

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Peter Laurberg Department of Endocrinology, Aalborg Hospital, Aalborg

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Nils Knudsen Medical Clinic I, Bispebjerg Hospital, Copenhagen, Denmark

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Stig Andersen Department of Endocrinology, Aalborg Hospital, Aalborg

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Allan Carlé Department of Endocrinology, Aalborg Hospital, Aalborg

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Inge Bülow Pedersen Department of Endocrinology, Aalborg Hospital, Aalborg

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Jesper Karmisholt Department of Endocrinology, Aalborg Hospital, Aalborg

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axis leading to changes in thyroid function tests overlapping with the abnormalities seen in primary thyroid disease. A special area of practical concern is the common complaint from patients treated for thyroid disease that therapy has led to

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Mahdi Kamoun Endocrinology and Metabolism Department

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Michèle d'Herbomez Department of Nuclear Medicine, Lille University Hospital, Lille

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Christine Lemaire Department of Endocrinology, Regional Hospital of Béthune, Béthune

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Armelle Fayard Endocrinology and Metabolism Department

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Rachel Desailloud Endocrinology and Metabolism Department, Amiens University Hospital, Amiens, France

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Damien Huglo Department of Nuclear Medicine, Lille University Hospital, Lille

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Jean-Louis Wemeau Endocrinology and Metabolism Department

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thyrotoxicosis recurred 2 months later, and the patient was referred to our university department. Thyroid function tests after immuno-precipitation were as follow: FT3 10.3 pmol/l; FT4 48.3 pmol/l, and TSH 5.4 µU/ml. Serum concentration of the α-TSH was elevated

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