European Thyroid Association Guidelines on L-T4 + L-T3 Combination for Hypothyroidism: A Weary Step in the Right Direction

in European Thyroid Journal
Author:
Petros Perros Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK

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*Dr. Petros Perros, Department of Endocrinology, Elliott Building, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP (UK), Tel. +44 191 282 0590, E-Mail petros.perros@ncl.ac.uk
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  • 1

    Wiersinga WM, Duntas L, Fadeyev V, Nygaard B, Vanderpump MPJ: 2012 ETA Guidelines: the use of L-T4 + L-T3 in the treatment of hypothyroidism. Eur Thyroid J 2012;1:55–71.

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  • 2

    Bunevicius R, Kazanavicius G, Zalinkevicius R, Prange AJ Jr: Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism. N Engl J Med 1999;340:424–429.

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    • Export Citation
  • 3

    Saravanan P, Chau WF, Roberts N, Vedhara K, Greenwood R, Dayan CM: Psychological well-being in patients on ‘adequate’ doses of L-thyroxine: results of a large, controlled community-based questionnaire study. Clin Endocrinol (Oxf) 2002;57:577–585.

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  • 4

    Clyde PW, Harari AE, Getka EJ, Shakir KM: Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: a randomized controlled trial. JAMA 2003;290:2952–2958.

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  • 5

    Sawka AM, Gerstein HC, Marriott MJ, MacQueen GM, Joffe RT: Does a combination regimen of thyroxine (T4) and 3, 5, 3′-triiodothyronine improve depressive symptoms better than T4 alone in patients with hypothyroidism? Results of a double-blind, randomized, controlled trial. J Clin Endocrinol Metab 2003;88:4551–4555.

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    • Export Citation
  • 6

    Walsh JP, Shiels L, Lim EM, Bhagat CI, Ward LC, Stuckey BG, Dhaliwal SS, Chew GT, Bhagat MC, Cussons AJ: Combined thyroxine/liothyronine treatment does not improve well-being, quality of life, or cognitive function compared to thyroxine alone: a randomized controlled trial in patients with primary hypothyroidism. J Clin Endocrinol Metab 2003;88:4543–4550.

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  • 7

    Wiersinga WM: Do we need still more trials on T4 and T3 combination therapy in hypothyroidism? Eur J Endocrinol 2009;161:955–959.

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  • 8

    Ladenson PW: Psychological wellbeing in patients with hypothyroidism. Clin Endocrinol (Oxf) 2002;57:575–576.

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    • Export Citation
  • 9

    Mitchell AL, Hickey B, Hickey JL, Pearce SH: Trends in thyroid hormone prescribing and consumption in the UK. BMC Public Health 2009;9:132–211.

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    • Export Citation
  • 10

    Hannemann A, Friedrich N, Haring R, Krebs A, Völzke H, Alte D, Nauck M, Kohlmann T, Schober H-C, Hoffmann W, Wallaschofski H: Thyroid function tests in patients taking thyroid medication in Germany: results from the population-based Study of Health in Pomerania (SHIP). BMC Res Notes 2010;3:227–231.

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    • Export Citation
  • 11

    Baskin HJ, Cobin RH, Duick DS, Gharib H, Guttler RB, Kaplan MM, Segal RL, American Association of Clinical Endocrinologists: American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism. Endocr Pract 2002;8:457–469.

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    • Export Citation
  • 12

    Muller AF, Berghout A, Wiersinga WM, Kooy A, Smits JW, Hermus AR, working group Thyroid Function Disorders of the Netherlands Association of Internal Medicine: Thyroid function disorders – Guidelines of the Netherlands Association of Internal Medicine. Neth J Med 2008;66:134–142.

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    • Export Citation
  • 13

    Royal College of Physicians: The Diagnosis and Management of Primary Hypothyroidism. http://www.british-thyroid-association. org/news/Docs/hypothyroidism_statement.pdf.

    • PubMed
    • Export Citation
  • 14

    Razvi S, Weaver JU, Pearce SH: Subclinical thyroid disorders: significance and clinical impact. J Clin Pathol 2010;63:379–386.

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    • Export Citation
  • 15

    Duntas LH, Biondi B: New insights into subclinical hypothyroidism and cardiovascular risk. Semin Thromb Hemost 2011;37:27–34.

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