Association of maternal thyroid peroxidase antibody exposure with children’s emotional and behavioral problems

in European Thyroid Journal
Authors:
Penggui Wu P Wu, Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, NHC Key Laboratory of study on abnormal gametes and reproductive tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, China

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Mengting Yang M Yang, Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, NHC Key Laboratory of study on abnormal gametes and reproductive tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, China

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Yuzhu Teng Y Teng, Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, NHC Key Laboratory of study on abnormal gametes and reproductive tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, China

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Jiajun Ouyang J Ouyang, Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, NHC Key Laboratory of study on abnormal gametes and reproductive tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, China

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Wenjin Cai W Cai, Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, NHC Key Laboratory of study on abnormal gametes and reproductive tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, China

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Juan Tong J Tong, Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, NHC Key Laboratory of study on abnormal gametes and reproductive tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, China

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Guopeng Gao G Gao, Maternal and Child Health Center in Ma, ma'anshan, China

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Xiaoyan Wu X Wu, Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, NHC Key Laboratory of study on abnormal gametes and reproductive tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, China

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Yan Han Y Han, Xuzhou Medical University, Xuzhou, China

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Shuangqin Yan S Yan, Maternal and Child Health Center in Ma, ma'anshan, China

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Fangbiao Tao F Tao, Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, NHC Key Laboratory of study on abnormal gametes and reproductive tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, China

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Kun Huang K Huang, Department of Maternal, Child and Adolescent Health, Anhui Medical University, Hefei, China

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Correspondence: Kun Huang, Email: ahmuhuangk@163.com
DOI:
https://doi.org/10.1530/ETJ-24-0302
Volume/Issue:
Accepted Manuscripts
Article Type:
Research Article
Article ID:
ETJ-24-0302
Online Publication Date:
01 Apr 2025
Copyright:
© 2025 The authors 2025
Open access

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Abstract

Objective: Maternal thyroid peroxidase antibody (TPOAb) positivity has been associated with a variety of pregnancy complications and has potential neuropsychological developmental implications for the offspring. The aim of our study was to explore the effect of maternal TPOAb levels on emotional and behavioural problems in children.

Design: Cohort study

Participants: Based on the Maanshan Birth Cohort in China, 2464 mother-infant pairs were included in this study.

Measurements: Repeated blood samples were collected from pregnant women and TPOAb and FT4 were measured retrospectively by electrochemiluminescence immunoassay (ECLIA). The Strengths and Difficulties Questionnaire (SDQ) was used to assess the emotional and behavioural problems of 4-year-old preschoolers.

Results: After adjusting for potential confounders, maternal TPOAb positivity during the third trimester of pregnancy was found to be associated with an elevated risk of conduct problems in girls, with an OR of 2.190 (95% CI: 1.137 - 4.219). Conversely, maternal TPOAb positivity in the first trimester was linked to a decreased incidence of prosocial behavior in boys, with an OR of 0.451 (95% CI: 0.237 - 0.861).

Conclusions: Maternal TPOAb positivity during pregnancy may be associated with emotional and behavioral problems in preschool - aged children.

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Online ISSN:
2235-0802
Copyright:
© 2025 The authors 2025
Article ID:
ETJ-24-0302
Article Type:
Research Article
Received Date:
27 Sep 2024
Rev-recd:
25 Feb 2025
Accepted Date:
08 Apr 2025
Print Publication Date:
Apr 2025
Online Publication Date:
01 Apr 2025